Karine Dubé, DrPH

About

Honors and Awards

R01 Grant Funding: Investigating Psychosocial Experiences of HIV Cure Trial Participants Undergoing Extended HIV Treatment Interruptions: Implications for Ethical Conduct
2021-2026, National Institute of Mental Health (NIMH)

Ethics Administrative Supplement to R21-MH118120: Advancing Empirical Research Ethics for HIV Cure Research
2020, National Institute of Mental Health

R21 Grant Funding: Perceptions of Risks and Benefits of Participating in HIV Cure-Related Research among Diverse Youth and Young Adults Living with HIV in the United States
2020, National Institute of Mental Health (NIMH)

R21 Grant Funding: Pilot Integration of Participant-Centered Outcomes in HIV Cure Research in the United States: Implications for Ethical Conduct
2019, National Institute of Mental Health (NIMH)

Arthur B. Holzworth Endowed Scholarship in Health Leadership
2015, University of North Carolina at Chapel Hill

Representative Courses

Global Health Ethics for Global Health Concentration (PUBH 710) | Syllabus

Critical Issues in Global Health (PUBH 711) | Syllabus

The AIDS Course- Online (PUBH 725) | Syllabus

Research Activities

- HIV
- Infectious Diseases
- Interdisciplinary Research

Key Publications

Participant experiences using novel home-based blood collection device for viral load testing in HIV cure trials with analytical treatment interruptions. Karine Dubé, Harsh Agarwal, William B. Carter, Lynda Dee, Jeff Taylor, Christopher Roebuck, Beth Peterson, Hursch Patel, Samuel Ndukwe, Kenneth M. Lynn, Linden Lalley-Chareczko, Emily Hiserodt, Sukyung Kim, Daniel Rosenbloom, Brad R. Evans, Melanie Anderson, Daria J. Hazuda, Kevin Bateman, Bonnie J. Howell, Livio Azzoni, Karam Mounzer, Pablo Tebas & Luis J. Montaner (2022). HIV Research & Clinical Practice, 23(1).
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"I would absolutely need to know that my partner is still going to be protected": Perceptions of HIV Cure-Related Research among Diverse HIV Serodifferent Couples in the United States. Dube K, Agarwal H, Stockman JK, Auerbach JD, Sauceda JA, Conroy A, Johnson M. (2022). AIDS Res Hum Retroviruses.
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Exploration of a Mobile Technology Vulnerability Scale's association with antiretroviral adherence among young adults living with HIV in the United States. Saberi P, Eskaf S, Campbell CK, Neilands TB, Sauceda JA, Dubé K (2022). Mhealth, 8(23).
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"I know that I was a part of making a difference": Participant motivations for joining a cure-directed HIV trial with an analytical treatment interruption. Neergaard R, Jones NL, Roebuck C, Rendle KA, Barbati Z, Peterson B, Tebas P, Mounzer K, Metzger D, Montaner LJ, Dube K, Barg FK. (2022). AIDS Res Hum Retroviruses.
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It's Time to Embed Health-related Quality of Life across all Steps of the HIV Care Cascade. Arora AK, Lessard D, Dubé K, Lebouché B. (2022). J Acquir Immune Defic Syndr.
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Community HIV clinicians' perceptions about HIV cure-related research in the Northwestern United States. Sylla L, Patel H, Louella M, Simoni J, Dubé K. (2022). HIV Res Clin Pract..
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"It comes altogether as one:" perceptions of analytical treatment interruptions and partner protections among racial, ethnic, sex and gender diverse HIV serodifferent couples in the United States. Campbell DM, Dubé K, Cowlings PD, Dionicio P, Tam RM, Agarwal H, Stockman JK, Auerbach JD, Sauceda JA, Conroy AA, Johnson MO. (2022). BMC Public Health.
