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Center for Environmental Health and Susceptibility
Pilot Projects

Pilot Projects Program

The Pilot Projects Program is a high-impact and strategic activity of the Center for Environmental Health and Susceptibility (CEHS).  Its mission is to provide funds to support preliminary data collection or feasibility studies.  The data obtained through these pilot investigations are critical to the success of new proposals for external funding in environmental health. The program prioritizes support for junior investigators developing research programs in environmental health research and for interdisciplinary teams conducting translational environmental health research. The Pilot Projects Program also assists senior researchers in other areas to apply their expertise to environmental health problems.

Pilot Project applications are accepted year-round on a rolling basis, and funds are made available each April.

For 2020 Pilot Project Awards, a letter of intent must be submitted online by Dec. 20, 2019, and proposals will be due by Jan. 20, 2020.

If you are ready to apply, please review the CEHS Pilot Proposal Guidelines for detailed instructions.

Dr. Ilona Jaspers demonstrating her research

Dr. Ilona Jaspers demonstrating how inhaled pollutants impact respiratory immune responses

The Pilot Projects Program issues requests for applications for three types of awards annually:

  • Standard Pilot Projects – Traditionally, these proposals are projects submitted by a single investigator.
  • Interdisciplinary Pilot Projects – These are projects proposed by a team of interdisciplinary investigators.
  • Rapid Response Seed Projects (pending availability) – Rapid response seed funds are used to expedite research in CEHS-related research areas, small amount of money for very short term projects. Funds are intended to be used in the same year.
  • Methods Development Funding (click here for information about how to apply) – This special effort to provide resources to investigators will allow development of novel assays and methods related to health effects of environmental exposures.

Eligible primary investigators must hold a UNC faculty appointment. Applications are particularly encouraged from primary investigators at the assistant or associate level.  All applications are evaluated for likelihood of developing their pilot project into a full NIEHS grant application.


Previously Awarded Pilot Projects

Current Funding Cycle: 2016-2020

  • 2019 CEHS Pilot Projects
  • 2018 CEHS Pilot Projects
  • 2017 CEHS Pilot Projects
  • 2016 CEHS Pilot Projects
  • CEHS Pilot Project Archives

2019 CEHS Pilot Projects

Project Title: Baby teeth: A new frontier for investigating environmental risk factors for birth defects
Award Amount: $30,000
Awardee: Tania Desrosiers, Research Assistant Professor,
Department of Epidemiology, Gillings School of Global Public Health, UNC Chapel Hill

Project Title: Development of peanut allergy through airway exposure to peanut antigens in house dust
Award Amount: $30,000
Awardee: Michael Kulis, Assistant Professor,
School of Medicine, Department of Pediatrics, Division of Allergy, Immunology, and Rheumatology, UNC Chapel Hill

Project Title: Demonstrating the impact of clothing on transdermal uptake of endocrine disruptors found in home environments
Award Amount: $30,000
Awardee: Glenn Morrison, Professor,
Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, UNC Chapel Hill

Project Title: Environmental Contributors to Health Outcomes in North Carolina’s Least Healthy County
Award Amount: $50,000
Awardees: Lawrence Engel, Associate Professor, Department of Epidemiology and Jackie MacDonald, Professor,
Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, UNC Chapel Hill

Project Title: The placental exposome: a driver of epigenetic regulation and preeclampsia
Award Amount: $50,000
Awardees: Julia Rager, Assistant Professor, and Rebecca Fry, Professor, Department Environmental Sciences and Engineering, Gillings School of Global Public Health, UNC Chapel Hill, and
Kim Boggess, Professor, and Tracy Manuck, Professor, Department of Obstetrics and Gynecology, UNC-Chapel Hill

2018 CEHS Pilot Projects

Project Title: Susceptibility to Arsenic-Induced Diabetes: The Role of As3mt Polymorphisms and the Microbiome

Award Amount: $50,000
Awardee: Miroslav Styblo, PhD, Professor, Department of Nutrition, and Adjunct Associate Professor, Department of Environmental Sciences and Engineering, UNC Gillings School of Global Public Health (Faculty Profile)
Relevant Publication(s):
1. Beck RF, Bommarito P, Douillet C, Kanke M, Del Razo LM, Garcia-Vargas G, Fry RC, Sethupathy P, Styblo M. Circulating miRNAs associated with arsenic exposure. Environmental science & technology. 2018 Nov 20.

