Superfund Research Program Publications

Reflections from the Well is the e-newsletter of the UNC Superfund Research Program. It is issued quarterly and features significant program accomplishments and highlights the work of several projects and cores in each issue. The newsletter is distributed to elected officials, environmental and community-based organizations, various governmental contacts, other SRPs, etc.

Volume 9

Study finds humanized female mice “protected” metabolically from arsenic exposure
Geologic mapping of ancient volcanic rock could better predict arsenic in NC wells
Trainee Highlight: Jenna Todero
Trainee reflects on KC Donnelly Externship
Collaborating on NC well water issues
UNC SRP CEC leads discussions at 2024 PEPH Meeting
NIEHS Grantee Highlight: Andrew George, Ph.D. – Forging Partnerships to Reach and Empower Rural Well Water Users
NCWELL Data Working Group shares insights to address well contamination
Dr. Coronell brings PFAS solutions to science teachers
UNC SRP shares findings at Annual Meeting and SOT
Middle school scientists learn the value of clean water

Volume 8

Volume 7

IDEA Learners program brings teachers and researchers together
SRP trainee brings focus to environmental injustice in NC
From The Well: Students played key role in testing for lead on campus
NIEHS Extramural Paper of the Month: An interaction of inorganic arsenic exposure with body weight and composition on type 2 diabetes indicators in Diversity Outbred mice

Volume 6

Volume 5

Volume 4

Volume 3

Volume 2

Volume 1

Peer-reviewed Publications

2024

Alvarado, TR; Austin, RE; Bradley, PJ; Eaves, LA; Fry, RC; George, A; Gray, KM; Osborne, JA; Stýblo, M; Vinson, DS; Duckworth, OW. (2024) Geologic Predictors of Drinking Water Well Contamination in North Carolina. PLOS Water, 3: e0000194. DOI: 10.1371/journal.pwat.0000194.

Cheng X, An J, Lou J, Gu Q, Ding W, Droby G, Wang Y, Wang C, Gao Y, Shelton A, Satterlee AB, Mann BE, Hsiao YC, Liu CW, Liu K, Hingtgen S, Wang J, Liu Z, Miller R, Wu D, Vaziri C, Yang Y. Trans-Lesion Synthesis and Mismatch Repair Pathway Crosstalk Defines Chemoresistance and Hypermutation Mechanisms in Glioblastoma. Nat Commun 15, 1957 (2024). DOI: 10.1038/s41467-024-45979-5. PubMed PMID: 37886584; PubMed Central PMCID: PMC10602147.

Obeidy, CS; Polizzotto, ML. (2024) Understanding the influence of soil development on contaminant reactivity along a fluvial chronosequence in the Oregon Coast Range. Geoderma, Volume 442, 2024, 116784. DOI: 10.1016/j.geoderma.2024.116784.

Wilson, L; Hayes, WJ; Jones, CN; Eaves, L; Wait, K; George, A; Freeman, B; Mize, W; Fowlkes, J; Currie, J; Burchell, M; Gray, K; Fry, R; Pieper, KJ. (2024) Lead occurrence in North Carolina well water: Importance of sampling representation and collection techniques. Environmental Research Letters. DOI: 10.1088/1748-9326/ad2b2c.

2023

Balogun, F; Aiken, M; Namayandeh, A; Duckworth, OW; Polizzotto, ML. (2023) Dissolved organic carbon diminishes manganese oxide-driven oxidation of chromium. Chemosphere, 344, 140424. DOI: 10.1016/j.chemosphere.2023.140424.

Carberry, CK; Bangma, J; Koval, L; Keshava, D; Hartwell, HJ; Sokolsky, M; Fry, RC; Rager, JE. (2023) Extracellular Vesicles altered by a Per- and Polyfluoroalkyl Substance Mixture: In Vitro Dose-Dependent Release, Chemical Content, and MicroRNA Signatures involved in Liver Health. Toxicol Sci. DOI: 10.1093/toxsci/kfad108. PMID: 37851381.

Douillet C.; Miller M.; Cable P.H.; Shi Q.; El‐Masri H.; Matoušek T.; Koller B.H.; Thomas D.J.; Stýblo M. (2023) Fate of arsenicals in mice carrying the human AS3MT gene exposed to environmentally relevant levels of arsenite in drinking water. Scientific Reports 2023, 13, 3360. DOI: 10.1038/s41598-023-30723-8.

Eaves, L.A.; Choi, G.; Hall, E.; Sille, F.C.M.; Fry, R.C; Buckley, J.P.; Keil, A.P. (2023). Prenatal Exposure to Toxic Metals and Neural Tube Defects: A Systematic Review of the Epidemiologic Evidence. Environmental Health Perspectives, 131(8). DOI: 10.1289/EHP11872.

Eaves, L.A.; Fry, R.C. (2023). Invited Perspective: Toxic Metals and Hypertensive Disorders of Pregnancy. Environmental Health Perspectives, 131(4). DOI: doi.org/10.1289/EHP11963.

Eaves, L.A.; Keil, A.P.; Jukic, A.M.; Dhingra, R.; Brooks, J.L.; Manuck, T.A.; Rager, J.E.; Fry, R.C. (2023) Toxic metal mixtures in private well water and increased risk for preterm birth in North Carolina. Environmental Health, 22(1), 69. DOI: 10.1186/s12940-023-01021-7.

Eaves, L.A.; Lanier P.; Enggasser A.E.; Chung G.; Turla T.; Rager J.E., Fry R.C. (2023) Generation of the Chemical and Social Stressors Integration Technique (CASS-IT) to identify areas of holistic public health concern: An application to North Carolina. Science of The Total Environment 2023, 862, 409. DOI: 10.1016/j.scitotenv.2022.160409.