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Willingness of Older Canadians with HIV to Participate in HIV Cure Research Near and After the End of Life: A Mixed-Method Study. Lessard D, Dubé K, Bilodeau M, Keeler P, Margolese S, Rosenes R, Sinyavskaya L, Durand M, Benko E, Kovacs C, Guerlotté C, Tharao W, Arnold K, Masching R, Taylor D, Sousa J, Ostrowski M, Taylor J, Kaytes A, Smith D, Gianella S, Chomont N, Angel JB, Routy JP, Cohen ÉA, Lebouché B, Costiniuk CT.  (2022). AIDS Res Hum Retroviruses..
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Ethical and practical considerations for cell and gene therapy toward an HIV cure: findings from a qualitative in-depth interview study in the United States. Dubé K, Kanazawa J, Patel H, Louella M, Sylla L, Sheehy J, Dee L, Taylor J, Adair J, Anthony-Gonda K, Dropulić B, Sauceda JA, Peluso MJ, Deeks SG, Simoni J. (2022). BMC Med Ethics.
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Participant Perspectives and Experiences Following an Intensively Monitored Antiretroviral Pause in the United States: Results from the AIDS Clinical Trials Group A5345 Biomarker Study. Dubé K, Eskaf S, Barr L, Palm D, Hogg E, Simoni JM, Sugarman J, Brown B, Sauceda JA, Henley L, Deeks S, Fox L, Gandhi RT, Smith D, Li JZ. (2022). AIDS Res Hum Retroviruses.
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"We are looking at the future right now": community acceptability of a home-based viral load test device in the context of HIV cure-related research with analytical treatment interruptions in the United States. Dubé K, Kanazawa J, Roebuck C, Johnson S, Carter WB, Dee L, Peterson B, Lynn KM, Lalley-Chareczko L, Hiserodt E, Kim S, Rosenbloom D, Evans BR, Anderson M, Hazuda DJ, Shipley L, Bateman K, Howell BJ, Mounzer K, Tebas P, Montaner LJ. (2022). HIV Res Clin Pract..
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Lessons Learned from the Last Gift Study: Ethical and Practical Challenges Faced while Conducting HIV Cure-Related Research at the End of Life. Kanazawa J, Rawlings SA, Hendrickx S, Gianella S, Concha-Garcia S, Taylor J, Kaytes A, Patel H, Ndukwe S, Little SJ, Smith D, Dubé K (2022). Journal of Medical Ethics.
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Preliminary Acceptability of a Home-Based Peripheral Blood Collection Device for Viral Load Testing in the Context of Analytical Treatment Interruptions in HIV Cure Trials: Results from a Nationwide Survey in the United States. Dubé, K., Eskaf, S., Hastie, E., Agarwal, H., Henley, L., Roebuck, C., Carter, W. B., Dee, L., Taylor, J., Mapp, D., Campbell, D. M., Villa, T. J., Peterson, B., Lynn, K. M., Lalley-Chareczko, L., Hiserodt, E., Kim, S., Rosenbloom, D., Evans, B. R., Anderson, M., Montaner, L. J (2022). Journal of personalized medicine, 12(2), 231.
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Editorial: Critical social and behavioral sciences perspectives on ending the HIV epidemic. Auerbach, J. D., & Dubé, K (2022). Current opinion in HIV and AIDS, 17(2), 37-39.
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Bringing social context into global biomedical HIV cure-related research: An urgent call to action. Miall, A., McLellan, R., Dong, K., Ndung'u, T., Saberi, P., Sauceda, J. A., & Dubé, K (2021). Journal of virus eradication, 8(1), 100062.
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Ethics of HIV Cure Research: An Unfinished Agenda. K. Dubé, J. Kanazawa, J. Taylor, L. Dee, N. Jones, C. Roebuck, L. Sylla, M. Louella, J. Kosmyna, D. Kelly, O. Clanton, D. Palm, D. M. Campbell, M. G. Onaiwu, H. Patel, S. Ndukwe, L. Henley, M. O. Johnson, P. Saberi, B. Brown, J.A. Sauceda, J. Sugarman (2021). BMC Medical Ethics, 22(1), 83.