Project Title: Defining Novel Chk2 Functions in Suppression of UV-induced Skin Carcinogenesis
Award Amount: $25,000
Awardee: Di Wu, PhD, Assistant Professor, Department of Biostatistics, UNC Gillings School of Global Public Health (Faculty Profile)
Relevant Publication(s):
1. Tanoue Y, Toyoda T, Sun J, Mustofa MK, Tateishi C, Endo S, Motoyama N, Araki K, Wu D, Okuno Y, Tsukamoto T, Takeya M, Ihn H, Vaziri C, Tateishi S. Differential Roles of Rad18 and Chk2 in Genome Maintenance and Skin Carcinogenesis Following UV Exposure. The Journal of investigative dermatology. 2018 Dec;138(12):2550-7.

Project Title: Feasibility of Measuring Environmental Toxicants and Endogenous Markers of Possible Immunotoxicity from Newborn Blood Spots to Study Risk Factors for Eosinophilic Esophagitis
Award Amount: $12,000
Awardee: Evan Dellon, PhD, Associate Professor of Medicine, Adjunct Associate Professor of Epidemiology, UNC School of Medicine (Faculty Profile)
Relevant Publication(s):
1. Jensen ET, Dellon ES. Environmental factors and eosinophilic esophagitis. The Journal of allergy and clinical immunology. 2018 Jul;142(1):32-40. PMCID: PMC6035771.

Project Title: Genomic Influences on Ozone Response in Mice
Award Amount: $50,000
Awardee: Terrence Furey, PhD, Associate Professor, Department of Genetics, University of North Carolina
(Faculty Profile)

Project Title: Identification of Indoor Environmental Adjuvants in House Dust
Award Amount: $25,000
Awardee: Timothy Moran, MD, PhD, Assistant Professor of Pediatrics, Pediatric Allergy and Immunology, University of North Carolina (Faculty Profile)

Project Title: Does Prenatal Pesticide Exposure Exacerbate Phenotypes in a Mouse Model of Autism?
Award Amount: $25,000
Awardee: Mark J. Zylka, PhD, W.R. Kenan, Jr. Distinguished Professor, Department of Cell Biology and Physiology, UNC School of Medicine (Faculty Profile)

Project Title: The Spatial Distribution of Lead Exposure: Identifying Social and Neighborhood Factors Associated with Blood Lead Concentration in Durham and Detroit
Award Amount:  $12,000
Awardee: Allison Aiello, PhD, Professor, Department of Epidemiology, UNC Gillings School of Global Public Health (Faculty Profile)

Project Title: Sampling the Nasal Epithelial Lining Fluid as a Non-Invasive Indicator of Pollutant-Induced Modification of COPD
Award Amount: $10,100
Awardee: Ilona Jaspers, PhD, Professor, Department of Environmental Sciences and Engineering, and Department of Pediatrics, Microbiology, and Immunology, UNC Gillings School of Global Public Health (Faculty Profile)

Project Title: Pro-Inflammatory Responses of Airway Cells to Hydroperoxyalkenyls, Emerging Toxic Components of PM2.5
Award Amount: $9,000
Awardee: Avram Gold, PhD, Professor and Associate Chair for Academics, Department of Environmental Sciences and Engineering, UNC Gillings School of Global Public Health (Faculty Profile)

Project Title: Glycine Cleavage System (GCS) Formaldehyde Induced Genotoxicity
Award Amount: $12,000
Awardee: Jeffrey MacDonald, PhD, Associate Professor, Joint Department of Biomedical Engineering at UNC and NC State (Faculty Profile)