Fashe M.M., Miner T.A., Fallon J.K., Schauer A.P., Sykes C., Smith P.C., Lee C.R. Pregnancy related hormones increase CYP3A mediated buprenorphine metabolism in human hepatocytes: a comparison to CYP3A substrates nifedipine and midazolam. Front Pharmacol. 2023;14:1218703. DOI: 10.3389/fphar.2023.1218703. eCollection 2023. PubMed PMID: 37475714; PubMed Central PMCID: PMC10354249.

Freedman, A.N.; Clark, J.; Eaves, L.A.; Roell, K.; Oran, A.; Koval, L.; Rager, J.; Santos, H.P. Jr.; Kuban, K.; Joseph, R.M.; Frazier, J.; Marsit, C.J.; Burt, A.A.; O’Shea, T.M.; Fry, R.C. (2023). A multi-omic approach identifies an autism spectrum disorder (ASD) regulatory complex of functional epimutations in placentas from children born preterm. Autism Res, 16(5):918-934. DOI: 10.1002/aur.2915. PMID: 36938998; PMCID: PMC10192070.

George, A.; Gray, K.; Wait, K.; Gallagher, D.; Edwards, M.; Currie, J.; Hogan, J.; Kwasikpui, A.W.; Pieper, K.J. (2023) Drinking Water Disparities in North Carolina Communities Served by Private Wells. Environmental Justice, DOI: 10.1089/env.2022.0100

Gray, K.M.; Blanchard, M.R.; LePrevost, C.E. | Li, F. (reviewing editor). (2023) Educator beliefs and organizational constraints: Factors that influence informal education about fish consumption advisories in a southeastern US state. Sustainable Environment, 9(1). DOI: 10.1080/27658511.2023.2259716

Hsiao YC, Matulewicz RS, Sherman SE, Jaspers I, Weitzman ML, Gordon T, Liu CW, Yang Y, Lu K, Bjurlin MA. (2023). Untargeted Metabolomics to Characterize the Urinary Chemical Landscape of E-Cigarette Users. Chem Res Toxicol. 2023 Apr 17;36(4):630-642. DOI: 10.1021/acs.chemrestox.2c00346. PubMed PMID: 36912507; PubMed Central PMCID: PMC10371198.

Ji M, Xu X, Xu Q, Hsiao YC, Martin C, Ukraintseva S, Popov V, Arbeev KG, Randall TA, Wu X, Garcia-Peterson LM, Liu J, Xu X, Andrea Azcarate-Peril M, Wan Y, Yashin AI, Anantharaman K, Lu K, Li JL, Shats I, Li X. (2023). Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota. Nat Metab. 2023 Sep;5(9):1526-1543. DOI: 10.1038/s42255-023-00854-3. PubMed PMID: 37537369; PubMed Central PMCID: PMC10513933.

Medina, S.; Zhang, H.; Santos-Medina, L.V.; Yee, Z.A.; Martin, K.J.; Wan, G.; Bolt, A.M.; Zhou, X.; Stýblo, M.; Liu, K.J. (2023). Arsenite Methyltransferase Is an Important Mediator of Hematotoxicity Induced by Arsenic in Drinking Water. Water 2023, 15, 448. DOI: 10.3390/w15030448

Perry, LA; Chew, NGP; Grzebyk, K; Cay-Durgun, P; Lind, ML; Sitaula, P; Soukri, M; Coronell, O. (2023). Correlating the Role of Nanofillers with Active Layer Properties and Performance of Thin-Film Nanocomposite Membranes. Desalination, 550. DOI: 10.1016/j.desal.2023.116370. PMID: 37274380; PMCID: PMC10237506.

Shang, B; Venkatratnam, A; Liu, T; Douillet, C; Shi, Q; Miller, M; Cable, P; Zou, F; Ideraabdullah, FY; Fry, RC; Stýblo, M.(2023). Sex-specific transgenerational effects of preconception exposure to arsenite: metabolic phenotypes of C57BL/6 offspring. Arch Toxicol, 97(11):2879-2892. DOI: 10.1007/s00204-023-03582-5. PMID: 37615676; PMCID: PMC10754030.

Soares, MB; Duckworth, OW; Stýblo, M; Cable, PH; Alleoni, LRF. (2023). Pyrolysis temperature and biochar redox activity on arsenic availability and speciation in a sediment. J Hazard Mater. DOI: 10.1016/j.jhazmat.2023.132308. PMID: 37639794; PMCID: PMC10528781.

Todero, J; Douillet, C; Shumway, AJ; Koller, BH; Kanke, M; Phuong, DJ; Stýblo, M; Sethupathy, P. (2023) Molecular and Metabolic Analysis of Arsenic-Exposed Humanized AS3MT Mice. Environmental Health Perspectives, 131(12), 127021. DOI: 10.1289/EHP12785.

Yan F, Liu Y, Cai J, Zhou H. (2023). Estimated quadratic inference function for correlated failure time data. Biometrics. 2023 Jun;79(2):1145-1158. DOI: 10.1111/biom.13633. Epub 2022 Mar 9. PubMed PMID: 35146750; PubMed Central PMCID: PMC9365883.

Yang, Y; Chi, L; Liu, CW; Hsiao, YC; Lu, K. (2023). Chronic Arsenic Exposure Perturbs Gut Microbiota and Bile Acid Homeostasis in Mice. Chem Res Toxicol, 36(7):1037-1043. DOI: 10.1021/acs.chemrestox.2c00410. PMID: 37295807; PMCID: PMC10773974.

Yang, Y; Hsiao, YC; Liu, CW; Lu, K. (2023). The Role of the Nuclear Receptor FXR in Arsenic-Induced Glucose Intolerance in Mice. Toxics. DOI: 10.3390/toxics11100833. PMID: 37888683; PMCID: PMC10611046.

