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Reflections from the Well is the e-newsletter of the UNC Superfund Research Program. It is issued quarterly and features significant program accomplishments and highlights the work of several projects and cores in each issue. The newsletter is distributed to elected officials, environmental and community-based organizations, various governmental contacts, other SRPs, etc.

Volume 9

Volume 8

Volume 7

Volume 6

Volume 5

Volume 4

Volume 3

Volume 2

Volume 1

Peer-reviewed Publications


Obeidy, CS; Polizzotto, ML. (2024) Understanding the influence of soil development on contaminant reactivity along a fluvial chronosequence in the Oregon Coast Range. Geoderma, Volume 442, 2024, 116784. DOI: 10.1016/j.geoderma.2024.116784.

Wilson, L; Hayes, WJ; Jones, CN; Eaves, L; Wait, K; George, A; Freeman, B; Mize, W; Fowlkes, J; Currie, J; Burchell, M; Gray, K; Fry, R; Pieper, KJ. (2024) Lead occurrence in North Carolina well water: Importance of sampling representation and collection techniques. Environmental Research Letters.  DOI: 10.1088/1748-9326/ad2b2c.

Alvarado, TR; Austin, RE; Bradley, PJ; Eaves, LA; Fry, RC; George, A; Gray, KM; Osborne, JA; Stýblo, M; Vinson, DS; Duckworth, OW. (2024) Geologic Predictors of Drinking Water Well Contamination in North Carolina. PLOS Water, 3: e0000194. DOI: 10.1371/journal.pwat.0000194.


Yang, Y; Chi, L; Liu, CW; Hsiao, YC; Lu, K. (2023) Chronic Arsenic Exposure Perturbs Gut Microbiota and Bile Acid Homeostasis in Mice. Chem Res Toxicol, 36(7):1037-1043. DOI: 10.1021/acs.chemrestox.2c00410. PMID: 37295807; PMCID: PMC10773974.

Yang, Y; Hsiao, YC; Liu, CW; Lu, K. (2023) The Role of the Nuclear Receptor FXR in Arsenic-Induced Glucose Intolerance in Mice. Toxics. DOI: 10.3390/toxics11100833. PMID: 37888683; PMCID: PMC10611046.

Soares, MB; Duckworth, OW; Stýblo, M; Cable, PH; Alleoni, LRF. (2023) Pyrolysis temperature and biochar redox activity on arsenic availability and speciation in a sediment. J Hazard Mater. DOI: 10.1016/j.jhazmat.2023.132308. PMID: 37639794; PMCID: PMC10528781.

Carberry, CK; Bangma, J; Koval, L; Keshava, D; Hartwell, HJ; Sokolsky, M; Fry, RC; Rager, JE. (2023) Extracellular Vesicles altered by a Per- and Polyfluoroalkyl Substance Mixture: In Vitro Dose-Dependent Release, Chemical Content, and MicroRNA Signatures involved in Liver Health. Toxicol Sci. DOI: 10.1093/toxsci/kfad108. PMID: 37851381.

Shang, B; Venkatratnam, A; Liu, T; Douillet, C; Shi, Q; Miller, M; Cable, P; Zou, F; Ideraabdullah, FY; Fry, RC; Stýblo, M. (2023) Sex-specific transgenerational effects of preconception exposure to arsenite: metabolic phenotypes of C57BL/6 offspring. Arch Toxicol, 97(11):2879-2892. DOI: 10.1007/s00204-023-03582-5. PMID: 37615676; PMCID: PMC10754030.

Zhang W, Chew NGP, Coronell O. (2023) Facile Synthesis of Electrically Conductive Membranes. Environ Sci Technol Lett, 10(11):1135-1141. DOI: 10.1021/acs.estlett.3c00631. PMID: 38144434; PMCID: PMC10735243.

Todero, J; Douillet, C; Shumway, AJ; Koller, BH; Kanke, M; Phuong, DJ; Stýblo, M; Sethupathy, P. (2023) Molecular and Metabolic Analysis of Arsenic-Exposed Humanized AS3MT Mice. Environmental Health Perspectives, 131(12), 127021. DOI: 10.1289/EHP12785.

Eaves, LA; Keil, AP; Jukic, AM; Dhingra, R; Brooks, JL; Manuck, TA; Rager, JEFry, RC. (2023) Toxic metal mixtures in private well water and increased risk for preterm birth in North Carolina. Environmental Health, 22(1), 69. DOI: 10.1186/s12940-023-01021-7.

Perry, LA; Chew, NGP; Grzebyk, K; Cay-Durgun, P; Lind, ML; Sitaula, P; Soukri, M; Coronell, O. Correlating the Role of Nanofillers with Active Layer Properties and Performance of Thin-Film Nanocomposite Membranes. Desalination, 550. DOI: 10.1016/j.desal.2023.116370. PMID: 37274380; PMCID: PMC10237506.

Balogun, F; Aiken, M; Namayandeh, A; Duckworth, OW; Polizzotto, ML. (2023) Dissolved organic carbon diminishes manganese oxide-driven oxidation of chromium. Chemosphere, 344, 140424. DOI: 10.1016/j.chemosphere.2023.140424

Gray, K.M.; Blanchard, M.R.; LePrevost, C.E. | Li, F. (reviewing editor). (2023) Educator beliefs and organizational constraints: Factors that influence informal education about fish consumption advisories in a southeastern US state. Sustainable Environment, 9(1). DOI: 10.1080/27658511.2023.2259716

Eaves, L.A.; Choi, G.; Hall, E.; Sille, F.C.M.; Fry, R.C; Buckley, J.P.; Keil, A.P. (2023). Prenatal Exposure to Toxic Metals and Neural Tube Defects: A Systematic Review of the Epidemiologic Evidence. Environmental Health Perspectives, 131(8). DOI: 10.1289/EHP11872

Shang, B.; Venkatratnam, A.; Liu, T.; Douillet, C.; Shi, Q.; Miller, M.; Cable, P.; Zou, F.; Ideraabdullah, F.Y.; Fry, R.C.; Stýblo, M. (2023). Sex-specific transgenerational effects of preconception exposure to arsenite: metabolic phenotypes of C57BL/6 offspring. Arch Toxicol, 97(11):2879-2892. DOI: 10.1007/s00204-023-03582-5. Epub 2023 Aug 24. PMID: 37615676.