Project Title: Connection of Vibrio Bacterial Dynamics to Exposure After Extreme Events
Award Amount: $13,500
Awardee: Rachel Noble, PhD, Mary and Watts Hill Jr. Distinguished Professor, Department of Environmental Sciences and Engineering and Department of Marine Sciences, University of North Carolina (Faculty Profile)

Project Title: Cadmium Exposure and Hepatocellular Carcinoma
Award Amount: $25,000
Awardee: Cathrine Hoyo, PhD, Director, Epidemiology and Environmental Epigenomics Laboratory, and Associate Professor, Department of Biological Sciences, NC State University (Faculty Profile)

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2017 CEHS Pilot Projects

Project Title: Exploring a causal among toxic metals and hypertension using genomics
Award Amount: $30,000, Award Type: Standard Pilot Project
Awardee: Nora Franceschini, MD, MPH, Research Associate Professor, Department of Epidemiology (Faculty Profile)
Relevant Publications:
1. Oliver-Williams C, Howard AG, Navas-Acien A, Howard BV, Tellez-Plaza M, Franceschini N. Cadmium body burden, hypertension, and changes in blood pressure over time: results from a prospective cohort study in American Indians. Journal of the American Society of Hypertension : JASH. 2018 Jun;12(6):426-37.e9. PMCID: PMC5972063.

Project Title: Development of a structural-functional optical imaging platform for environmental exposure studies in an organotypic model of the mammary gland
Award Amount: $30,000, Award Type: Standard Pilot Project
Awardee: Amy L. Oldenburg, Associate Professor, Department of Physics and Astronomy (Primary). Also affiliated with: Biomedical Research Imaging Center, Department of Biomedical Engineering and Lineberger Comprehensive Cancer Center (Faculty Profile)
Relevant Publications:
1. Yu X, Fuller AM, Blackmon R, Troester MA, Oldenburg AL. Quantification of the Effect of Toxicants on the Intracellular Kinetic Energy and Cross-Sectional Area of Mammary Epithelial Organoids by OCT Fluctuation Spectroscopy. Toxicological sciences : an official journal of the Society of Toxicology. 2018 Mar 1;162(1):234-40. PMCID: PMC6059173. (Candidate Pub: PP 2017 Award) JTB(sel)Jan.2018

Project Title: Airway Extracellular Vesicle MicroRNA Profiling in Ozone-Induced Asthma
Award Amount: $30,000, Award Type: Standard Pilot Project
Awardee: Gregory J. Smith, Ph.D. and Samir Kelada, Ph.D., M.P.H., Department of Genetics (Faculty Profile)

Project Title: Use of isotopic ratios to characterize newborn blood lead measures and environmental lead contamination from operating industrial sites in Forsyth County, North Carolina
Award Amount: $30,000, Award Type: Standard Pilot Project
Awardee: David Richardson, PhD, Associate Professor, Epidemiology Department (Faculty Profile)

Project Title: Identifying the Effects of Environmental Toxicant Exposure on miRNA-regulated Adrenomedullin in the Development of Preeclampsia
Award Amount: $30,000, Award Type: Standard Pilot Project
Awardee: Kathleen M. Caron, Professor and Chair of the Department of Cell Biology and Physiology (Faculty Profile)

