Kun Lu, PhD
The overarching goal of Dr. Lu’s lab is to better understand health effects of environmental exposure and individual response by integrating the microbiome, exposome, omics profiling, and biomarker development. Dr. Lu’s lab is working on a number of important environmental chemicals ranging from heavy metals to pesticides, as well as others with significant public health concerns.
The current emphasis is being placed on microbiome research and exposome mapping. Dr. Lu’s lab aims at answering how gut microbiome interacts with environmental exposure, how gut microbiome affects disease susceptibility, and how host factors crosstalk with microbiome to influence its response. Another focus of Dr. Lu’s lab is to map exposome for human disease, with the goals of characterizing all exposures over the lifespan via high-resolution mass spectrometry, understanding the health impact of the exposome, and designing strategies to reduce exposure-associated adverse effects.
Dr. Lu’s lab combines both systems-level and targeted approaches in research. In particular, Dr. Lu’s lab utilizes highly integrated system-level approaches including DNA sequencing, metabolomics, proteomics and lipidomics, coupled with the application of diverse cell, animal and disease models to interrogate the pathogenesis of human disease.
Omics profiling (metabolomics, proteomics, lipidomics)