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Ethical and Practical Considerations for Interventional HIV Cure-Related Research at the End-of-Life: A Qualitative Study with Key Stakeholders in the United States. J. Kanazawa, S. Gianella, S. Concha-Garcia, J. Taylor, A. Kaytes, C. Christensen, H. Patel, S. Ndukwe, S. Rawlings, S. Hendricks, S. Little, B. Brown, D. Smith, K. Dubé (2021). PLoS One, 16(7), e0254148.
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Considerations for Designing and Implementing Combination HIV Cure Trials: Findings from a Qualitative In-Depth Interview Study in the United States. K. Dubé, J. Kanazawa, L. Dee, J. Taylor, J.A. Sauceda, S. Gianella, D. Smith, S.G. Deeks, M.J. Peluso AIDS Research and Therapy, 18(1), 65.
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Considerations for Increasing Racial, Ethnic, Gender and Sexual Diversity in HIV Cure-Related Research with Analytical Treatment Interruptions: A Qualitative Inquiry. Dubé K, Kanazawa JT, Campbell C, Boone CA, Maragh-Bass AC, Campbell DM, Agosto-Rosario M, Stockman JK, Diallo DD, Poteat T, Johnson M, Saberi P, Sauceda JA (2021). AIDS Research Human Retroviruses.
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SARS-CoV-2 vaccination in the context of ongoing HIV cure-related research studies. Peluso MJ, Dee L, Taylor J, Campbell DM, Ehm A, Agosto-Rosario M, Shao S, Williams MC, Hoh R, Rutishauser RL, Deeks SG, Sauceda JA, Dubé K (2021). Journal of Acquired Immune Deficiency Syndromes.
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Ethical and practical considerations for mitigating risks to sexual partners during analytical treatment interruptions in HIV cure-related research. Dubé K, Kanazawa J, Dee L, Taylor J, Campbell DM, Brown B, Johnson MO, Saberi P, Sauceda JA, Sugarman J, Peluso MJ (2021). HIV Research & Clinical Practice.
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Participant Perspectives and Experiences Entering an Intensively Monitored Antiretroviral Pause (IMAP): Results from the AIDS Clinical Trials Group (ACTG) A5345 Biomarker Study. Diepstra KL, Barr L, Palm D, Hogg E, Mollan K, Henley L, Stover A, Simoni J, Sugarman J, Brown B, Sauceda JA, Deeks SG, Fox L, Gandhi R, Smith DM, Li J, Dubé K (2021). AIDS Research Human Retroviruses.
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Altruism: Scoping review of the literature and future directions for HIV cure-related research. Dubé K, Perry KE, Mathur K, Lo M, Javadi SS, Patel H, Concha-Garcia S, Taylor J, Kaytes A, Dee L, Campbell D, Kanazawa J, Smith D, Gianella S , Auerbach JD, Saberi P, A Sauceda JA.  (2020). Journal of Virus Eradication.
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“I would really want to know that they had my back”: Transgender women’s perceptions of HIV cure-related research in the United States. Poteat T, Aqil A, Corbett D, Evans D, Dubé K (2020). PLoS ONE.
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Multi-stakeholder consensus on a target product profile for an HIV cure. Lewin SR, Attoye T, Bansbach C, Doehle B, Dubé K, Dybul M, SenGupta D, Jiang A, Johnston R, Lamplough R, McCune JM, Nabel GJ, Ndung'u T, Pottage J, Ripin D, Rooney JF, Sikazwe I, Nsubuga M, Warren M, Deeks SG; Sunnylands 2019 Working Group. (2020). Lancet HIV.
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Re-examining the HIV 'functional cure' oxymoron: Time for precise terminology? Dubé K, Willenberg L, Dee L, Sylla L, Taylor J, Roebuck C, Palm D, Campbell D, Newton L, Patel H, Perry KE, Kanazawa J, Gerrard J, Brown B, Saberi P, Sauceda JA, Peluso MJ.  (2020). Journal of Virus Eradication.