Project Title: Alleviating Environmental Toxin Damage via the Gut Microbiota.
Award Amount: $50,000, Award Type: Interdisciplinary Pilot Project
Awardees:
1. Matthew R. Redinbo, Kenan Distinguished Professor, Department of Chemistry, College of Arts & Sciences, and Biochemistry, Microbiology, Genomics, School of Medicine (Faculty Profile)
2. Kun Lu, Assistant Professor, Department of Environmental Sciences and Engineering (Faculty Profile)
3. Scott Bultman, Associate Professor, Department of Genetics (Faculty Profile)
Relevant Publications:
1. Yauw STK, Arron M, Lomme R, van den Broek P, Greupink R, Bhatt AP, Redinbo MR, van Goor H. Microbial Glucuronidase Inhibition Reduces Severity of Diclofenac-Induced Anastomotic Leak in Rats. Surgical infections. 2018 May/Jun;19(4):417-23. PMCID: PMC5961743. .Multi
2. Pellock SJ, Creekmore BC, Walton WG, Mehta N, Biernat KA, Cesmat AP, Ariyarathna Y, Dunn ZD, Li B, Jin J, James LI, Redinbo MR. Gut Microbial beta-Glucuronidase Inhibition via Catalytic Cycle Interception. ACS central science. 2018 Jul 25;4(7):868-79. PMCID: PMC6062831. .Multi IHSFC(sel)
3. Yu AM, Ingelman-Sundberg M, Cherrington NJ, Aleksunes LM, Zanger UM, Xie W, Jeong H, Morgan ET, Turnbaugh PJ, Klaassen CD, Bhatt AP, Redinbo MR, Hao P, Waxman DJ, Wang L, Zhong XB. Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO). Acta pharmaceutica Sinica B. 2017 Mar;7(2):241-8. PMCID: PMC5343155. (Candidate Pub: PP 2017 Award)
4. Bhatt AP, Redinbo MR, Bultman SJ. The role of the microbiome in cancer development and therapy. CA: a cancer journal for clinicians. 2017 Jul 08;67(4):326-44. PMCID: PMC5530583. (Candidate Pub: PP 2017 Award)

Project Title: Environmental Impacts on early Brain Development.
Award Amount: $50,000, Award Type: Interdisciplinary Pilot Project
Awardees:
1. Stephanie M. Engel, PhD, Associate Professor of Epidemiology (Faculty Profile)
2. Weili Lin, PhD, Professor of Radiology, Neurology and Biomedical Engineering, Director of BRIC (Faculty Profile)
3. Joseph Piven, MD, Professor of Psychiatry, Pediatrics and Psychology, Director of CIDD (Faculty Profile)
4. Margaret Sheridan, PhD, Assistant Professor of Clinical Psychology (Faculty Profile)
5. John H. Gilmore, MD Distinguished Professor, Director of the Early Brain Development Program (Faculty Profile)
Relevant Publications:
1. Doherty BT, Hoffman K, Keil AP, Engel SM, Stapleton HM, Goldman BD, Olshan AF, Daniels JL. Prenatal exposure to organophosphate esters and cognitive development in young children in the Pregnancy, Infection, and Nutrition Study. Environmental research. 2018 Oct 30;169:33-40. DD DD DD
2. Singer AB, Wolff MS, Silva MJ, Calafat AM, Engel SM. Prenatal phthalate exposures and child temperament at 12 and 24 months. Neurotoxicology. 2017 Sep;62:248-57. PMCID: PMC5623642. (Candidate Pub: PP 2017 Award)
3. Furlong MA, Herring A, Buckley JP, Goldman BD, Daniels JL, Engel LS, Wolff MS, Chen J, Wetmur J, Barr DB, Engel SM. Prenatal exposure to organophosphorus pesticides and childhood neurodevelopmental phenotypes. Environmental research. 2017 Oct;158:737-47. PMCID: PMC5577985. (Candidate Pub: PP 2017 Award)
4. Furlong MA, Barr DB, Wolff MS, Engel SM. Prenatal exposure to pyrethroid pesticides and childhood behavior and executive functioning. Neurotoxicology. 2017 Sep;62:231-8. PMCID: PMC5623638. (Candidate Pub: PP 2017 Award)