George, A.; Gray, K.; Wait, K.; Gallagher, D.; Edwards, M.; Currie, J.; Hogan, J.; Kwasikpui, A.W.; Pieper, K.J. (2023) Drinking Water Disparities in North Carolina Communities Served by Private Wells. Environmental Justice, DOI: 10.1089/env.2022.0100

Eaves, L.A.; Fry, R.C. (2023). Invited Perspective: Toxic Metals and Hypertensive Disorders of Pregnancy. Environmental Health Perspectives, 131(4). DOI:

Freedman, A.N.; Clark, J.; Eaves, L.A.; Roell, K.; Oran, A.; Koval, L.; Rager, J.; Santos, H.P. Jr.; Kuban, K.; Joseph, R.M.; Frazier, J.; Marsit, C.J.; Burt, A.A.; O’Shea, T.M.; Fry, R.C. (2023). A multi-omic approach identifies an autism spectrum disorder (ASD) regulatory complex of functional epimutations in placentas from children born preterm. Autism Res, 16(5):918-934. DOI: 10.1002/aur.2915. PMID: 36938998; PMCID: PMC10192070.

Yelton, S.; George, A.; Tomlinson, M.S.; Bommarito, P.A.; Fry, R.C.; Gray, K.M. (2023). Communicating results of drinking water tests from private wells: Designing report-back materials to facilitate understanding. Journal of Environmental Health, 85(8), 8-14.

Medina, S.; Zhang, H.; Santos-Medina, L.V.; Yee, Z.A.; Martin, K.J.; Wan, G.; Bolt, A.M.; Zhou, X.; Stýblo, M.; Liu, K.J. (2023) Arsenite Methyltransferase Is an Important Mediator of Hematotoxicity Induced by Arsenic in Drinking WaterWater 2023, 15, 448. DOI: 10.3390/w15030448

Eaves, L.A.; Lanier P.; Enggasser A.E.; Chung G.; Turla T.; Rager J.E., Fry R.C. (2023) Generation of the Chemical and Social Stressors Integration Technique (CASS-IT) to identify areas of holistic public health concern: An application to North Carolina. Science of The Total Environment 2023, 862, 409. DOI: 10.1016/j.scitotenv.2022.160409

Douillet C.; Miller M.; Cable P.H.; Shi Q.; El‐Masri H.; Matoušek T.; Koller B.H.; Thomas D.J.; Stýblo M. (2023) Fate of arsenicals in mice carrying the human AS3MT gene exposed to environmentally relevant levels of arsenite in drinking water. Scientific Reports 2023, 13, 3360. DOI: 10.1038/s41598-023-30723-8

Cheng X, An J, Lou J, Gu Q, Ding W, Droby G, Wang Y, Wang C, Gao Y, Shelton A, Satterlee AB, Mann BE, Hsiao YC, Liu CW, Liu K, Hingtgen S, Wang J, Liu Z, Miller R, Wu D, Vaziri C, Yang Y. Trans-Lesion Synthesis and Mismatch Repair Pathway Crosstalk Defines Chemoresistance and Hypermutation Mechanisms in Glioblastoma. Res Sq. 2023 Oct 16;. doi: 10.21203/ PubMed PMID: 37886584; PubMed Central PMCID: PMC10602147.

Ji M, Xu X, Xu Q, Hsiao YC, Martin C, Ukraintseva S, Popov V, Arbeev KG, Randall TA, Wu X, Garcia-Peterson LM, Liu J, Xu X, Andrea Azcarate-Peril M, Wan Y, Yashin AI, Anantharaman K, Lu K, Li JL, Shats I, Li X. Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota. Nat Metab. 2023 Sep;5(9):1526-1543. doi: 10.1038/s42255-023-00854-3. Epub 2023 Aug 3. PubMed PMID: 37537369; PubMed Central PMCID: PMC10513933.

Fashe MM, Miner TA, Fallon JK, Schauer AP, Sykes C, Smith PC, Lee CR. Pregnancy related hormones increase CYP3A mediated buprenorphine metabolism in human hepatocytes: a comparison to CYP3A substrates nifedipine and midazolam. Front Pharmacol. 2023;14:1218703. doi: 10.3389/fphar.2023.1218703. eCollection 2023. PubMed PMID: 37475714; PubMed Central PMCID: PMC10354249.

Yan F, Liu Y, Cai J, Zhou H. Estimated quadratic inference function for correlated failure time data. Biometrics. 2023 Jun;79(2):1145-1158. doi: 10.1111/biom.13633. Epub 2022 Mar 9. PubMed PMID: 35146750; PubMed Central PMCID: PMC9365883.

Hsiao YC, Matulewicz RS, Sherman SE, Jaspers I, Weitzman ML, Gordon T, Liu CW, Yang Y, Lu K, Bjurlin MA. Untargeted Metabolomics to Characterize the Urinary Chemical Landscape of E-Cigarette Users. Chem Res Toxicol. 2023 Apr 17;36(4):630-642. doi: 10.1021/acs.chemrestox.2c00346. Epub 2023 Mar 13. PubMed PMID: 36912507; PubMed Central PMCID: PMC10371198.


