Gillings School Directory

Karine Dubé, DrPH

Karine Dube headshot

Karine Dubé, DrPH

Assistant Professor
Public Health Leadership Program
Visiting Professor, Center for AIDS Prevention Studies (CAPS)
University of California San Francisco (UCSF) (2020 – 2022)
  • MacGavran-Greenberg 4108
  • CB 7469
  • Chapel Hill, NC 27599
  • USA
Karine Dubé, DrPH, MPhil (Oxon) is a socio-behavioral researcher and an experienced research program manager. Her current research work focuses on integrating socio-behavioral research as part of HIV cure trials in the United States. Karine bridges biomedical research, socio-behavioral sciences, ethics, patient and community engagement and public health in infectious diseases research. She has over 15 years of experience in infectious diseases-related work, including Ebola and HIV prevention and cure-related research. She has also worked in the areas of malaria control and treatment, HSV-2 prevention and treatment, sexual and reproductive health and family planning.
 
Karine is an NIH-funded researcher integrating participant-centered outcomes and socio-behavioral assessments in AIDS Clinical Trials Group (ACTG) studies. Karine supports several groups integrating socio-behavioral sciences and empirical ethics related to HIV cure-related research, notably the UCSD Last Gift team, UCSF SCOPE team, the amfAR Institute for HIV Cure Research, the BEAT-HIV Collaboratory (Wistar Institute), and the City of Hope/California Institute of Regenerative Medicine (CIRM). She served as co-investigator on the Social and Ethical Aspects of Curing HIV Infection (searcHIV) working group at UNC Chapel Hill from 2014 – 2017. Karine previously served as a research program manager for the Collaboratory of AIDS Researchers for Eradication (CARE) at UNC-Chapel Hill. She also is the co-founder and co-leader of the CUREiculum (http://www.avac.org/cureiculum), a collaborative program aimed at making HIV cure science accessible to the community and the HIV research field. 

In 2016, she managed the UNC-CH – ClinicalRM – ELWA (Liberia) Ebola consortium. She led a vaccine cohort development program, two HIV-1C prospective incidence studies and a clinical research site capacity development effort in Maputo, Beira and Chókwè, Mozambique with the United States Military HIV Research Program (MHRP)/Walter Reed Army Institute of Research/Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF) and FHI 360 (from 2008–2013). Karine also has served as a research and program analyst with amfAR, the Foundation for AIDS Research (2007 – 2008).
 
She currently serves as Associate Editor for BMC Public Health and Academic Editor for PLoS One
 

Honors and Awards

Ethics Administrative Supplement to R21-MH118120: Advancing Empirical Research Ethics for HIV Cure Research

2020, National Institute of Mental Health

R21 Grant Funding: Perceptions of Risks and Benefits of Participating in HIV Cure-Related Research among Diverse Youth and Young Adults Living with HIV in the United States

2020, National Institute of Mental Health (NIMH)

R21 Grant Funding: Pilot Integration of Participant-Centered Outcomes in HIV Cure Research in the United States: Implications for Ethical Conduct

2019, National Institute of Mental Health (NIMH)