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2016 CEHS Pilot Projects

Project Title: Interaction between infectious disease and environmental exposure.
Award Amount: $30,000, Award Type: Standard Pilot Project
Awardees: Kun Lu, PhD, Assistant Professor, and Zhenfa Zhang, PhD, Research Assistant Professor, UNC Department of Department of Environmental Sciences and Engineering
Relevant Publications:
1. Liu CW, Chi L, Tu P, Xue J, Ru H, Lu K. Isobaric Labeling Quantitative Metaproteomics for the Study of Gut Microbiome Response to Arsenic. Journal of proteome research. Epub 2018 Dec 14.
2. Chi L, Xue J, Tu P, Lai Y, Ru H, Lu K. Gut microbiome disruption altered the biotransformation and liver toxicity of arsenic in mice. Archives of toxicology. Epub 2018 Oct 24.
3. Wu F, Chi L, Ru H, Parvez F, Slavkovich V, Eunus M, Ahmed A, Islam T, Rakibuz-Zaman M, Hasan R, Sarwar G, Graziano JH, Ahsan H, Lu K, Chen Y. Arsenic Exposure from Drinking Water and Urinary Metabolomics: Associations and Long-Term Reproducibility in Bangladesh Adults. Environmental health perspectives. 2018 Jan 12;126(1):017005. PMCID: PMC6014710.
4. Chi L, Gao B, Tu P, Liu CW, Xue J, Lai Y, Ru H, Lu K. Individual susceptibility to arsenic-induced diseases: the role of host genetics, nutritional status, and the gut microbiome. Mammalian genome : official journal of the International Mammalian Genome Society. 2018 Feb;29(1-2):63-79. PMCID: PMC6191311.
5. Gao B, Tu P, Bian X, Chi L, Ru H, Lu K. Profound perturbation induced by triclosan exposure in mouse gut microbiome: a less resilient microbial community with elevated antibiotic and metal resistomes. BMC pharmacology & toxicology. 2017 Jun 12;18(1):46. PMCID: PMC5469155.
6. Chi L, Bian X, Gao B, Tu P, Ru H, Lu K. The Effects of an Environmentally Relevant Level of Arsenic on the Gut Microbiome and Its Functional Metagenome. Toxicological sciences : an official journal of the Society of Toxicology. 2017 Dec 1;160(2):193-204. PMCID: PMC5837326.
7. Bian X, Tu P, Chi L, Gao B, Ru H, Lu K. Saccharin induced liver inflammation in mice by altering the gut microbiota and its metabolic functions. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2017 Sep;107(Pt B):530-9. PMCID: PMC5647777
8. Bian X, Chi L, Gao B, Tu P, Ru H, Lu K. Gut Microbiome Response to Sucralose and Its Potential Role in Inducing Liver Inflammation in Mice. Frontiers in physiology. 2017 8:487. PMCID: PMC5522834.

Project Title: Chemical Mechanism of Ozone-Induced   DNA Damage.
Award Amount: $30,000, Award Type: Standard Pilot Project
Awardee: Zhenfa Zhang, PhD, Research Assistant Professor, UNC Department of Environmental Science and Engineering
Project Title: Impact of common African American SULT polymorphisms on disease risk secondary to environmental exposures.
Award Amount: $30,000, Award Type: Standard Pilot Project
Awardee: Beverly Koller, PhD, Associate Professor, UNC Department of Genetics (Faculty Profile)