Shang, B; Venkatratnam, A; Hartwell, H; Douillet, C; Cable, P; Liu, T; Zou, F; Ideraabdullah, FY; Fry, RCStýblo, M. (2022) Ex vivo exposures to arsenite and its methylated trivalent metabolites alter gene transcription in mouse sperm cells. Toxicol Appl Pharmacol, 455:116266. DOI: 10.1016/j.taap.2022.116266. PMID: 36209798; PMCID: PMC9753555.

Duckworth, OW; Polizzotto, ML; Thompson, A. Bringing soil chemistry to environmental health science to tackle soil contaminants. (2022) Front Environ Sci. DOI: 10.3389/fenvs.2022.981607. PMID: 36407845; PMCID: PMC9673486.

Eaves, LA; Bulka, CM; Rager, JE; Gardner, AJ; Galusha, AL; Parsons, PJ; O’Shea, TM; Fry, RC. (2022) Metal mixtures modeling identifies birth weight-associated gene networks in the placentas of children born extremely preterm. Chemosphere, 313:137469. DOI: 10.1016/j.chemosphere.2022.137469.  PMID: 36493891; PMCID: PMC10476282.

Fraser, AC; Yankey, J; Coronell, O; Dingemans, TJ. (2022) A Sulfonated All-Aromatic Polyamide for Heavy Metal Capture: A Model Study with Pb(II). ACS Appl Polym Mater, 5(1):856-865. DOI: 10.1021/acsapm.2c01796. PMID: 38144907; PMCID: PMC10735244.

Alowaifeer, AM; Clingenpeel, S; Kan, J; Bigelow, PE; Yoshinaga, M; Bothner, B; McDermott, TR. (2022) Arsenic and Mercury Distribution in an Aquatic Food Chain: Importance of Femtoplankton and Picoplankton Filtration Fractions. Environ Toxicol Chem., 42(1):225-241. DOI: 10.1002/etc.5516. PMID: 36349954; PMCID: PMC10753857.

Soares, MB; Duckworth, OW; Alleoni, LRF.  (2022) The role of dissolved pyrogenic carbon from biochar in the sorption of As(V) in biogenic iron (oxyhydr)oxides. Sci Total Environ, 865:161286. DOI: 10.1016/j.scitotenv.2022.161286. PMID: 36587679; PMCID: PMC9892336.

Koval, L.E.; Carberry, C.K.; Kim, Y.H.; McDermott, E.; Hartwell, H.; Jaspers, I.; Gilmour, M.I.; Rager, J.E. Wildfire Variable Toxicity: Identifying Biomass Smoke Exposure Groupings through Transcriptomic Similarity Scoring. Environ Sci Technol 2022, 56, 23, 17131–17142. DOI: 10.1021/acs.est.2c06043

Gavino-Lopez, N.; Eaves, L.A.; Enggasser A.E.; Fry, R.C. Developing Toxic Metal Environmental Justice Indices (TM-EJIs) for Arsenic, Cadmium, Lead, and Manganese Contamination in Private Drinking Wells in North Carolina. Water 2022, 14, 2088. DOI: 10.3390/w14132088

Peel, H.R.; Balogun, F.O.; Bowers, C.A.; Miller, C.T.; Obeidy, C.S.; Polizzotto, M.L.; Tashnia, S.U.; Vinson, D.S.; Duckworth, O.W. Towards Understanding Factors Affecting Arsenic, Chromium, and Vanadium Mobility in the Subsurface. Water 2022, 14, 3687. DOI: 10.3390/w14223687

Carberry, C.K.; Rager, J.E. (2022) The impact of environmental contaminants on extracellular vesicles and their key molecular regulators: A literature and database-driven review. Environmental and Molecular Mutagenesis 2022. 64, 2522. DOI: 10.1002/em.22522

Xenakis J.G.; Douillet C.; Bell T.A.; Hock P.; Farrington J.; Liu T.; Murphy C.E.Y.; Saraswatula A.; Shaw G.D.; Nativio G.; Shi Q.; Venkatratnam A.; Zou F.; Fry R.C.; Stýblo M.; Pardo-Manuel de Villena F. (2022) An interaction of inorganic arsenic exposure with body weight and composition on type 2 diabetes indicators in Diversity Outbred mice. Mamm Genome 2022, 33, 575-589. DOI: 10.1007/s00335-022-09957-w

Armstrong, M.D.; Vickers, R.; Coronell, O. (2022) Trends and errors in reverse osmosis membrane performance calculations stemming from test pressure and simplifying assumptions about concentration polarization and solute rejection. Journal of Membrane Science, 660, 120856. DOI:10.1016/j.memsci.2022.120856  

Armstrong, M.D.; Vickers, R.; Coronell, O. (2022) Dataset of reverse osmosis membrane transport properties calculated with and without assumptions about concentration polarization and solute rejection and the errors associated with each assumption. Data in Brief, 44, 108538. DOI: 10.1016/j.dib.2022.108538 

Manning, I.M.; Chew, N.G.P.; Macdonald, H.P.; Miller, K.E.; Strynar, M.J.; Coronell, O.; Leibfarth, F.A. (2022) Hydrolytically stable ionic fluorogels for high-performance remediation of Per- and Polyfluoroalkyl Substances (PFAS) from natural water. Angewandte Chemie International Edition, 61, e202208150. DOI: 10.1002/ange.202208150 

Fraser, A.C; Chew, N.G.P.; Hegde, M.; Liu, F.; Liu, C.W.; Coronell, O.; Dingemans, T.J. (2022) Linear versus nonlinear aromatic polyamides: The role of backbone geometry in thin film salt exclusion membranes. ACS Applied Materials & Interfaces, 14, 36143–36156. DOI: 10.1021/acsami.2c09810 

Avery C. L., Howard A. G., Ballou A. F., Buchanan V. L., Collins J. M., Downie C. G., Engel S. M., Graff M., Highland H. M., Lee M. P., Lilly A. G., Lu K., Rager J. E., Staley B. S., North K. E., Gordon-Larsen P. (2022). Strengthening Causal Inference in Exposomics Research: Application of Genetic Data and Methods. Environ Health Perspect. DOI: 10.1289/EHP9098.