Yelton, S.; George, A.; Tomlinson, M.S.; Bommarito, P.A.; Fry, R.C.; Gray, K.M. (2023). Communicating results of drinking water tests from private wells: Designing report-back materials to facilitate understanding. Journal of Environmental Health, 85(8), 8-14.

Zhang W, Chew NGP, Coronell O. (2023). Facile Synthesis of Electrically Conductive Membranes. Environ Sci Technol Lett, 10(11):1135-1141. DOI: 10.1021/acs.estlett.3c00631. PMID: 38144434; PMCID: PMC10735243.

2022

Alowaifeer, AM; Clingenpeel, S; Kan, J; Bigelow, PE; Yoshinaga, M; Bothner, B; McDermott, TR. (2022). Arsenic and Mercury Distribution in an Aquatic Food Chain: Importance of Femtoplankton and Picoplankton Filtration Fractions. Environ Toxicol Chem., 42(1):225-241. DOI: 10.1002/etc.5516. PMID: 36349954; PMCID: PMC10753857.

Armstrong, M.D.; Vickers, R.; Coronell, O. (2022). Trends and errors in reverse osmosis membrane performance calculations stemming from test pressure and simplifying assumptions about concentration polarization and solute rejection. Journal of Membrane Science, 660, 120856. DOI: 10.1016/j.memsci.2022.120856

Armstrong, M.D.; Vickers, R.; Coronell, O. (2022). Dataset of reverse osmosis membrane transport properties calculated with and without assumptions about concentration polarization and solute rejection and the errors associated with each assumption. Data in Brief, 44, 108538. DOI: 10.1016/j.dib.2022.108538

Avery C. L., Howard A. G., Ballou A. F., Buchanan V. L., Collins J. M., Downie C. G., Engel S. M., Graff M., Highland H. M., Lee M. P., Lilly A. G., Lu K., Rager J. E., Staley B. S., North K. E., Gordon-Larsen P. (2022). Strengthening Causal Inference in Exposomics Research: Application of Genetic Data and Methods. Environ Health Perspect. DOI: 10.1289/EHP9098.

Carberry, C.K.; Rager, J.E. (2022). The impact of environmental contaminants on extracellular vesicles and their key molecular regulators: A literature and database-driven review. Environmental and Molecular Mutagenesis 2022. 64, 2522. DOI: 10.1002/em.22522

Carberry C.K., Keshava D., Payton A., Smith G.J., Rager J.E. (2022). Approaches to incorporate extracellular vesicles into exposure science, toxicology, and public health research. J Expo Sci Environ Epidemiol. 2022 Sep;32(5):647-659. DOI: 10.1038/s41370-022-00417-w. PubMed PMID: 35217808; PubMed Central PMCID: PMC9402811.

Carberry C.K., Ferguson S.S., Beltran A.S., Fry R.C., Rager J.E. (2022). Using liver models generated from human induced pluripotent stem cells (iPSCs) for evaluating chemical-induced modifications and disease across liver developmental stages. Toxicol In Vitro. 2022 Sep;83:105412. DOI: 10.1016/j.tiv.2022.105412. PubMed PMID: 35688329; PubMed Central PMCID: PMC9296547.

Carberry C.K., Koval L.E., Payton A., Hartwell H., Ho Kim Y., Smith G.J., Reif D.M., Jaspers I., Ian Gilmour M., Rager J.E. (2022). Wildfires and extracellular vesicles: Exosomal MicroRNAs as mediators of cross-tissue cardiopulmonary responses to biomass smoke. Environ Int. 2022 Sep;167:107419. DOI: 10.1016/j.envint.2022.107419. PubMed PMID: 35863239; PubMed Central PMCID: PMC9389917.

Duckworth, OW; Polizzotto, ML; Thompson, A. Bringing soil chemistry to environmental health science to tackle soil contaminants. (2022). Front Environ Sci. DOI: 10.3389/fenvs.2022.981607. PMID: 36407845; PMCID: PMC9673486.

Eaves, LA; Bulka, CM; Rager, JE; Gardner, AJ; Galusha, AL; Parsons, PJ; O’Shea, TM; Fry, RC. (2022). Metal mixtures modeling identifies birth weight-associated gene networks in the placentas of children born extremely preterm. Chemosphere, 313:137469. DOI: 10.1016/j.chemosphere.2022.137469. PMID: 36493891; PMCID: PMC10476282.

Eaves, L. A., Keil, A. P., Rager, J. E., George, A., & Fry, R. C. (2022). Analysis of the novel NCWELL database highlights two decades of co-occurrence of toxic metals in North Carolina private well water: Public health and environmental justice implications. Science of The Total Environment, 151479.

Fraser, A.C; Chew, N.G.P.; Hegde, M.; Liu, F.; Liu, C.W.; Coronell, O.; Dingemans, T.J. (2022) Linear versus nonlinear aromatic polyamides: The role of backbone geometry in thin film salt exclusion membranes. ACS Applied Materials & Interfaces, 14, 36143–36156. DOI: 10.1021/acsami.2c09810

Fraser, AC; Yankey, J; Coronell, O; Dingemans, TJ. (2022). A Sulfonated All-Aromatic Polyamide for Heavy Metal Capture: A Model Study with Pb(II). ACS Appl Polym Mater, 5(1):856-865. DOI: 10.1021/acsapm.2c01796. PMID: 38144907; PMCID: PMC10735244.

Gavino-Lopez, N.; Eaves, L.A.; Enggasser A.E.; Fry, R.C. (2022). Developing Toxic Metal Environmental Justice Indices (TM-EJIs) for Arsenic, Cadmium, Lead, and Manganese Contamination in Private Drinking Wells in North Carolina. Water 2022, 14, 2088. DOI: 10.3390/w14132088

Grzebyk, K., Armstrong, M. D., & Coronell, O. (2022). Accessing greater thickness and new morphology features in polyamide active layers of thin-film composite membranes by reducing restrictions in amine monomer supply. Journal of Membrane Science, 120112.