Project Title: Using CRISPR/Cas9 Technology to Establish the Role of NRF2 as a Driver of Isoprene SOA-Induced Genomic Stress Response.
Award Amount: $30,000, Award Type: Standard Pilot Project
Awardees: Rebecca Fry, PhD and Co-PIs: Jason D. Surratt, PhD and William Vizuete, PhD, UNC Department Environmental Sciences & Engineering
Relevant Publications:
1. Cui T, Zeng Z, Dos Santos EO, Zhang Z, Chen Y, Zhang Y, Rose CA, Budisulistiorini SH, Collins LB, Bodnar WM, de Souza RAF, Martin ST, Machado CMD, Turpin BJ, Gold A, Ault AP, Surratt JD. Development of a hydrophilic interaction liquid chromatography (HILIC) method for the chemical characterization of water-soluble isoprene epoxydiol (IEPOX)-derived secondary organic aerosol. Environmental science Processes & impacts. 2018 Nov 14;20(11):1524-36.
2. Bondy AL, Craig RL, Zhang Z, Gold A, Surratt JD, Ault AP. Isoprene-Derived Organosulfates: Vibrational Mode Analysis by Raman Spectroscopy, Acidity-Dependent Spectral Modes, and Observation in Individual Atmospheric Particles. The journal of physical chemistry A. 2018 Jan 11;122(1):303-15.
3. Arashiro M, Lin YH, Zhang Z, Sexton KG, Gold A, Jaspers I, Fry RC, Surratt JD. Effect of secondary organic aerosol from isoprene-derived hydroxyhydroperoxides on the expression of oxidative stress response genes in human bronchial epithelial cells. Environmental science Processes & impacts. 2018 Feb 21;20(2):332-9.
4. Lin YH, Arashiro M, Clapp PW, Cui T, Sexton KG, Vizuete W, Gold A, Jaspers I, Fry RC, Surratt JD. Gene Expression Profiling in Human Lung Cells Exposed to Isoprene-Derived Secondary Organic Aerosol. Environmental science & technology. 2017 Jul 18;51(14):8166-75. PMCID: PMC5610912.
5. Riva M, Budisulistiorini SH, Chen Y, Zhang Z, D’Ambro EL, Zhang X, Gold A, Turpin BJ, Thornton JA, Canagaratna MR, Surratt JD. Chemical Characterization of Secondary Organic Aerosol from Oxidation of Isoprene Hydroxyhydroperoxides. Environmental science & technology. 2016 Sep 20;50(18):9889-99.
6. Liu J, D’Ambro EL, Lee BH, Lopez-Hilfiker FD, Zaveri RA, Rivera-Rios JC, Keutsch FN, Iyer S, Kurten T, Zhang Z, Gold A, Surratt JD, Shilling JE, Thornton JA. Efficient Isoprene Secondary Organic Aerosol Formation from a Non-IEPOX Pathway. Environmental science & technology. 2016 Sep 20;50(18):9872-80.

Project Title: Defining MAGEA4-RAD18 as a Novel Mutagenic Driver of Environmental Carcinogenesis.
Award Amount: $50,000, Award Type: Interdisciplinary Pilot Project
Awardees: Cyrus Vaziri, PhD and Scott Williams, PhD, Department of Pathology and Laboratory Medicine, UNC School of Medicine; Di Wu, PhD, Department of Periodontology, UNC School of Dentistry
Relevant Publications:
1. Yang Y, Gao Y, Zlatanou A, Tateishi S, Yurchenko V, Rogozin IB, Vaziri C. Diverse roles of RAD18 and Y-family DNA polymerases in tumorigenesis. Cell cycle (Georgetown, Tex). 2018 May 8;17(7):833-43. PMCID: PMC6056224.
2. Tanoue Y, Toyoda T, Sun J, Mustofa MK, Tateishi C, Endo S, Motoyama N, Araki K, Wu D, Okuno Y, Tsukamoto T, Takeya M, Ihn H, Vaziri C, Tateishi S. Differential Roles of Rad18 and Chk2 in Genome Maintenance and Skin Carcinogenesis Following UV Exposure. The Journal of investigative dermatology. 2018 Dec;138(12):2550-7.
3. Yang Y, Gao Y, Mutter-Rottmayer L, Zlatanou A, Durando M, Ding W, Wyatt D, Ramsden D, Tanoue Y, Tateishi S, Vaziri C. DNA repair factor RAD18 and DNA polymerase Polkappa confer tolerance of oncogenic DNA replication stress. The Journal of cell biology. 2017 Oct 02;216(10):3097-115. PMCID: PMC5626543.
4. Mutter-Rottmayer E, Gao Y, Vaziri C. Cancer cells activate damage-tolerant and error-prone DNA synthesis. Molecular & cellular oncology. 2016 3(6):e1225547. PMCID: PMC5160398.
5. Gao Y, Mutter-Rottmayer E, Greenwalt AM, Goldfarb D, Yan F, Yang Y, Martinez-Chacin RC, Pearce KH, Tateishi S, Major MB, Vaziri C. A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis. Nature communications. 2016 Jul 05;7:12105. PMCID: PMC4935975.