Todero, J.E., Koch-Laskowski, K., Shi, Q., Kanke M., Hung, Y., Beck, R., Styblo, M., Sethupathy, P. (2022). Candidate master microRNA regulator of arsenic-induced pancreatic beta cell impairment revealed by multi-omics analysis. Arch Toxicol 96, 1685–1699.

Eaves, L. A., Keil, A. P., Rager, J. E., George, A., & Fry, R. C. (2022). Analysis of the novel NCWELL database highlights two decades of co-occurrence of toxic metals in North Carolina private well water: Public health and environmental justice implications. Science of The Total Environment, 151479.

Grzebyk, K., Armstrong, M. D., & Coronell, O. (2022). Accessing greater thickness and new morphology features in polyamide active layers of thin-film composite membranes by reducing restrictions in amine monomer supply. Journal of Membrane Science, 120112.

Vickers, R., Weigand, T. M., Miller, C. T., & Coronell, O. (2022). Molecular methods for assessing the morphology, topology, and performance of polyamide membranes. Journal of Membrane Science, 644, 120110.

Johnson KJ, Auerbach SS, Stevens T, Barton-Maclaren TS, Costa E, Currie RA, Dalmas Wilk D, Haq S, Rager JE, Reardon AJF, Wehmas L, Williams A, O’Brien J, Yauk C, LaRocca JL, Pettit S. A Transformative Vision for an Omics-Based Regulatory Chemical Testing Paradigm. Toxicol Sci. 2022 Nov 23;190(2):127-132. doi: 10.1093/toxsci/kfac097. PubMed PMID: 36165699; PubMed Central PMCID: PMC9702989.

Hickman E, Payton A, Duffney P, Wells H, Ceppe AS, Brocke S, Bailey A, Rebuli ME, Robinette C, Ring B, Rager JE, Alexis NE, Jaspers I. Biomarkers of Airway Immune Homeostasis Differ Significantly with Generation of E-Cigarettes. Am J Respir Crit Care Med. 2022 Nov 15;206(10):1248-1258. doi: 10.1164/rccm.202202-0373OC. PubMed PMID: 35731626; PubMed Central PMCID: PMC9746848.

Wambaugh JF, Rager JE. Exposure forecasting – ExpoCast – for data-poor chemicals in commerce and the environment. J Expo Sci Environ Epidemiol. 2022 Nov;32(6):783-793. doi: 10.1038/s41370-022-00492-8. Epub 2022 Nov 8. Review. PubMed PMID: 36347934; PubMed Central PMCID: PMC9742338.

Mahung C, Stepp WH, Long C, Malfitano M, Saklayici I, Wallet SM, Zhou LY, Zhou H, Cairns BA, Maile R. Early expression of IL-10, IL-12, ARG1, and NOS2 genes in peripheral blood mononuclear cells synergistically correlate with patient outcome after burn injury. J Trauma Acute Care Surg. 2022 Nov 1;93(5):702-711. doi: 10.1097/TA.0000000000003602. Epub 2022 Mar 28. PubMed PMID: 35363228; PubMed Central PMCID: PMC9522922.

Hsiao YC, Liu CW, Robinette C, Knight N, Lu K, Rebuli ME. Development of LC-HRMS untargeted analysis methods for nasal epithelial lining fluid exposomics. J Expo Sci Environ Epidemiol. 2022 Nov;32(6):847-854. doi: 10.1038/s41370-022-00448-3. Epub 2022 Jun 24. PubMed PMID: 35750751; PubMed Central PMCID: PMC9742129.

Koval LE, Dionisio KL, Friedman KP, Isaacs KK, Rager JE. Environmental mixtures and breast cancer: identifying co-exposure patterns between understudied vs breast cancer-associated chemicals using chemical inventory informatics. J Expo Sci Environ Epidemiol. 2022 Nov;32(6):794-807. doi: 10.1038/s41370-022-00451-8. Epub 2022 Jun 16. PubMed PMID: 35710593; PubMed Central PMCID: PMC9742149.

Carberry CK, Keshava D, Payton A, Smith GJ, Rager JE. Approaches to incorporate extracellular vesicles into exposure science, toxicology, and public health research. J Expo Sci Environ Epidemiol. 2022 Sep;32(5):647-659. doi: 10.1038/s41370-022-00417-w. Epub 2022 Feb 25. Review. PubMed PMID: 35217808; PubMed Central PMCID: PMC9402811.

Carberry CK, Ferguson SS, Beltran AS, Fry RC, Rager JE. Using liver models generated from human induced pluripotent stem cells (iPSCs) for evaluating chemical-induced modifications and disease across liver developmental stages. Toxicol In Vitro. 2022 Sep;83:105412. doi: 10.1016/j.tiv.2022.105412. Epub 2022 Jun 7. Review. PubMed PMID: 35688329; PubMed Central PMCID: PMC9296547.

