David Couper, PhD

Clinical Professor Department of Biostatistics
Deputy Director Collaborative Studies Coordinating Center

T:(919) 962-3229


137 East Franklin Street

Suite 203

CB #8030

Chapel Hill, NC 27599


Dr. David Couper's faculty appointment is in the Collaborative Studies Coordinating Center (CSCC), a unit in the Department of Biostatistics.

Dr. Couper has worked at the CSCC since 1998 and has been the coordinating center (CC) Principal Investigator for several clinical trials and observational studies. He has been an investigator on the ARIC Study since 1998, and in 2011 he took over as Principal Investigator for the ARIC Study Coordinating Center.

Research Activities

Data Quality

Longitudinal Data

Epidemiological Methods

Service Activities
Currently serving on the North Carolina Translational and Clinical Sciences (TraCS) Institute’s Data and Safety Monitoring Board

Manuscript reviewing for Circulation, JAHA, PLOS ONE, JAMA, JACC and sundry others.

Service on various NIH review panels, primarily for NHLBI and NIAMS.

On International Expert Panel of grant reviewers for Singapore’s National Medical Research Council. Have also done proposal reviewing for California’s Tobacco-Related Disease Research Program and for the Deutsche Forschungsgemeinschaft (German Research Foundation).

Member of the following professional associations: American Statistical Association;  International Biometric Society (Eastern North American Region);  Society for Clinical Trials;  American Heart Association
Staff/Administrative Duties

Deputy Director of the Collaborative Studies Coordinating Center

Key Publications

Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS). R Barr, E Bleecker, D Couper, M Han, E Hoffman, R Kanner, E Kleerup, L Lavange, F Martinez, S Rennard, P Woodruff (2014). Thorax, 69(5), 492-5.

Small Dense Low-Density Lipoprotein-Cholesterol Concentrations Predict Risk for Coronary Heart Disease: The Atherosclerosis Risk in Communities (ARIC) Study. C Ballantyne, E Boerwinkle, D Couper, J Crosby, R Dodge, J Gaubatz, R Hoogeveen, J Jiang, S Kathiresan, W Sun, S Virani (2014). Arteriosclerosis, thrombosis, and vascular biology, 34(5), 1069-77.

Impact of differential attrition on the association of education with cognitive change over 20 years of follow-up. Marilyn Albert, M Albert, Alvaro Alonso, A Alonso, Karen Bandeen-Roche, K Bandeen-Roche, Laura Coker, L Coker, Josef Coresh, J Coresh, David Couper, D Couper, Rebecca Gottesman, R Gottesman, Michael Griswold, M Griswold, Gerardo Heiss, G Heiss, David Knopman, D Knopman, Thomas Mosley, T Mosley, Mehul Patel, M Patel, Alan Penman, A Penman, Melinda Power, M Power, Andreea Rawlings, A Rawlings, Andrea Schneider, A Schneider, Ola Selnes, O Selnes, A. Sharrett, A Sharrett, Lynne Wagenknecht, L Wagenknecht, B. Windham, B Windham, Lisa Wruck, L Wruck (2014). American Journal of Epidemiology, 179(8), 956-966.

Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events. L Bouter, I Butcher, J Cauley, D Couper, M Criqui, M Cushman, R D'Agostino, G Debacker, A Folsom, F Fowkes, O Franco, R Hamman, B Hedblad, R Heine, W Hiatt, A Hirsch, A Hofman, M Hunink, J Knottnerus, W Koenig, M Kornitzer, R Langer, A Lee, K Masaki, M McDermott, C Meisinger, J Murabito, G Murray, A Newman, P Norman, M Ogren, J Price, C Stehouwer, H Stoffers, K Sutton-Tyrrell, J Witteman (2014). European journal of preventive cardiology, 21(3), 310-20.

Meta-analysis of loci associated with age at natural menopause in African-American women. C Ambrosone, J Andrews, A Arnold, E Bandera, L Bernstein, A Britton, R Brzyski, A Cappola, C Carlson, G Chen, C Chen, D Couper, L Cupples, E Demerath, S Deming, J Dreyfus, M Evans, N Franceschini, M Garcia, M Goodarzi, C Haiman, T Harris, G Heiss, B Henderson, E John, S Kardia, K Kerr, C Kooperberg, L Le Marchand, G Li, Y Liu, C Liu, K Lohman, X Lu, K Marciante, B McKnight, R Millikan, T Mosley, J Murabito, S Musani, M Nalls, N Nock, A Olshan, M Press, B Psaty, L Raffel, A Rajkovic, J Smith, H Taylor, D Vaiyda, M Wellons, B Windham, N Woods, W Zhao, W Zheng, A Zonderman (2014). Human molecular genetics.


PhD, Biostatistics, University of Washington, 1994

MS, Biostatistics, University of Washington, 1991

MSc, Statistics, University of South Africa, 1982

BS, Mathematical Statistics, University of Cape Town, 1977

BSc, Mathematics, University of Cape Town, 1975