Hickman E., Payton A., Duffney P., Wells H., Ceppe A.S., Brocke S., Bailey A., Rebuli M.E., Robinette C., Ring B., Rager J.E., Alexis N.E., Jaspers I. (2022). Biomarkers of Airway Immune Homeostasis Differ Significantly with Generation of E-Cigarettes. Am J Respir Crit Care Med. 2022 Nov 15;206(10):1248-1258. DOI: 10.1164/rccm.202202-0373OC. PubMed PMID: 35731626; PubMed Central PMCID: PMC9746848.

Hsiao Y.C., Liu C.W., Robinette C., Knight N., Lu K., Rebuli M.E. (2022). Development of LC-HRMS untargeted analysis methods for nasal epithelial lining fluid exposomics. J Expo Sci Environ Epidemiol. 2022 Nov;32(6):847-854. DOI: 10.1038/s41370-022-00448-3. PubMed PMID: 35750751; PubMed Central PMCID: PMC9742129.

Johnson K.J., Auerbach S.S., Stevens T., Barton-Maclaren T.S., Costa E., Currie R.A., Dalmas Wilk D., Haq S., Rager JE, Reardon A.J.F., Wehmas L., Williams A., O’Brien J., Yauk C., LaRocca J.L., Pettit S. (2022). A Transformative Vision for an Omics-Based Regulatory Chemical Testing Paradigm. Toxicol Sci. 2022 Nov 23;190(2):127-132. doi: 10.1093/toxsci/kfac097. PubMed PMID: 36165699; PubMed Central PMCID: PMC9702989.

Koval, L.E.; Carberry, C.K.; Kim, Y.H.; McDermott, E.; Hartwell, H.; Jaspers, I.; Gilmour, M.I.; Rager, J.E. (2022). Wildfire Variable Toxicity: Identifying Biomass Smoke Exposure Groupings through Transcriptomic Similarity Scoring. Environ Sci Technol 2022, 56, 23, 17131–17142. DOI: 10.1021/acs.est.2c06043

Koval L.E., Dionisio K.L., Friedman K.P., Isaacs K.K., Rager J.E. (2022). Environmental mixtures and breast cancer: identifying co-exposure patterns between understudied vs breast cancer-associated chemicals using chemical inventory informatics. J Expo Sci Environ Epidemiol. 2022 Nov;32(6):794-807. DOI: 10.1038/s41370-022-00451-8. PubMed PMID: 35710593; PubMed Central PMCID: PMC9742149.

Manning, I.M.; Chew, N.G.P.; Macdonald, H.P.; Miller, K.E.; Strynar, M.J.; Coronell, O.; Leibfarth, F.A. (2022). Hydrolytically stable ionic fluorogels for high-performance remediation of Per- and Polyfluoroalkyl Substances (PFAS) from natural water. Angewandte Chemie International Edition, 61, e202208150. DOI: 10.1002/ange.202208150

Mahung C., Stepp W.H., Long C., Malfitano M., Saklayici I., Wallet S.M., Zhou L.Y., Zhou H., Cairns B.A., Maile R. (2022). Early expression of IL-10, IL-12, ARG1, and NOS2 genes in peripheral blood mononuclear cells synergistically correlate with patient outcome after burn injury. J Trauma Acute Care Surg. 2022 Nov 1;93(5):702-711. DOI: 10.1097/TA.0000000000003602. Epub 2022 Mar 28. PubMed PMID: 35363228; PubMed Central PMCID: PMC9522922.

Miller C.T., Gray W.G., Schrefler B.A. (2022). A continuum mechanical framework for modeling tumor growth and treatment in two- and three-phase systems. Arch Appl Mech. 2022 Feb;92(2):461-489. DOI: 10.1007/s00419-021-01891-8. PubMed PMID: 35811645; PubMed Central PMCID: PMC9269988.

Peel, H.R.; Balogun, F.O.; Bowers, C.A.; Miller, C.T.; Obeidy, C.S.; Polizzotto, M.L.; Tashnia, S.U.; Vinson, D.S.; Duckworth, O.W. Towards Understanding Factors Affecting Arsenic, Chromium, and Vanadium Mobility in the Subsurface. Water 2022, 14, 3687. DOI: 10.3390/w14223687

Shang, B; Venkatratnam, A; Hartwell, H; Douillet, C; Cable, P; Liu, T; Zou, F; Ideraabdullah, FY; Fry, RC; Stýblo, M. (2022). Ex vivo exposures to arsenite and its methylated trivalent metabolites alter gene transcription in mouse sperm cells. Toxicol Appl Pharmacol, 455:116266. DOI: 10.1016/j.taap.2022.116266. PMID: 36209798; PMCID: PMC9753555.

Soares, MB; Duckworth, OW; Alleoni, LRF. (2022). The role of dissolved pyrogenic carbon from biochar in the sorption of As(V) in biogenic iron (oxyhydr)oxides. Sci Total Environ, 865:161286. DOI: 10.1016/j.scitotenv.2022.161286. PMID: 36587679; PMCID: PMC9892336.

Todero, J.E., Koch-Laskowski, K., Shi, Q., Kanke M., Hung, Y., Beck, R., Styblo, M., Sethupathy, P. (2022). Candidate master microRNA regulator of arsenic-induced pancreatic beta cell impairment revealed by multi-omics analysis. Arch Toxicol 96, 1685–1699.

Vickers, R., Weigand, T. M., Miller, C. T., & Coronell, O. (2022). Molecular methods for assessing the morphology, topology, and performance of polyamide membranes. Journal of Membrane Science, 644, 120110.