Carberry CK, Koval LE, Payton A, Hartwell H, Ho Kim Y, Smith GJ, Reif DM, Jaspers I, Ian Gilmour M, Rager JE. Wildfires and extracellular vesicles: Exosomal MicroRNAs as mediators of cross-tissue cardiopulmonary responses to biomass smoke. Environ Int. 2022 Sep;167:107419. doi: 10.1016/j.envint.2022.107419. Epub 2022 Jul 16. PubMed PMID: 35863239; PubMed Central PMCID: PMC9389917.

Miller CT, Gray WG, Schrefler BA. A continuum mechanical framework for modeling tumor growth and treatment in two- and three-phase systems. Arch Appl Mech. 2022 Feb;92(2):461-489. doi: 10.1007/s00419-021-01891-8. Epub 2021 Jun 9. PubMed PMID: 35811645; PubMed Central PMCID: PMC9269988.


Yang, Y; Chi, L; Lai, Y; Hsiao, YC; Ru, H; Lu, K. (2021) The gut microbiome and arsenic-induced disease-iAs metabolism in mice. Curr Environ Health Rep., 8(2):89-97. DOI: 10.1007/s40572-021-00305-9. PMID: 33852125; PMCID: PMC8728881.

Bulka, CM; Avula, V; Fry, RC. (2021) Associations of exposure to perfluoroalkyl substances individually and in mixtures with persistent infections: Recent findings from NHANES 1999-2016. Environ Pollut, 275:116619. DOI: 10.1016/j.envpol.2021.116619. PMID: 33578314; PMCID: PMC7957906.

Douillet, C; Ji, J; Meenakshi, IL; Lu K; de Villena, FP; Fry, RC; Stýblo, M. (2021) Diverse genetic backgrounds play a prominent role in the metabolic phenotype of CC021/Unc and CC027/GeniUNC mice exposed to inorganic arsenic. Toxicology, 452:152696. DOI: 10.1016/j.tox.2021.152696. PMID: 33524430; PMCID: PMC7914223.

Bowers, C. A., & Miller, C. T. (2021). Generalized Newtonian fluid flow in porous media. Physical Review Fluids, 6(12), 123302.

Kingsbury, R., Hegde, M., Wang, J., Kusoglu, A., You, W., & Coronell, O. (2021). Tunable Anion Exchange Membrane Conductivity and Permselectivity via Non-Covalent, Hydrogen Bond Cross-Linking. ACS Applied Materials & Interfaces, 13(44), 52647-52658.

Ghiuzeli, C.M., Stýblo, M., Saunders, J., Calabro, A., Budman, D., Allen, S., Devoe, C., Dhingra, R. (2021). The pharmacokinetics of therapeutic arsenic trioxide in acute promyelocytic leukemia patients. Leukemia & Lymphoma. DOI: 10.1080/10428194.2021.1978084

Clark, J., Avula, V., Ring, C., Eaves, L.A., Howard, T., Santos Jr, H.P., Smeester, L., Bangma, J.T., O’Shea, T.M., Fry, R.C., Rager, J.E. (2021). Comparing the predictivity of human placental gene, microRNA, and CpG methylation signatures in relation to perinatal outcomes. Toxicological Sciences. DOI: 10.1093/toxsci/kfab089

Gray, K. M., Triana, V., Lindsey, M., Richmond, B., Hoover, A.G., Wiesen, C. (2021). Knowledge and beliefs associated with environmental health literacy: a case study focused on toxic metals contamination of well water. International Journal of Environmental Research and Public Health. DOI: 10.3390/ijerph18179298

Whitaker, A.H., Austin, R.E., Holden, K.L., Jones, J.L., Michel, F.M., Peak, D., Thompson, A., Duckworth, O.W. (2021). The structure of natural biogenic iron (oxyhydr)oxides formed in circumneutral pH environments. Geochimica et Cosmochimica Acta. DOI: 10.1016/j.gca.2021.05.059

Chi, L., Tu, P., Ru, H., Lu, K. (2021). Studies of xenobiotic-induced gut microbiota dysbiosis: from correlation to mechanisms. Gut Microbes. DOI: 10.1080/19490976.2021.1921912

Rebuli, M.E., Brocke, S.A., Jaspers, I. (2021). Impact of inhaled pollutants on response to viral infection in controlled exposures. Journal of Allergy and Clinical Immunology. DOI: 10.1016/j.jaci.2021.07.002

Atkinson, A.J., Armstrong, M.D., Eskew, J.T., Coronell, O. (2021). 2-Aminoimidazole reduces fouling and improves membrane performance. Journal of Membrane Science. DOI: 10.1016/j.memsci.2021.119262

Xue, J., Chi, L., Tu, P., Lai, Y., Liu, C.W., Ru, H., Lu, K. (2021). Detection of gut microbiota and pathogen produced N-acyl homoserine in host circulation and tissues. npj Biofilms and Microbiomes. DOI: 10.1038/s41522-021-00224-5

Brown, E., Nativio, G., Zhang, J., O’Shea, T., Roell, K., Hartwell, H., Fry, R.C. (2021). A comprehensive dataset of Superfund sites and their chemicals across the United States. UNC Dataverse. DOI: 10.15139/S3/4QEIGO

Escobar, Y.N.H., Morrison, C.B., Chen, Y., Hickman, E., Love, C.A., Rebuli, M.E., Surratt, J.D., Ehre, C., Jaspers, I. (2021). Differential responses to e-cig generated aerosols from humectants and different forms of nicotine in epithelial cells from non-smokers and smokers. American Journal of Physiology-Lung Cellular and Molecular Physiology. DOI: 10.1152/ajplung.00525.2020

Chang, Y., Rager, J.E., Tilton, S.C. (2021). Linking coregulated gene modules with polycyclic aromatic hydrocarbon-related cancer risk in the 3D human bronchial epithelium. Chemical Research in Toxicology. DOI: 10.1021/acs.chemrestox.0c00333