Project Title: Non-Invasive Sampling Techniques To Assess Potential Health Disparities In Environmental Triggers Of Asthma.
Award Amount: $50,000, Award Type: Interdisciplinary Pilot Project
Awardees: Ilona Jaspers, PhD, Michelle Hernandez , PhD, and Allison Burbank, PhD, Department of Pediatrics, UNC School of Medicine
Relevant Publications:
1. Hernandez ML, Dhingra R, Burbank AJ, Todorich K, Loughlin CE, Frye M, Duncan K, Robinette C, Mills K, Devlin RB, Peden DB, Diaz-Sanchez D. Low-level ozone has both respiratory and systemic effects in African American adolescents with asthma despite asthma controller therapy. The Journal of allergy and clinical immunology. 2018 Dec;142(6):1974-7.e3. PMCID: PMC6289884.
2. Carson JL, Hernandez M, Jaspers I, Mills K, Brighton L, Zhou H, Zhang J, Hazucha MJ. Interleukin-13 stimulates production of nitric oxide in cultured human nasal epithelium. In vitro cellular & developmental biology Animal. 2018 Mar;54(3):200-4.
3. Burbank AJ, Todoric K, Steele P, Rosen J, Zhou H, Frye M, Loughlin CE, Ivins S, Mills K, Massey LD, Reeve BB, Hernandez ML. Age and African-American race impact the validity and reliability of the asthma control test in persistent asthmatics. Respiratory research. 2018 Aug 15;19(1):152. PMCID: PMC6094875.
4. Burbank AJ, Peden DB. Assessing the impact of air pollution on childhood asthma morbidity: how, when, and what to do. Current opinion in allergy and clinical immunology. 2018 Apr;18(2):124-31. PMCID: PMC6016370.
5. Rebuli ME, Speen AM, Clapp PW, Jaspers I. Novel applications for a noninvasive sampling method of the nasal mucosa. American journal of physiology Lung cellular and molecular physiology. 2017 Feb 1;312(2):L288-l96. PMCID: PMC5336583.
6. Burbank AJ, Sood AK, Kesic MJ, Peden DB, Hernandez ML. Environmental determinants of allergy and asthma in early life. The Journal of allergy and clinical immunology. 2017 Jul;140(1):1-12. PMCID: PMC5675123.
7. Burbank AJ, Duran CG, Almond M, Wells H, Jenkins S, Jiang Q, Yang C, Wang T, Zhou H, Hernandez ML, Peden DB. A short course of gamma-tocopherol mitigates LPS-induced inflammatory responses in humans ex vivo. The Journal of allergy and clinical immunology. 2017 Oct;140(4):1179-81.e4. PMCID: PMC5632577.
8. Burbank AJ, Grabich SC, Todorich K, Frye M, Loughlin C, Duncan K, Robinette C, Mills K, Peden DB, Diaz-Sanchez D, Hernandez ML. Effect of aeroallergen sensitization on asthma control in African American teens with persistent asthma. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2016 Oct;117(4):442-4.