Arthur B. Holzworth Endowed Scholarship in Health Leadership

2015, University of North Carolina at Chapel Hill

Representative Courses

Introduction to Global Public Health (SPHG 700) | Syllabus

Global Health Ethics for Global Health Concentration (PUBH 710) | Syllabus

Critical Issues in Global Health (PUBH 711) | Syllabus

Global Health Ethics (PUBH 712) | Syllabus

The AIDS Course- Online (PUBH 725) | Syllabus

Research Activities

- HIV
- Infectious Diseases
- Interdisciplinary Research


Key Publications

Reasons People Living with HIV Might Prefer Oral Daily Antiretroviral Therapy, Long-Acting Formulations, or Future HIV Remission Options. Dube K, Campbell DM, Perry KE, Kanazawa JT, Saberi P, Sauceda JA, Poteat T, Evans D (2020). AIDS Research Human Retroviruses.
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Operationalizing HIV cure-related trials with analytic treatment interruptions during the SARS-CoV-2 pandemic: A collaborative approach. Peluso, MJ, Dee L, Shao S, Taylor J, Campbell, Collins S, Gandhi M, Johnston R, Deeks SG, Sauceda JA, Dubé K (2020). Clinical Infectious Disease.
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"My death will not [be] in vain": Testimonials from Last Gift Rapid Research Autopsy Study participants living with HIV at the end of life. Perry KE, Dubé K, Concha-Garcia S, Patel H, Kaytes A, Taylor J, Javadi SS, Mathur K, Lo M, Brown B, Sauceda J, Wohl DA, Little SJ, Hendrickx S, Rawlings S, Smith DM, Gianella S  (2020). AIDS Research and Human Retroviruses.
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Perceptions of next-of-kin/loved ones about Last Gift Rapid Research Autopsy Study enrolling people with HIV/AIDS at the end-of-life: A qualitative interview study. Dubê K, Patel H, Concha-Garcia S, Perry KE, Mathur K, Javadi SS, Taylor J, Kaytes A, Brown B, Sauceda J, Little SJ, Hendrickx S, Rawlings S, Smith DM, Gianella S (2020). AIDS Research and Human Retroviruses.
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Willingness to risk death endpoint in HIV cure-related research with otherwise healthy volunteers is misleading. Dubé, K., & Dee, L. (2020). Journal of Virus Eradication, 6.
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Participant perspectives in an HIV cure-related trial conducted exclusively in women in the United States: Results from AIDS Clinical Trials Group (ACTG) 5366. Dubé K, Hosey L, Starr K, Barr L, Evans D, Hoffman E, Campbell D, Simoni J, Sugarman J, Sauceda J, Brown B, Diepstra KL, Godfrey C, Kuritzkes DR, Wohl DA, Gandhi R, Scully E. (2020). AIDS Research and Human Retroviruses.
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A collaborative, multidisciplinary approach to HIV transmission risk mitigation during analytic treatment interruption. Peluso MJ, Dee L, Campbell D, Taylor J, Hoh R, Rutishauser RL, Sauceda J, Deeks SG and Dubé, K. (2020). Journal of Virus Eradication, 6.
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Applying the Behavioural and Social Sciences Research (BSSR) Functional Framework to HIV Cure Research. Dubé K, Auerbach JD, Stirratt MJ, Gaist P (2019). Journal of the International AIDS Society.
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What lessons it might teach us? Community engagement in HIV research. Karris MY, Dubé K, and Moore AA (2019). Current Opinion HIV/AIDS.