Manuck, T.A., Lai, M. Y., Hongyu, R.U., Glover, A.V., Rager, J. E., Fry, R.C., Lu, K. (2021). Metabolites from mid-trimester plasma of pregnant patients at high-risk for preterm birth. American Journal of Obstetrics & Gynecology MFM. DOI: 10.1016/j.ajogmf.2021.100393

Stýblo, M., Venkatratnam, A., Fry, R.C., Thomas, D.J. (2021). Origins, fate, and actions of methylated trivalent metabolites of inorganic arsenic: progress and prospects. Archives of Toxicology. DOI: 10.1007/s00204-021-03028-w

Ring, C., Sipes, N. S., Hsieh, J. H., Carberry, C., Koval, L. E., Klaren, W. D., Harriam M.A., Auerbach, S.S., Rager, J.E. (2021). Predictive modeling of biological responses in the rat liver using in vitro Tox21 bioactivity: Benefits from high-throughput toxicokinetics. Computational Toxicology. DOI: 10.1016/j.comtox.2021.100166

Wang, J., Armstrong, M.D., Grzebyk, K., Vickers, R., Coronell, O. (2021). Effect of feed water pH on the partitioning of alkali metal salts from aqueous phase into the polyamide active layers of reverse osmosis membranes. Environmental Science & Technology. DOI: 10.1021/acs.est.oco614o

Ryan, N.M., Hess, J.A., Pardo-Manuel de Villena, F., Leiby, B.E., Shimada, A., Yu, Lei., Yarmahmoodi, A., Petrovsky N., Zhan B., Bottazi, M.E., Makepeace, B.L., Lustigman, S., Abraham, D. (2021). Onchocerca volvulus bivalent subunit vaccine induces protective immunity in genetically diverse collaborative cross recombinant inbred intercross mice. npj Vaccines. DOI: 10.1038/s41541-020-00276-2

Anderson, C., Fry, R.C., Hartwell, H., Kleeberger, C., Sandler, D.P., Nichols, H.B. (2021). Measurement of mitochondrial DNA copy number in dried blood spots: A pilot studyMitochondrion. DOI: 10.1016/j.mito.2020.11.006

Stone, J., Sutrave, P., Gasciogne, E., Givens, M.B., Fry, R.C., Manuck, T.A. (2021). Exposure to toxic metals and per- and polyfluoroalkyl substances (PFAS) and the risk of preeclampsia and preterm birth in the United States: A Review. American Journal of Obstetrics & Gynecology MFM. DOI: 10.1016/j.ajogmf.2021.100308

Rebuli, M.E., Glista-Baker, E., Hoffman, J.R., Duffney, P.F., Robinette, C., Speen, A.M., Pawlak, E.A., Dhingra, R., Noah, T.L., Jaspers, I. (2021). Electronic-cigarette use alters nasal mucosal immune response to live-attenuated influenza virus. A clinical trialAmerican Journal of Respiratory Cell and Molecular Biology. DOI: 10.1165/rcmb.2020-0164OC

Shanahan MT, Kanke M, Oyesola OO, Hung YH, Koch-Laskowski K, Singh AP, Peck BCE, Biraud M, Sheahan B, Cortes JE, Gong H, Sahoo DK, Cubitt R, Kurpios NA, Mochel JP, Allenspach K, McElroy SJ, Ding S, von Moltke J, Dekaney CM, Tait-Wojno ED, Sethupathy P. Multiomic analysis defines the first microRNA atlas across all small intestinal epithelial lineages and reveals novel markers of almost all major cell types. Am J Physiol Gastrointest Liver Physiol. 2021 Dec 1;321(6):G668-G681. doi: 10.1152/ajpgi.00222.2021. Epub 2021 Oct 13. PubMed PMID: 34643097; PubMed Central PMCID: PMC8887887.

Zhang J, Zhou H, Liu Y, Cai J. Conditional screening for ultrahigh-dimensional survival data in case cohort studies. Lifetime Data Anal. 2021 Oct;27(4):632-661. doi: 10.1007/s10985-021-09531-7. Epub 2021 Aug 20. PubMed PMID: 34417679; PubMed Central PMCID: PMC8561435.

Zhang W, Lanzoni G, Hani H, Overi D, Cardinale V, Simpson S, Pitman W, Allen A, Yi X, Wang X, Gerber D, Prestwich G, Lozoya O, Gaudio E, Alvaro D, Tokaz D, Dominguez-Bendala J, Adin C, Piedrahita J, Mathews K, Sethupathy P, Carpino G, He Z, Wauthier E, Reid LM. Patch grafting, strategies
for transplantation of organoids into solid organs such as liver. Biomaterials. 2021 Oct;277:121067. doi: 10.1016/j.biomaterials.2021.121067. Epub 2021 Aug 25. PubMed PMID: 34517276; PubMed Central PMCID: PMC8826591.

Smith GJ, Tovar A, Kanke M, Wang Y, Deshane JS, Sethupathy P, Kelada SNP. Ozone-induced changes in the murine lung extracellular vesicle small RNA landscape. Physiol Rep. 2021 Sep;9(18):e15054. doi: 10.14814/phy2.15054. PubMed PMID: 34558223; PubMed Central PMCID: PMC8461034.

Hutch CR, Stelmak D, Kanke M, Koch-Laskowski K, Cummings B, Griffin C, Leix K, Sethupathy P, Singer K, Sandoval DA. Diet-dependent sex differences in the response to vertical sleeve gastrectomy. Am J Physiol Endocrinol Metab. 2021 Jul 1;321(1):E11-E23. doi: 10.1152/ajpendo.00060.2021. Epub 2021 May 17. PubMed PMID: 33998293; PubMed Central PMCID: PMC8321822.

