Gillings School Directory
David Couper, PhD
David Couper, PhD
Professor
Department of Biostatistics
Deputy Director
Collaborative Studies Coordinating Center
Dr. David Couper's faculty appointment is in the Collaborative Studies Coordinating Center (CSCC), a unit in the Department of Biostatistics.
Dr. Couper has worked at the CSCC since 1998 and has been the coordinating center (CC) Principal Investigator for several clinical trials and observational studies. He is currently PI of the Coordinating Center for the Atherosclerosis Risk in Communities (ARIC) Study, the ARIC Neurocognitive Study (ARIC-NCS) and the Aging and Cognitive Health Evaluation in Elders (ACHIEVE) clinical trial, as well as the PI of the Genomics and Informatics Center for the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS).
Representative Courses
Intermediate Statistical Methods (BIOS 662)
Design of Public Health Studies (BIOS 668)
Intermediate Linear Models (BIOS 663)
Research Interests
- Data Quality
- Epidemiological Methods
- Longitudinal Data
Service Activities
Member of the (NIH) National Advisory Dental and Craniofacial Research Council (2018-2021)Member of the NC TraCS Data and Safety Monitoring Board (DSMB) since 2005
Service on DSMBs for various NIH-funded studies
On the panel of statistical reviewers for Circulation, the Journal of the American Heart Association, and JAMA Network Open, plus reviewing of manuscripts for various other journals
Regular and ad hoc peer reviewer for NHLBI, NIAMS, NIAID, NIAAA, NHGRI, NIDDK (on hold while serving the National Advisory Dental and Craniofacial Research Council)
Peer review for Singapore's National Medical Research Council (on hold while serving the National Advisory Dental and Craniofacial Research Council)
Key Publications
Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS). R Barr, E Bleecker, D Couper, M Han, E Hoffman, R Kanner, E Kleerup, L Lavange, F Martinez, S Rennard, P Woodruff (2014). Thorax, 69(5), 492-5.
Associations Among 25-Hydroxyvitamin D Levels, Lung Function, and Exacerbation Outcomes in COPD: An Analysis of the SPIROMICS Cohort. Burkes RM, Ceppe AS, Doerschuk CM, Couper D, Hoffman EA, Comellas AP, Barr RG, Krishnan JA, Cooper C, Labaki WW, Ortega VE, Wells JM, Criner GJ, Woodruff PG, Bowler RP, Pirozzi CS, Hansel NN, Wise RA, Brown TT, Drummond MB; SPIROMICS Investigators. (2020). Chest., 157(4), 856-865.
Harmonization of Respiratory Data From 9 US Population-Based Cohorts: The NHLBI Pooled Cohorts Study. Oelsner EC, Balte PP, Cassano PA, Couper D, Enright PL, Folsom AR, Hankinson J, Jacobs DR Jr, Kalhan R, Kaplan R, Kronmal R, Lange L, Loehr LR, London SJ, Navas Acien A, Newman AB, O'Connor GT, Schwartz JE, Smith LJ, Yeh F, Zhang Y, Moran AE, Mwasongwe S, White WB, Yende S, Barr RG. (1970). Am J Epidemiol., 187(11), 2265-2278.
Association of monocyte myeloperoxidase with incident cardiovascular disease: The Atherosclerosis Risk in Communities Study. Oyenuga A.O. Couper D., Matsushita K., Boerwinkle E., Folsom A.R. (2018). PLoS One, 13(10).
SPIROMICS Research Group. Variability in objective and subjective measures affects baseline values in studies of patients with COPD. Anderson W.H., Ha J.W., Couper D.J., O'Neal W.K., Barr R.G., Bleecker E.R., Carretta E.E., Cooper C.B., Doerschuk C.M., Drummond M.B., Han M.K., Hansel N.N., Kim V., Kleerup E.C., Martinez F.J., Rennard S.I., Tashkin D., Woodruff P.G., Paine R. 3rd, Curtis J.L., Kanner R.E. (2017). PLoS One, 12(9).
Small Dense Low-Density Lipoprotein-Cholesterol Concentrations Predict Risk for Coronary Heart Disease: The Atherosclerosis Risk in Communities (ARIC) Study. C Ballantyne, E Boerwinkle, D Couper, J Crosby, R Dodge, J Gaubatz, R Hoogeveen, J Jiang, S Kathiresan, W Sun, S Virani (2014). Arteriosclerosis, thrombosis, and vascular biology, 34(5), 1069-77.
Impact of differential attrition on the association of education with cognitive change over 20 years of follow-up. M Albert, A Alonso, K Bandeen-Roche, L Coker, J Coresh, D Couper, R Gottesman, M Griswold, G Heiss, D Knopman, T Mosley, M Patel, A Penman, M Power, A Rawlings, A Schneider, O Selnes, A Sharrett, L Wagenknecht, B Windham, L Wruck (2014). American Journal of Epidemiology, 179(8), 956-966.
Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events. L Bouter, I Butcher, J Cauley, D Couper, M Criqui, M Cushman, R D'Agostino, G Debacker, A Folsom, F Fowkes, O Franco, R Hamman, B Hedblad, R Heine, W Hiatt, A Hirsch, A Hofman, M Hunink, J Knottnerus, W Koenig, M Kornitzer, R Langer, A Lee, K Masaki, M McDermott, C Meisinger, J Murabito, G Murray, A Newman, P Norman, M Ogren, J Price, C Stehouwer, H Stoffers, K Sutton-Tyrrell, J Witteman (2014). European journal of preventive cardiology, 21(3), 310-20.
Meta-analysis of loci associated with age at natural menopause in African-American women. C Ambrosone, J Andrews, A Arnold, E Bandera, L Bernstein, A Britton, R Brzyski, A Cappola, C Carlson, G Chen, C Chen, D Couper, L Cupples, E Demerath, S Deming, J Dreyfus, M Evans, N Franceschini, M Garcia, M Goodarzi, C Haiman, T Harris, G Heiss, B Henderson, E John, S Kardia, K Kerr, C Kooperberg, L Le Marchand, G Li, Y Liu, C Liu, K Lohman, X Lu, K Marciante, B McKnight, R Millikan, T Mosley, J Murabito, S Musani, M Nalls, N Nock, A Olshan, M Press, B Psaty, L Raffel, A Rajkovic, J Smith, H Taylor, D Vaiyda, M Wellons, B Windham, N Woods, W Zhao, W Zheng, A Zonderman (2014). Human molecular genetics.
Staff/Administrative Duties
Deputy Director of the Collaborative Studies Coordinating Center
Education
PhD, Biostatistics, University of Washington, 1994
MS, Biostatistics, University of Washington, 1991
MSc, Statistics, University of South Africa, 1982
BS, Mathematical Statistics, University of Cape Town, 1977
BSc, Mathematics, University of Cape Town, 1975