The dose response: Perceptions of people living with HIV in the United States on alternatives to oral daily antiretroviral therapy. Dubé K, Eskaf S, Evans D, Sauceda J, Saberi P, Brown B, Averitt D, Martel K, Meija M, Campbell D, Barr L, Kanazawa J, Perry K, Patel H, Luter S, Poteat T, Auerbach JD, Wohl DA. (2019). AIDS Research and Human Retroviruses.
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Acceptability of cell and gene therapy for curing HIV infection among people living with HIV in the Northwestern United States: A qualitative study. Dubé K, Simoni J, Louella M, Sylla L, Mohamed ZH, Patel H, Luter S, Collier AC. (2019). AIDS Research and Human Retroviruses.
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Putting participants at the centre of HIV cure research. Dubé K, Barr L, Palm D, Brown B, Taylor J. (2019). Lancet HIV.
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Revisiting the ‘sterilising cure’ terminology: a call for more patient-centred perspectives on HIV cure-related research. Newton L, Necochea R, Palm D, Taylor J, Barr L, Patel H, Nathan A, Gerrard J, Sylla L, Brown B, Dubé K (2019). Journal of Virus Eradication, 5.
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Recommendations for analytical antiretroviral treatment interruptions in HIV research trials—report of a consensus meeting. Julg B, Dee L, Ananworanich J, Barouch DH, Bar K, Caskey M, Colby DJ, Dawson L, Dong KL, Dubé K, Eron J, Frater J, Gandhi RT, Geleziunas R, Goulder P, Hanna GJ, Jefferys R, Johnston R, Kuritzkes D, Li JZ, Likhitwonnawut U, Van Lunzen J, Martinez-Picado J, Miller V, Montaner LJ, Nixon DF, Palm D, Pantaleo G, Peay H, Persaud D, Salzwedel J, Salzwedel K, Schacker T, Sheikh V, Søgaard OS, Spudich S, Stephenson K, Sugarman J, Taylor J, Tebas P, Tiemessen CT, Tressler R, Weiss CD, Zheng L, Robb ML, Michael NL, Mellors JW, Deeks SG, Walker BD (2019). Lancet HIV.
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Ethical considerations for HIV cure-related research at the end of life. Dubé K, Gianella S, Concha-Garcia S, Little SJ, Kaytes A, Taylor J, Mathur K, Javadi S, Nathan A, Patel H, Luter S, Philpott-Jones S, Brown B, Smith D. (2018). BMC Medical Ethics, 19(83).
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Willingness to participate in HIV research at the end of life (EOL). Katya Prakash, Sara Gianella , Karine Dubé, Jeff Taylor, GaYoung Lee, Davey M. Smith (2018). PLoS ONE, 13(7).
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Use of "eradication" in HIV cure-related research: A public health debate. Dubé K, Luter S, Lesnar B, Newton L, Galea J, Brown B, Gianella S. (2018). BMC Public Health, 18(245).
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Research on HIV cure: Mapping the ethics landscape. Dubé K, Sylla L, Dee L, Taylor J, Evans D, Bruton CD, Gilbertson A, Gralinkski L, Brown B, Skinner A, Weiner BJ, Greene SB, Corneli A, Adimora AA, Tucker JD, Rennie S. (2017). PLoS Medicine, 14(12), e1002470.
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Crucial but understudied: Incentives in HIV research. Brown B, Galea JT, Dubé K. (2017). Lancet HIV.
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If we build It, will they come? Perceptions of HIV cure-related research by people living with HIV in four U.S. cities – A qualitative focus group study. Sylla LN, Evans D, Taylor J, Gilbertson AL, Palm D, Auerbach JD, Dubé K. (2017). AIDS Research and Human Retroviruses.
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Interrupting antiretroviral treatment in HIV cure research: Scientific and ethical considerations. Garner SA, Rennie S, Ananworanich J, Dubé K, Margolis DM, Sugarman J, Tressler R, Gilbertson A, Dawson L.  (2017). Journal of Virus Eradication, 3(2), 82-4.
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Perceptions of equipoise, risk-benefit ratios, and “otherwise healthy volunteers” in the context of early-phase HIV cure research in the United States: A qualitative inquiry. Dubé K, Dee L, Evans D, Sylla L, Taylor J, Brown B, Miller V, Corneli A, Skinner A, Greene SB, Tucker JD, Rennie S.  (2017). Journal of Empirical Research on Human Research Ethics.
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Reply to commentary: “Are HIV-infected candidates for participation in risky cure-related studies otherwise healthy.”. Dubé K, Sylla L, Dee L. (2017). Journal of Empirical Research on Human Research Ethics.
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‘Well, it’s the risk of the unknown… right?’: A qualitative study of perceived risks and benefits of HIV cure research in the United States. Dubé K, Taylor J, Sylla L, Evans D, Dee L, Burton A, Willenberg L, Rennie S, Skinner A, Tucker JD, Weiner BJ, Greene SB.  (2017). PLoS One, 12(1).
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'We need to deploy them very thoughtfully and carefully’: Perceptions of analytical treatment interruptions in HIV cure research in the United States – A qualitative inquiry. Dubé K, Evans D, Dee L, Sylla L, Taylor J, Skinner A, Weiner BJ, Greene SB, Rennie S, Tucker JD. (2017). AIDS Research and Human Retroviruses.
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Willingness to participate and take risks in HIV cure research: survey results from 400 people living with HIV in the U.S. Dubé K, Evans D, Sylla L, Taylor J, Weiner BJ, Skinner A, Thirumurthy H, Tucker JD, Rennie S, Greene SB. (2017). Journal of Virus Eradication, 3.
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Towards a multi-disciplinary HIV cure research agenda: Integrating the social science with biomedical and clinical research. Grossman CI, Ross AL, Auerbach JD, Ananworanich J, Dubé K, Tucker JD, Noseda V, Possas C, Rausch D.  (2016). Trends in Microbiology, 24(1), 5-11.
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How does the timing of antiretroviral therapy initiation in acute infected affect HIV reservoir? Ananworanich J, Dubé K, Chomont N.  (2015). Current Opinion in HIV/AIDS, 10(1), 18-28.
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Participation in HIV cure research: A scoping review of the proxy literature and implications for future research. Dubé K, Ramirez C, Handibode J, Taylor J, Skinner A, Greene SB, Tucker JD.  (2015). The Journal of Virus Eradication, 1.
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Framing expectations in early HIV cure research. Dubé K, Henderson GE, Margolis DM.  (2014). Trends in Microbiology – Science and Society, 22(10), 547-9.
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HIV incidence in a cohort of women at higher risk in Beira, Mozambique: Prospective study 2009 – 2012. Dubé K, Zango A, Wijgert Jvd, Meque I, Ferro JJ, Cumbe F, Chen PL, Ma S, Jolles E, Fumo A, Robb ML, Feldblum PJ. (2014). PLoS One, 9(1).
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Validation of the cepheid GeneXpert for detecting Ebola virus in Semen. Loftis AJ, Quellie S, Chason K, Sumo E, Toukolon M, Otieno Y, Ellerbrok H, Hobbs MM, Hoover D, Dube K, Wohl DA, Fischer WA II.  (2017). Journal of Infectious Diseases.
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Willingness to participate in future HIV prevention trials in Beira, Mozambique. Meque I, Dubé K, Bierhuizen L, Zango A, Veldhuijzen N, Cumbe F, Feldblum PJ, Wijgert Jvd. (2014). African Journal of AIDS Research, 13(4), 393-8.
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Stigma and Ebola survivorship in Liberia: Results from a longitudinal cohort study. Overholt L, Wohl DA, Fischer II WA, Westreich D, Tozay S, Reeves E, Pewu K, Adjasso D, Hoover D, Merenbloom C, Johnson H, Williams G, Conneh T, Diggs J, Buller A, McMillian D, Hawks D, Dube K, Brown J (2018). PLOS One, 13(11).
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Ebola virus RNA detection in semen more than two years after resolution of acute Ebola virus infection. Fischer WA II, Brown J, Wohl DA, Loftis AJ, Tozay S, Reeves E, Pewu K, Gorvego G, Quellie S, Cunningham CK, Merenbloom C, Napravnik S, Dubé K, Adjasoo D, Jones E, Bonarwolo K, Hoover D. (2017). Open Forum Infectious Diseases.
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Education

DrPH, Public Health, University of North Carolina at Chapel Hill, 2016

MPhil, Development Studies / International Health, Oxford University, 2005

BA, International Studies / Global Health (Minor in Business Administration), University of North Carolina at Chapel Hill, 2003

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