Zhou Q, Cai J, Zhou H. Semiparametric regression analysis of case-cohort studies with multiple interval censored disease outcomes. Stat Med. 2021 Jun 15;40(13):3106-3123. doi: 10.1002/sim.8962. Epub 2021 Mar 29. PubMed PMID: 33783001; PubMed Central PMCID: PMC8691208.

Liu Y, Wu Y, Zhang J, Zhou H. Cox regression analysis for distorted covariates with an unknown distortion function. Biom J. 2021 Jun;63(5):968-983. doi: 10.1002/bimj.202000209. Epub 2021 Mar 9. PubMed PMID: 33687092; PubMed Central PMCID: PMC8691206.

Wang X, Zhang W, Yang Y, Wang J, Qiu H, Liao L, Oikawa T, Wauthier E, Sethupathy P, Reid LM, Liu Z, He Z. A MicroRNA-Based Network Provides Potential Predictive Signatures and Reveals the Crucial Role of PI3K/AKT Signaling for Hepatic Lineage Maturation. Front Cell Dev Biol . 2021;9:670059. doi: 10.3389/fcell.2021.670059. eCollection 2021. PubMed PMID: 34141708; PubMed Central PMCID:PMC8204022.

van der Lelie D, Oka A, Taghavi S, Umeno J, Fan TJ, Merrell KE, Watson SD, Ouellette L, Liu B, Awoniyi M, Lai Y, Chi L, Lu K, Henry CS, Sartor RB. Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis. Nat Commun. 2021 May 28;12(1):3105. doi: 10.1038/s41467-021-23460-x. PubMed PMID: 34050144; PubMed Central PMCID: PMC8163890.

O’Connor S, Murphy EA, Szwed SK, Kanke M, Marchildon F, Sethupathy P, Darnell RB, Cohen P. AGO HITS-CLIP reveals distinct miRNA regulation of white and brown adipose tissue identity. Genes Dev. 2021 May 1;35(9-10):771-781. doi: 10.1101/gad.345447.120. Epub 2021 Apr 8. PubMed PMID:
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Swahari V, Nakamura A, Hollville E, Stroud H, Simon JM, Ptacek TS, Beck MV, Flowers C, Guo J, Plestant C, Liang J, Kurtz CL, Kanke M, Hammond SM, He YW, Anton ES, Sethupathy P, Moy SS, Greenberg ME, Deshmukh M. MicroRNA-29 is an essential regulator of brain maturation through
regulation of CH methylation. Cell Rep. 2021 Apr 6;35(1):108946. doi: 10.1016/j.celrep.2021.108946. PubMed PMID: 33826889; PubMed Central PMCID: PMC8103628.

Hung YH, Huang S, Dame MK, Yu Q, Yu QC, Zeng YA, Camp JG, Spence JR, Sethupathy P. Chromatin regulatory dynamics of early human small intestinal development using a directed differentiation model. Nucleic Acids Res. 2021 Jan 25;49(2):726-744. doi: 10.1093/nar/gkaa1204. PubMed PMID: 33406262; PubMed Central PMCID: PMC7826262.

Santos Jr, H.P., Bhattacharya, A., Joseph, R.M., Smeester, L., Kuban, K.C.K., Marsit, C.J., O’Shea, T.M., Fry, R.C. (2021). Molecular Autism. DOI: 10.1186/s13229-020-00402-w

Sigmon, J.S., Blanchard, M.W., Baric, R.S., Bell, T.A., Brennan, J., Brockmann, G.A., Burks, A.W., Calabrese, J.M., Caron, K.M., Cheney, R.E., Ciavatta, D., Conlon, F., Darr, D.B., Faber, J., Franklin, C., Gershon, T.R., Gralinski, L., Gu, B., Gaines, C.H., Hagan, R.S., Heimsath, E.G., Heise, M.T., Hock, P., Ideraabdullah, F., Jennette, J.C., Kafri, T., Kashfeen, A., Kulis, M., Kumar, V., Linnertz, C., Livraghi-Butrico, A., Lloyd, K.C.K., Lutz, C., Lynch, R.M., Magnuson, T., Matsushima, G.K., McMullan, R., Miller, D.R., Mohlke, K.L., Moy, S.S., Murphy, C.E.Y., Najarian, M., O’Brien, L., Palmer, A.A., Philpot, B.D., Randell, S.H., Reinholdt, L., Ren, Y., Rockwood, S., Rogala, A.R., Saraswatula, A., Sassetti, C.M., Schisler, J.C., Schoenrock, S.A., Shaw, G.D., Shorter, J.R., Smith, C.M., St. Pierre, C.L., Tarantino, L.M., Threadgill, D.W., Valdar, W., Vilen, B.J., Wardwell, K., Whitmire, J.K., Williams, L., Zylka, M.J., Ferris, M.T., McMillan, L., Pardo-Manuel de Villena, F. (2020). Content and Performance of the MiniMUGA Genotyping Array, a New Tool To Improve Rigor and Reproducibility in Mouse Research. Genetics, 216(4), 905-930. DOI: 10.1534/genetics.120.303596

Venkatratnam, A., Douillet, C., Topping, B.C., Shi, Q., Addo, K.A., Ideraabdullah, F.Y., Fry, R.C., Stýblo, M. (2020). Sex-dependent effects of preconception exposure to arsenite on gene transcription in parental germ cells and on transcriptomic profiles and diabetic phenotype of offspring. Archives of Toxicology. DOI: 10.1007/s00204-020-02941-w