Wambaugh J.F. & Rager J.E. (2022). Exposure forecasting – ExpoCast – for data-poor chemicals in commerce and the environment. J Expo Sci Environ Epidemiol. 2022 Nov;32(6):783-793. doi: 10.1038/s41370-022-00492-z. PubMed PMID: 36347934; PubMed Central PMCID: PMC9742338.

Xenakis J.G.; Douillet C.; Bell T.A.; Hock P.; Farrington J.; Liu T.; Murphy C.E.Y.; Saraswatula A.; Shaw G.D.; Nativio G.; Shi Q.; Venkatratnam A.; Zou F.; Fry R.C.; Stýblo M.; Pardo-Manuel de Villena F. (2022). An interaction of inorganic arsenic exposure with body weight and composition on type 2 diabetes indicators in Diversity Outbred mice. Mamm Genome 2022, 33, 575-589. DOI: 10.1007/s00335-022-09957-w.

2021

Anderson, C., Fry, R.C., Hartwell, H., Kleeberger, C., Sandler, D.P., Nichols, H.B. (2021). Measurement of mitochondrial DNA copy number in dried blood spots: A pilot study. Mitochondrion. DOI: 10.1016/j.mito.2020.11.006.

Atkinson, A.J., Armstrong, M.D., Eskew, J.T., Coronell, O. (2021). 2-Aminoimidazole reduces fouling and improves membrane performance. Journal of Membrane Science. DOI: 10.1016/j.memsci.2021.119262.

Bowers, C. A., & Miller, C. T. (2021). Generalized Newtonian fluid flow in porous media. Physical Review Fluids, 6(12), 123302.

Brown, E., Nativio, G., Zhang, J., O’Shea, T., Roell, K., Hartwell, H., Fry, R.C. (2021). A comprehensive dataset of Superfund sites and their chemicals across the United States. UNC Dataverse. DOI: 10.15139/S3/4QEIGO.

Bulka, CM; Avula, V; Fry, RC. (2021) Associations of exposure to perfluoroalkyl substances individually and in mixtures with persistent infections: Recent findings from NHANES 1999-2016. Environ Pollut, 275:116619. DOI: 10.1016/j.envpol.2021.116619. PMID: 33578314; PMCID: PMC7957906.

Chang, Y., Rager, J.E., Tilton, S.C. (2021). Linking coregulated gene modules with polycyclic aromatic hydrocarbon-related cancer risk in the 3D human bronchial epithelium. Chemical Research in Toxicology. DOI: 10.1021/acs.chemrestox.0c00333.

Chi, L., Tu, P., Ru, H., Lu, K. (2021). Studies of xenobiotic-induced gut microbiota dysbiosis: from correlation to mechanisms. Gut Microbes. DOI: 10.1080/19490976.2021.1921912.

Clark, J., Avula, V., Ring, C., Eaves, L.A., Howard, T., Santos Jr, H.P., Smeester, L., Bangma, J.T., O’Shea, T.M., Fry, R.C., Rager, J.E. (2021). Comparing the predictivity of human placental gene, microRNA, and CpG methylation signatures in relation to perinatal outcomes. Toxicological Sciences. DOI: 10.1093/toxsci/kfab089.

Douillet, C.; Ji, J.; Meenakshi, I.L.; Lu K.; de Villena, F.P.; Fry, R.C.; Stýblo, M. (2021) Diverse genetic backgrounds play a prominent role in the metabolic phenotype of CC021/Unc and CC027/GeniUNC mice exposed to inorganic arsenic. Toxicology, 452:152696. DOI: 10.1016/j.tox.2021.152696. PMID: 33524430; PMCID: PMC7914223.

Escobar, Y.N.H., Morrison, C.B., Chen, Y., Hickman, E., Love, C.A., Rebuli, M.E., Surratt, J.D., Ehre, C., Jaspers, I. (2021). Differential responses to e-cig generated aerosols from humectants and different forms of nicotine in epithelial cells from non-smokers and smokers. American Journal of Physiology-Lung Cellular and Molecular Physiology. DOI: 10.1152/ajplung.00525.2020.

Ghiuzeli, C.M., Stýblo, M., Saunders, J., Calabro, A., Budman, D., Allen, S., Devoe, C., Dhingra, R. (2021). The pharmacokinetics of therapeutic arsenic trioxide in acute promyelocytic leukemia patients. Leukemia & Lymphoma. DOI: 10.1080/10428194.2021.1978084.

Gray, K. M., Triana, V., Lindsey, M., Richmond, B., Hoover, A.G., Wiesen, C. (2021). Knowledge and beliefs associated with environmental health literacy: a case study focused on toxic metals contamination of well water. International Journal of Environmental Research and Public Health. DOI: 10.3390/ijerph18179298.

Hutch C.R., Stelmak D., Kanke M., Koch-Laskowski K., Cummings B., Griffin C., Leix K., Sethupathy P., Singer K, Sandoval DA. (2021). Diet-dependent sex differences in the response to vertical sleeve gastrectomy. Am J Physiol Endocrinol Metab. 2021 Jul 1;321(1):E11-E23. DOI: 10.1152/ajpendo.00060.2021. PubMed PMID: 33998293; PubMed Central PMCID: PMC8321822.

Hung Y.H., Huang S., Dame M.K., Yu Q., Yu Q.C., Zeng Y.A., Camp J.G., Spence J.R., Sethupathy P. (2021). Chromatin regulatory dynamics of early human small intestinal development using a directed differentiation model. Nucleic Acids Res. 2021 Jan 25;49(2):726-744. DOI: 10.1093/nar/gkaa1204. PubMed PMID: 33406262; PubMed Central PMCID: PMC7826262.

Kingsbury, R., Hegde, M., Wang, J., Kusoglu, A., You, W., & Coronell, O. (2021). Tunable Anion Exchange Membrane Conductivity and Permselectivity via Non-Covalent, Hydrogen Bond Cross-Linking. ACS Applied Materials & Interfaces, 13(44), 52647-52658.