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The LAIs Are Coming! Implementation Science Considerations for Long-Acting Injectable Antiretroviral Therapy in the United States: A Scoping Review. Kanazawa JT, Saberi P, Sauceda JA, Dubé K.  AIDS Research Human Retroviruses.
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"[It] is now my responsibility to fulfill that wish:" Clinical and rapid autopsy staff members' experiences and perceptions of HIV reservoir research at the end of life. Perry KE, Taylor J, Patel H, Javadi SS, Mathur K, Kaytes A, Concha-Garcia S, Little S, Smith D, Gianella S, Dubé K. (2020). PLoS One.
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Reasons People Living With HIV Might Prefer Oral Daily Antiretroviral Therapy, Long-Acting Formulations, or Future HIV Remission Options. Dube K, Campbell DM, Perry KE, Kanazawa JT, Saberi P, Sauceda JA, Poteat T, Evans D (2020). AIDS Research Human Retroviruses.
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Operationalizing HIV cure-related trials with analytic treatment interruptions during the SARS-CoV-2 pandemic: A collaborative approach. Peluso, MJ, Dee L, Shao S, Taylor J, Campbell, Collins S, Gandhi M, Johnston R, Deeks SG, Sauceda JA, Dubé K (2020). Clinical Infectious Disease.
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"My death will not [be] in vain": Testimonials from Last Gift Rapid Research Autopsy Study participants living with HIV at the end of life. Perry KE, Dubé K, Concha-Garcia S, Patel H, Kaytes A, Taylor J, Javadi SS, Mathur K, Lo M, Brown B, Sauceda J, Wohl DA, Little SJ, Hendrickx S, Rawlings S, Smith DM, Gianella S  (2020). AIDS Research and Human Retroviruses.
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Perceptions of next-of-kin/loved ones about Last Gift Rapid Research Autopsy Study enrolling people with HIV/AIDS at the end-of-life: A qualitative interview study. Dubê K, Patel H, Concha-Garcia S, Perry KE, Mathur K, Javadi SS, Taylor J, Kaytes A, Brown B, Sauceda J, Little SJ, Hendrickx S, Rawlings S, Smith DM, Gianella S (2020). AIDS Research and Human Retroviruses.
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Willingness to risk death endpoint in HIV cure-related research with otherwise healthy volunteers is misleading. Dubé, K., & Dee, L. (2020). Journal of Virus Eradication, 6.
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Participant perspectives in an HIV cure-related trial conducted exclusively in women in the United States: Results from AIDS Clinical Trials Group (ACTG) 5366. Dubé K, Hosey L, Starr K, Barr L, Evans D, Hoffman E, Campbell D, Simoni J, Sugarman J, Sauceda J, Brown B, Diepstra KL, Godfrey C, Kuritzkes DR, Wohl DA, Gandhi R, Scully E. (2020). AIDS Research and Human Retroviruses.
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A collaborative, multidisciplinary approach to HIV transmission risk mitigation during analytic treatment interruption. Peluso MJ, Dee L, Campbell D, Taylor J, Hoh R, Rutishauser RL, Sauceda J, Deeks SG and Dubé, K. (2020). Journal of Virus Eradication, 6.
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Applying the Behavioural and Social Sciences Research (BSSR) Functional Framework to HIV Cure Research. Dubé K, Auerbach JD, Stirratt MJ, Gaist P (2019). Journal of the International AIDS Society.
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What lessons it might teach us? Community engagement in HIV research. Karris MY, Dubé K, and Moore AA (2019). Current Opinion HIV/AIDS.