Yu, W., Hill, S.F., Xenakis, J.G., Pardo-Manuel de Villena, F., Wagnon, J.L., Meisler, M.H. (2020). Gabra2 is a genetic modifier of Scn8a encephalopathy in the mouse. Epilepsia, 61(12), 2847-2856. DOI: 10.1111/epi.16741

Lebow-Skelley, E., Yelton, S., Janssen, B., Erdei, E., Pearson, M.A. (2020). Identifying Issues and Priorities in Reporting Back Environmental Health Data. International Journal of Environmental Research and Public Health, 17(18), 6742. DOI: 10.3390/ijerph17186742

Gu, B., Shorter, J.R., Williams, L.H., Bell, T.A., Hock, P. Dalton, K.A., Pan, Y., Miller, D.R., Shaw, G.D., Philpot, B.D., Pardo-Manuel de Villena, F. (2020). Collaborative Cross mice reveal extreme epilepsy phenotypes and genetic loci for seizure susceptibility. Epilepsia, 61(9), 2010-2021. DOI: 10.1111/epi.16617

Douillet, C., Koller, B.H., Stýblo, M. (2020). Metabolism of Inorganic Arsenic in Mice Lacking Genes Encoding GST-P, GST-M, and GST-T. Chemical Research in Toxicology, 33(8), 2043-2046. DOI: 10.1021/acs.chemrestox.0c00273

Gray, K.M., LePrevost, C.E., Cope, W.G. (2020). Anglers’ Views on Using Signs to Communicate Fish Consumption Advisories. Fisheries, 45(10), 307-316. DOI: 10.1002/fsh.10463

Li, Y.Y., Douillet, C., Huang, M., Beck, R., Sumner, S.J., Stýblo, M. (2020). Exposure to inorganic arsenic and its methylated metabolites alters metabolomics profiles in INS-1 832/13 insulinoma cells and isolated pancreatic islets. Archives of Toxicology, 94(6), 1955-1972. DOI: 10.1007/s00204-020-02729-y

Eaves, LA; Nguyen, HT; Rager, JE; Sexton, KG; Howard, T; Smeester, L; Freedman, AN; Aagaard, KM; Shope, C; Lefer, B; Flynn, JH; Erickson, MH; Fry, RC; Vizuete, W. Identifying the Transcriptional Response of Cancer and Inflammation-Related Genes in Lung Cells in Relation to Ambient Air Chemical Mixtures in Houston, Texas. Environ Sci Technol. 2020 Nov 3;54(21):13807-13816. doi: 10.1021/acs.est.0c02250. Epub 2020 Oct 16. PubMed PMID: 33064461; PubMed Central PMCID: PMC7757424.

Hillis DA, Yadgary L, Weinstock GM, Pardo-Manuel de Villena F, Pomp D, Fowler AS, Xu S, Chan F, Garland T Jr. Genetic Basis of Aerobically Supported Voluntary Exercise: Results from a Selection Experiment with House Mice. Genetics. 2020 Nov;216(3):781-804. doi: 10.1534/genetics.120.303668. Epub 2020 Sep 25. PubMed PMID: 32978270; PubMed Central PMCID: PMC7648575.

Eaves LA, Phookphan P, Rager JE, Bangma J, Santos HP Jr, Smeester L, O’Shea TM, Fry RC. A role for microRNAs in the epigenetic control of sexually dimorphic gene expression in the human placenta. Epigenomics. 2020 Sep;12(17):1543-1558. doi: 10.2217/epi-2020-0062. Epub 2020 Sep 9. PubMed PMID: 32901510; PubMed Central PMCID: PMC7607407.

Payton A, Clark J, Eaves L, Santos HP Jr, Smeester L, Bangma JT, O’Shea TM, Fry RC, Rager JE. Placental genomic and epigenomic signatures associated with infant birth weight highlight mechanisms involved in collagen and growth factor signaling. Reprod Toxicol. 2020 Sep;96:221-230. doi: 10.1016/j.reprotox.2020.07.007. Epub 2020 Jul 25. PubMed PMID: 32721520; PubMed Central PMCID: PMC7855285.

Huda MN, VerHague M, Albright J, Smallwood T, Bell TA, Que E, Miller DR, Roshanravan B, Allayee H, Manuel de Villena FP, Bennett BJ. Dissecting the Genetic Architecture of Cystatin C in Diversity Outbred Mice. G3 (Bethesda). 2020 Jul 7;10(7):2529-2541. doi: 10.1534/g3.120.401275. PubMed PMID: 32467129; PubMed Central PMCID: PMC7341122.

Yu J, Zhou H, Cai J. Accelerated failure time model for data from outcome-dependent sampling. Lifetime Data Anal. 2021 Jan;27(1):15-37. doi: 10.1007/s10985-020-09508-y. Epub 2020 Oct 12. PubMed PMID: 33044612; PubMed Central PMCID: PMC7856009.

Wang T, Wang X, George SL, Zhou H. Design and analysis of biomarker-integrated clinical trials with adaptive threshold detection and flexible patient enrichment. J Biopharm Stat. 2020 Nov 1;30(6):1060-1076. doi: 10.1080/10543406.2020.1832110. Epub 2020 Nov 11. PubMed PMID: 33175640; PubMed Central PMCID: PMC7954851.

Zhang, J; Zhou, H; Liu, Y; Cai, J. (2022) Feature screening for case-cohort studies with failure time outcome. Scandinavian Journal of Statistics 2021, 48(1):349-370. DOI: 10.1111/sjos.12503. PMID: 35811582; PMCID: PMC9269537.

Director: Rebecca Fry, PhD
Deputy Director: Fernando Pardo-Manuel de Villena, PhD
Funding provided by NIEHS grant #P42 ES031007

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