Liu Y, Wu Y, Zhang J, Zhou H. Cox regression analysis for distorted covariates with an unknown distortion function. Biom J. 2021 Jun;63(5):968-983. doi: 10.1002/bimj.202000209. Epub 2021 Mar 9. PubMed PMID: 33687092; PubMed Central PMCID: PMC8691206.

Manuck, T.A., Lai, M. Y., Hongyu, R.U., Glover, A.V., Rager, J. E., Fry, R.C., Lu, K. (2021). Metabolites from mid-trimester plasma of pregnant patients at high-risk for preterm birth. American Journal of Obstetrics & Gynecology MFM. DOI: 10.1016/j.ajogmf.2021.100393.

O’Connor S., Murphy E.A., Szwed S.K., Kanke M., Marchildon F., Sethupathy P., Darnell R.B., Cohen P. (2021). AGO HITS-CLIP reveals distinct miRNA regulation of white and brown adipose tissue identity. Genes Dev. 2021 May 1;35(9-10):771-781. DOI: 10.1101/gad.345447.120. Epub 2021 Apr 8. PubMed PMID:
33832988; PubMed Central PMCID: PMC8091975.

Rebuli, M.E., Glista-Baker, E., Hoffman, J.R., Duffney, P.F., Robinette, C., Speen, A.M., Pawlak, E.A., Dhingra, R., Noah, T.L., Jaspers, I. (2021). Electronic-cigarette use alters nasal mucosal immune response to live-attenuated influenza virus. A clinical trial. American Journal of Respiratory Cell and Molecular Biology. DOI: 10.1165/rcmb.2020-0164OC.

Rebuli, M.E., Brocke, S.A., Jaspers, I. (2021). Impact of inhaled pollutants on response to viral infection in controlled exposures. Journal of Allergy and Clinical Immunology. DOI: 10.1016/j.jaci.2021.07.002.

Ring, C., Sipes, N. S., Hsieh, J. H., Carberry, C., Koval, L. E., Klaren, W. D., Harriam M.A., Auerbach, S.S., Rager, J.E. (2021). Predictive modeling of biological responses in the rat liver using in vitro Tox21 bioactivity: Benefits from high-throughput toxicokinetics. Computational Toxicology. DOI: 10.1016/j.comtox.2021.100166.

Ryan, N.M., Hess, J.A., Pardo-Manuel de Villena, F., Leiby, B.E., Shimada, A., Yu, Lei., Yarmahmoodi, A., Petrovsky N., Zhan B., Bottazi, M.E., Makepeace, B.L., Lustigman, S., Abraham, D. (2021). Onchocerca volvulus bivalent subunit vaccine induces protective immunity in genetically diverse collaborative cross recombinant inbred intercross mice. npj Vaccines. DOI: 10.1038/s41541-020-00276-2.

Santos Jr, H.P., Bhattacharya, A., Joseph, R.M., Smeester, L., Kuban, K.C.K., Marsit, C.J., O’Shea, T.M., Fry, R.C. (2021). Evidence for the placenta-brain axis: multi-omic kernel aggregation predicts intellectual and social impairment in children born extremely preterm. Molecular Autism. DOI: 10.1186/s13229-020-00402-w.

Shanahan M.T., Kanke M., Oyesola O.O., Hung Y.H., Koch-Laskowski K., Singh A.P., Peck B.C.E., Biraud M., Sheahan B., Cortes J.E., Gong H., Sahoo D.K., Cubitt R., Kurpios N.A., Mochel J.P., Allenspach K., McElroy S.J., Ding S., von Moltke J., Dekaney C.M., Tait-Wojno E.D., Sethupathy P. (2021). Multiomic analysis defines the first microRNA atlas across all small intestinal epithelial lineages and reveals novel markers of almost all major cell types. Am J Physiol Gastrointest Liver Physiol. 2021 Dec 1;321(6):G668-G681. DOI: 10.1152/ajpgi.00222.2021. PubMed PMID: 34643097; PubMed Central PMCID: PMC8887887.

Smith G.J., Tovar A., Kanke M., Wang Y., Deshane J.S., Sethupathy P., Kelada S.N.P. (2021). Ozone-induced changes in the murine lung extracellular vesicle small RNA landscape. Physiol Rep. 2021 Sep;9(18):e15054. DOI: 10.14814/phy2.15054. PubMed PMID: 34558223; PubMed Central PMCID: PMC8461034.

Stone, J., Sutrave, P., Gasciogne, E., Givens, M.B., Fry, R.C., Manuck, T.A. (2021). Exposure to toxic metals and per- and polyfluoroalkyl substances (PFAS) and the risk of preeclampsia and preterm birth in the United States: A Review. American Journal of Obstetrics & Gynecology MFM. DOI: 10.1016/j.ajogmf.2021.100308.

Stýblo, M., Venkatratnam, A., Fry, R.C., Thomas, D.J. (2021). Origins, fate, and actions of methylated trivalent metabolites of inorganic arsenic: progress and prospects. Archives of Toxicology. DOI: 10.1007/s00204-021-03028-w.

Swahari V., Nakamura A., Hollville E., Stroud H., Simon J.M., Ptacek T.S., Beck M.V., Flowers C., Guo J., Plestant C., Liang J., Kurtz C.L., Kanke M., Hammond S.M., He Y.W., Anton E.S., Sethupathy P., Moy S.S., Greenberg M.E., Deshmukh M. (2021). MicroRNA-29 is an essential regulator of brain maturation through regulation of CH methylation. Cell Rep. 2021 Apr 6;35(1):108946. DOI: 10.1016/j.celrep.2021.108946. PubMed PMID: 33826889; PubMed Central PMCID: PMC8103628.

van der Lelie D., Oka A., Taghavi S., Umeno J., Fan T.J., Merrell K.E., Watson S.D., Ouellette L., Liu B., Awoniyi M., Lai Y., Chi L., Lu K., Henry C.S., Sartor R.B. (2021). Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis. Nat Commun. 2021 May 28;12(1):3105. DOI: 10.1038/s41467-021-23460-x. PubMed PMID: 34050144; PubMed Central PMCID: PMC8163890.