The dose response: Perceptions of people living with HIV in the United States on alternatives to oral daily antiretroviral therapy. Dubé K, Eskaf S, Evans D, Sauceda J, Saberi P, Brown B, Averitt D, Martel K, Meija M, Campbell D, Barr L, Kanazawa J, Perry K, Patel H, Luter S, Poteat T, Auerbach JD, Wohl DA. (2019). AIDS Research and Human Retroviruses.
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Acceptability of cell and gene therapy for curing HIV infection among people living with HIV in the Northwestern United States: A qualitative study. Dubé K, Simoni J, Louella M, Sylla L, Mohamed ZH, Patel H, Luter S, Collier AC. (2019). AIDS Research and Human Retroviruses.
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Putting participants at the centre of HIV cure research. Dubé K, Barr L, Palm D, Brown B, Taylor J. (2019). Lancet HIV.
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Revisiting the ‘sterilising cure’ terminology: a call for more patient-centred perspectives on HIV cure-related research. Newton L, Necochea R, Palm D, Taylor J, Barr L, Patel H, Nathan A, Gerrard J, Sylla L, Brown B, Dubé K (2019). Journal of Virus Eradication, 5.
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Recommendations for analytical antiretroviral treatment interruptions in HIV research trials—report of a consensus meeting. Julg B, Dee L, Ananworanich J, Barouch DH, Bar K, Caskey M, Colby DJ, Dawson L, Dong KL, Dubé K, Eron J, Frater J, Gandhi RT, Geleziunas R, Goulder P, Hanna GJ, Jefferys R, Johnston R, Kuritzkes D, Li JZ, Likhitwonnawut U, Van Lunzen J, Martinez-Picado J, Miller V, Montaner LJ, Nixon DF, Palm D, Pantaleo G, Peay H, Persaud D, Salzwedel J, Salzwedel K, Schacker T, Sheikh V, Søgaard OS, Spudich S, Stephenson K, Sugarman J, Taylor J, Tebas P, Tiemessen CT, Tressler R, Weiss CD, Zheng L, Robb ML, Michael NL, Mellors JW, Deeks SG, Walker BD (2019). Lancet HIV.
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Ethical considerations for HIV cure-related research at the end of life. Dubé K, Gianella S, Concha-Garcia S, Little SJ, Kaytes A, Taylor J, Mathur K, Javadi S, Nathan A, Patel H, Luter S, Philpott-Jones S, Brown B, Smith D. (2018). BMC Medical Ethics, 19(83).
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Willingness to participate in HIV research at the end of life (EOL). Katya Prakash, Sara Gianella , Karine Dubé, Jeff Taylor, GaYoung Lee, Davey M. Smith (2018). PLoS ONE, 13(7).
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Use of "eradication" in HIV cure-related research: A public health debate. Dubé K, Luter S, Lesnar B, Newton L, Galea J, Brown B, Gianella S. (2018). BMC Public Health, 18(245).
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Research on HIV cure: Mapping the ethics landscape. Dubé K, Sylla L, Dee L, Taylor J, Evans D, Bruton CD, Gilbertson A, Gralinkski L, Brown B, Skinner A, Weiner BJ, Greene SB, Corneli A, Adimora AA, Tucker JD, Rennie S. (2017). PLoS Medicine, 14(12), e1002470.
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Crucial but understudied: Incentives in HIV research. Brown B, Galea JT, Dubé K. (2017). Lancet HIV.
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If we build It, will they come? Perceptions of HIV cure-related research by people living with HIV in four U.S. cities – A qualitative focus group study. Sylla LN, Evans D, Taylor J, Gilbertson AL, Palm D, Auerbach JD, Dubé K. (2017). AIDS Research and Human Retroviruses.
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Interrupting antiretroviral treatment in HIV cure research: Scientific and ethical considerations. Garner SA, Rennie S, Ananworanich J, Dubé K, Margolis DM, Sugarman J, Tressler R, Gilbertson A, Dawson L.  (2017). Journal of Virus Eradication, 3(2), 82-4.
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Perceptions of equipoise, risk-benefit ratios, and “otherwise healthy volunteers” in the context of early-phase HIV cure research in the United States: A qualitative inquiry. Dubé K, Dee L, Evans D, Sylla L, Taylor J, Brown B, Miller V, Corneli A, Skinner A, Greene SB, Tucker JD, Rennie S.  (2017). Journal of Empirical Research on Human Research Ethics.
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Reply to commentary: “Are HIV-infected candidates for participation in risky cure-related studies otherwise healthy.”. Dubé K, Sylla L, Dee L. (2017). Journal of Empirical Research on Human Research Ethics.