Project Title: Etiologic heterogeneity of bladder cancer: Defining the molecular profile of low- grade, non-muscle invasive tumors.
Award Amount: $50,000, Award Type: Interdisciplinary Pilot Project
Awardees: Andrew Olshan, PhD, Professor and Chair, Department of Epidemiology, UNC Gillings School of Global Public Health; William Kim, PhD, UNC Department of Medicine, and Katherine Hoadley, PhD, UNC Department of Genetics, School of Medicine
Relevant Publications:
1. Saito R, Smith CC, Utsumi T, Bixby LM, Kardos J, Wobker SE, Stewart KG, Chai S, Manocha U, Byrd KM, Damrauer JS, Williams SE, Vincent BG, Kim WY. Molecular Subtype-Specific Immunocompetent Models of High-Grade Urothelial Carcinoma Reveal Differential Neoantigen Expression and Response to Immunotherapy. Cancer research. 2018 Jul 15;78(14):3954-68. PMCID: PMC6157276.
2. Tilley SK, Kim WY, Fry RC. Analysis of bladder cancer tumor CpG methylation and gene expression within The Cancer Genome Atlas identifies GRIA1 as a prognostic biomarker for basal-like bladder cancer. American journal of cancer research. 2017 7(9):1850-62. PMCID: PMC5622220.
3. Sun X, Hoadley KA, Kim WY, Furberg H, Olshan AF, Troester MA. Age at diagnosis, obesity, smoking, and molecular subtypes in muscle-invasive bladder cancer. Cancer causes & control : CCC. 2017 Jun;28(6):539-44. PMCID: PMC5477976.
4. Seiler R, Ashab HAD, Erho N, van Rhijn BWG, Winters B, Douglas J, Van Kessel KE, Fransen van de Putte EE, Sommerlad M, Wang NQ, Choeurng V, Gibb EA, Palmer-Aronsten B, Lam LL, Buerki C, Davicioni E, Sjodahl G, Kardos J, Hoadley KA, Lerner SP, McConkey DJ, Choi W, Kim WY, Kiss B, Thalmann GN, Todenhofer T, Crabb SJ, North S, Zwarthoff EC, Boormans JL, Wright J, Dall’Era M, van der Heijden MS, Black PC. Impact of Molecular Subtypes in Muscle-invasive Bladder Cancer on Predicting Response and Survival after Neoadjuvant Chemotherapy. European urology. 2017 Oct;72(4):544-54.
5. Robertson AG, Kim J, Al-Ahmadie H, Bellmunt J, Guo G, Cherniack AD, Hinoue T, Laird PW, Hoadley KA, Akbani R, Castro MAA, Gibb EA, Kanchi RS, Gordenin DA, Shukla SA, Sanchez-Vega F, Hansel DE, Czerniak BA, Reuter VE, Su X, de Sa Carvalho B, Chagas VS, Mungall KL, Sadeghi S, Pedamallu CS, Lu Y, Klimczak LJ, Zhang J, Choo C, Ojesina AI, Bullman S, Leraas KM, Lichtenberg TM, Wu CJ, Schultz N, Getz G, Meyerson M, Mills GB, McConkey DJ, Weinstein JN, Kwiatkowski DJ, Lerner SP. Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer. Cell. 2017 Oct 19;171(3):540-56.e25. PMCID: PMC5687509.
6. Choi W, Ochoa A, McConkey DJ, Aine M, Hoglund M, Kim WY, Real FX, Kiltie AE, Milsom I, Dyrskjot L, Lerner SP. Genetic Alterations in the Molecular Subtypes of Bladder Cancer: Illustration in the Cancer Genome Atlas Dataset. European urology. 2017 Sep;72(3):354-65. PMCID: PMC5764190.

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CEHS Pilot Project Archives

  • 2014 CEHS Pilot Projects
  • 2013 CEHS Pilot Projects
  • 2012 CEHS Pilot Projects
  • 2011 CEHS Pilot Projects
  • 2010 CEHS Pilot Projects
  • 2009 CEHS Pilot Projects
  • 2008 CEHS Pilot Projects
  • 2007 CEHS Pilot Projects
  • 2006 CEHS Pilot Projects
  • 2005 CEHS Pilot Projects
  • 2004 CEHS Pilot Projects
  • 2003 CEHS Pilot Projects
  • 2002 CEHS Pilot Projects
  • 2001 CEHS Pilot Projects

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