Wang, J., Armstrong, M.D., Grzebyk, K., Vickers, R., Coronell, O. (2021). Effect of feed water pH on the partitioning of alkali metal salts from aqueous phase into the polyamide active layers of reverse osmosis membranes. Environmental Science & Technology. DOI: 10.1021/acs.est.oco614o.

Wang X., Zhang W., Yang Y., Wang J., Qiu H., Liao L., Oikawa T., Wauthier E., Sethupathy P, Reid L.M., Liu Z., He Z. (2021). A MicroRNA-Based Network Provides Potential Predictive Signatures and Reveals the Crucial Role of PI3K/AKT Signaling for Hepatic Lineage Maturation. Front Cell Dev Biol . 2021;9:670059. DOI: 10.3389/fcell.2021.670059. eCollection 2021. PubMed PMID: 34141708; PubMed Central PMCID:PMC8204022.

Whitaker, A.H., Austin, R.E., Holden, K.L., Jones, J.L., Michel, F.M., Peak, D., Thompson, A., Duckworth, O.W. (2021). The structure of natural biogenic iron (oxyhydr)oxides formed in circumneutral pH environments. Geochimica et Cosmochimica Acta. DOI: 10.1016/j.gca.2021.05.059.

Xue, J., Chi, L., Tu, P., Lai, Y., Liu, C.W., Ru, H., Lu, K. (2021). Detection of gut microbiota and pathogen produced N-acyl homoserine in host circulation and tissues. npj Biofilms and Microbiomes. DOI: 10.1038/s41522-021-00224-5

Yang, Y; Chi, L; Lai, Y; Hsiao, YC; Ru, H; Lu, K. (2021) The gut microbiome and arsenic-induced disease-iAs metabolism in mice. Curr Environ Health Rep., 8(2):89-97. DOI: 10.1007/s40572-021-00305-9. PMID: 33852125; PMCID: PMC8728881.

Zhang J., Zhou H., Liu Y., Cai J. (2021). Conditional screening for ultrahigh-dimensional survival data in case cohort studies. Lifetime Data Anal. 2021 Oct;27(4):632-661. DOI: 10.1007/s10985-021-09531-7. PubMed PMID: 34417679; PubMed Central PMCID: PMC8561435.

Zhang W., Lanzoni G., Hani H., Overi D., Cardinale V., Simpson S., Pitman W., Allen A., Yi X., Wang X., Gerber D., Prestwich G., Lozoya O., Gaudio E., Alvaro D., Tokaz D., Dominguez-Bendala J., Adin C., Piedrahita J., Mathews K., Sethupathy P., Carpino G., He Z., Wauthier E., Reid L.M. (2021). Patch grafting, strategies for transplantation of organoids into solid organs such as liver. Biomaterials. 2021 Oct;277:121067. DOI: 10.1016/j.biomaterials.2021.121067. PubMed PMID: 34517276; PubMed Central PMCID: PMC8826591.

Zhou Q., Cai J., Zhou H. Semiparametric regression analysis of case-cohort studies with multiple interval censored disease outcomes. (2021). Stat Med. 2021 Jun 15;40(13):3106-3123. DOI: 10.1002/sim.8962. PubMed PMID: 33783001; PubMed Central PMCID: PMC8691208.

2020

Douillet, C., Koller, B.H., Stýblo, M. (2020). Metabolism of Inorganic Arsenic in Mice Lacking Genes Encoding GST-P, GST-M, and GST-T. Chemical Research in Toxicology, 33(8), 2043-2046. DOI: 10.1021/acs.chemrestox.0c00273.

Eaves, L.A.; Nguyen, H.T.; Rager, J.E.; Sexton, K.G.; Howard, T.; Smeester, L.; Freedman, A.N.; Aagaard, K.M.; Shope, C.; Lefer, B.; Flynn, J.H.; Erickson, M.H.; Fry, R.C.; Vizuete, W. Identifying the Transcriptional Response of Cancer and Inflammation-Related Genes in Lung Cells in Relation to Ambient Air Chemical Mixtures in Houston, Texas. (2020). Environ Sci Technol. 2020 Nov 3;54(21):13807-13816. DOI: 10.1021/acs.est.0c02250. PubMed PMID: 33064461; PubMed Central PMCID: PMC7757424.

Eaves L.A., Phookphan P., Rager J.E., Bangma J., Santos H.P. Jr, Smeester L., O’Shea T.M., Fry R.C. A role for microRNAs in the epigenetic control of sexually dimorphic gene expression in the human placenta. (2020) Epigenomics. 2020 Sep;12(17):1543-1558. doi: 10.2217/epi-2020-0062. PubMed PMID: 32901510; PubMed Central PMCID: PMC7607407.

Gray, K.M., LePrevost, C.E., Cope, W.G. (2020). Anglers’ Views on Using Signs to Communicate Fish Consumption Advisories. Fisheries, 45(10), 307-316. DOI: 10.1002/fsh.10463.

Gu, B., Shorter, J.R., Williams, L.H., Bell, T.A., Hock, P. Dalton, K.A., Pan, Y., Miller, D.R., Shaw, G.D., Philpot, B.D., Pardo-Manuel de Villena, F. (2020). Collaborative Cross mice reveal extreme epilepsy phenotypes and genetic loci for seizure susceptibility. Epilepsia, 61(9), 2010-2021. DOI: 10.1111/epi.16617.