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‘Well, it’s the risk of the unknown… right?’: A qualitative study of perceived risks and benefits of HIV cure research in the United States. Dubé K, Taylor J, Sylla L, Evans D, Dee L, Burton A, Willenberg L, Rennie S, Skinner A, Tucker JD, Weiner BJ, Greene SB.  (2017). PLoS One, 12(1).
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'We need to deploy them very thoughtfully and carefully’: Perceptions of analytical treatment interruptions in HIV cure research in the United States – A qualitative inquiry. Dubé K, Evans D, Dee L, Sylla L, Taylor J, Skinner A, Weiner BJ, Greene SB, Rennie S, Tucker JD. (2017). AIDS Research and Human Retroviruses.
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Willingness to participate and take risks in HIV cure research: survey results from 400 people living with HIV in the U.S. Dubé K, Evans D, Sylla L, Taylor J, Weiner BJ, Skinner A, Thirumurthy H, Tucker JD, Rennie S, Greene SB. (2017). Journal of Virus Eradication, 3.
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Towards a multi-disciplinary HIV cure research agenda: Integrating the social science with biomedical and clinical research. Grossman CI, Ross AL, Auerbach JD, Ananworanich J, Dubé K, Tucker JD, Noseda V, Possas C, Rausch D.  (2016). Trends in Microbiology, 24(1), 5-11.
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How does the timing of antiretroviral therapy initiation in acute infected affect HIV reservoir? Ananworanich J, Dubé K, Chomont N.  (2015). Current Opinion in HIV/AIDS, 10(1), 18-28.
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Participation in HIV cure research: A scoping review of the proxy literature and implications for future research. Dubé K, Ramirez C, Handibode J, Taylor J, Skinner A, Greene SB, Tucker JD.  (2015). The Journal of Virus Eradication, 1.
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Framing expectations in early HIV cure research. Dubé K, Henderson GE, Margolis DM.  (2014). Trends in Microbiology – Science and Society, 22(10), 547-9.
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HIV incidence in a cohort of women at higher risk in Beira, Mozambique: Prospective study 2009 – 2012. Dubé K, Zango A, Wijgert Jvd, Meque I, Ferro JJ, Cumbe F, Chen PL, Ma S, Jolles E, Fumo A, Robb ML, Feldblum PJ. (2014). PLoS One, 9(1).
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Validation of the cepheid GeneXpert for detecting Ebola virus in Semen. Loftis AJ, Quellie S, Chason K, Sumo E, Toukolon M, Otieno Y, Ellerbrok H, Hobbs MM, Hoover D, Dube K, Wohl DA, Fischer WA II.  (2017). Journal of Infectious Diseases.
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Willingness to participate in future HIV prevention trials in Beira, Mozambique. Meque I, Dubé K, Bierhuizen L, Zango A, Veldhuijzen N, Cumbe F, Feldblum PJ, Wijgert Jvd. (2014). African Journal of AIDS Research, 13(4), 393-8.
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Stigma and Ebola survivorship in Liberia: Results from a longitudinal cohort study. Overholt L, Wohl DA, Fischer II WA, Westreich D, Tozay S, Reeves E, Pewu K, Adjasso D, Hoover D, Merenbloom C, Johnson H, Williams G, Conneh T, Diggs J, Buller A, McMillian D, Hawks D, Dube K, Brown J (2018). PLOS One, 13(11).
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Ebola virus RNA detection in semen more than two years after resolution of acute Ebola virus infection. Fischer WA II, Brown J, Wohl DA, Loftis AJ, Tozay S, Reeves E, Pewu K, Gorvego G, Quellie S, Cunningham CK, Merenbloom C, Napravnik S, Dubé K, Adjasoo D, Jones E, Bonarwolo K, Hoover D. (2017). Open Forum Infectious Diseases.
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"We are looking at the future right now": community acceptability of a home-based viral load test device in the context of HIV cure-related research with analytical treatment interruptions in the United States.  Dubé, K., Kanazawa, J., Roebuck, C., Johnson, S., Carter, W. B., Dee, L., Peterson, B., Lynn, K. M., Lalley-Chareczko, L., Hiserodt, E., Kim, S., Rosenbloom, D., Evans, B. R., Anderson, M., Hazuda, D. J., Shipley, L., Bateman, K., Howell, B. J., Mounzer, K., Tebas, P., Montaner, L. J. (2022). HIV research & clinical practice .
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Lessons learned from the Last Gift study: ethical and practical challenges faced while conducting HIV cure-related research at the end of life. Kanazawa J, Rawlings SA, Hendrickx S, Gianella S, Concha-Garcia S, Taylor J, Kaytes A, Patel H, Ndukwe S, Little SJ, Smith D, Dubé K. (2022). J Med Ethics.
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Education