Hillis D.A., Yadgary L., Weinstock G.M., Pardo-Manuel de Villena F., Pomp D., Fowler A.S., Xu S., Chan F., Garland T. Jr. Genetic Basis of Aerobically Supported Voluntary Exercise: Results from a Selection Experiment with House Mice. Genetics. 2020 Nov;216(3):781-804. DOI: 10.1534/genetics.120.303668. PubMed PMID: 32978270; PubMed Central PMCID: PMC7648575.

Huda M.N., VerHague M., Albright J., Smallwood T., Bell T.A., Que E., Miller D.R., Roshanravan B., Allayee H., Manuel de Villena F.P., Bennett B.J. Dissecting the Genetic Architecture of Cystatin C in Diversity Outbred Mice. (2020). G3 (Bethesda). 2020 Jul 7;10(7):2529-2541. DOI: 10.1534/g3.120.401275. PubMed PMID: 32467129; PubMed Central PMCID: PMC7341122.

Lebow-Skelley, E., Yelton, S., Janssen, B., Erdei, E., Pearson, M.A. (2020). Identifying Issues and Priorities in Reporting Back Environmental Health Data. International Journal of Environmental Research and Public Health, 17(18), 6742. DOI: 10.3390/ijerph17186742.

Li, Y.Y., Douillet, C., Huang, M., Beck, R., Sumner, S.J., Stýblo, M. (2020). Exposure to inorganic arsenic and its methylated metabolites alters metabolomics profiles in INS-1 832/13 insulinoma cells and isolated pancreatic islets. Archives of Toxicology, 94(6), 1955-1972. DOI: 10.1007/s00204-020-02729-y.

Payton A., Clark J., Eaves L., Santos H.P. Jr, Smeester L., Bangma J.T., O’Shea T.M., Fry R.C., Rager J.E. Placental genomic and epigenomic signatures associated with infant birth weight highlight mechanisms involved in collagen and growth factor signaling. (2020). Reprod Toxicol. 2020 Sep;96:221-230. DOI: 10.1016/j.reprotox.2020.07.007. PubMed PMID: 32721520; PubMed Central PMCID: PMC7855285.

Rockwood, S., Rogala, A.R., Saraswatula, A., Sassetti, C.M., Schisler, J.C., Schoenrock, S.A., Shaw, G.D., Shorter, J.R., Smith, C.M., St. Pierre, C.L., Tarantino, L.M., Threadgill, D.W., Sigmon, J.S., Blanchard, M.W., Baric, R.S., Bell, T.A., Brennan, J., Brockmann, G.A., Burks, A.W., Calabrese, J.M., Caron, K.M., Cheney, R.E., Ciavatta, D., Conlon, F., Darr, D.B., Faber, J., Franklin, C., Gershon, T.R., Gralinski, L., Gu, B., Gaines, C.H., Hagan, R.S., Heimsath, E.G., Heise, M.T., Hock, P., Ideraabdullah, F., Jennette, J.C., Kafri, T., Kashfeen, A., Kulis, M., Kumar, V., Linnertz, C., Livraghi-Butrico, A., Lloyd, K.C.K., Lutz, C., Lynch, R.M., Magnuson, T., Matsushima, G.K., McMullan, R., Miller, D.R., Mohlke, K.L., Moy, S.S., Murphy, C.E.Y., Najarian, M., O’Brien, L., Palmer, A.A., Philpot, B.D., Randell, S.H., Reinholdt, L., Ren, Y., Venkatratnam, A., Douillet, C., Topping, B.C., Shi, Q., Addo, K.A., Ideraabdullah, F.Y., Fry, R.C., Stýblo, M. (2020). Sex-dependent effects of preconception exposure to arsenite on gene transcription in parental germ cells and on transcriptomic profiles and diabetic phenotype of offspring. Archives of Toxicology. DOI: 10.1007/s00204-020-02941-w.

Valdar, W., Vilen, B.J., Wardwell, K., Whitmire, J.K., Williams, L., Zylka, M.J., Ferris, M.T., McMillan, L., Pardo-Manuel de Villena, F. (2020). Content and Performance of the MiniMUGA Genotyping Array, a New Tool To Improve Rigor and Reproducibility in Mouse Research. Genetics, 216(4), 905-930. DOI: 10.1534/genetics.120.303596.

Wang T., Wang X., George S.L., Zhou H. Design and analysis of biomarker-integrated clinical trials with adaptive threshold detection and flexible patient enrichment. (2020). J Biopharm Stat. 2020 Nov 1;30(6):1060-1076. DOI: 10.1080/10543406.2020.1832110. PubMed PMID: 33175640; PubMed Central PMCID: PMC7954851.

Yu, W., Hill, S.F., Xenakis, J.G., Pardo-Manuel de Villena, F., Wagnon, J.L., Meisler, M.H. (2020). Gabra2 is a genetic modifier of Scn8a encephalopathy in the mouse. Epilepsia, 61(12), 2847-2856. DOI: 10.1111/epi.16741.

Yu J., Zhou H., Cai J. Accelerated failure time model for data from outcome-dependent sampling. (2021). Lifetime Data Anal. 2021 Jan;27(1):15-37. DOI: 10.1007/s10985-020-09508-y. PubMed PMID: 33044612; PubMed Central PMCID: PMC7856009.

Zhang, J.; Zhou, H.; Liu, Y.; Cai, J. (2020) Feature screening for case-cohort studies with failure time outcome. Scandinavian Journal of Statistics 2021, 48(1):349-370. DOI: 10.1111/sjos.12503. PMID: 35811582; PMCID: PMC9269537.

CONTACT INFORMATION

Director: Rebecca Fry, PhD
Deputy Director: Fernando Pardo-Manuel de Villena, PhD
Funding provided by NIEHS grant #P42 ES031007

135 Dauer Drive
253 Rosenau Hall, CB #7431
Chapel Hill, NC, 27599-7431