Wanda Bodnar, PhD

About

Assistant professor Wanda Bodnar specializes in the development and application of analytical methods for the quantitative and qualitative analysis of surrogate markers of exposure, disease or drug treatment. Her area of expertise is bioanalytical mass spectrometry and she has over 25 years’ experience using advanced liquid chromatography and mass spectrometry technologies to analyze small molecules and peptides in a variety of matrices.
Dr. Bodnar was Director of the Mass Spectrometry Core Facility in the Department of Environmental Sciences and Engineering from 2009 to mid-2018 and currently serves as the Scientific Program Analyst for the North Carolina Per- and Polyfluoroalkyl Substance (PFAS)Testing Network.  In response to the mandate of the NC General Assembly, the NC Policy Collaboratory assembled this network of faculty experts and researchers from institutions of higher education across the state to address concerns regarding the presence of PFAS, including GenX, in our drinking water resources.  Dr. Bodnar collaborates with investigators at UNC Chapel Hill, NC State University, Duke University, UNC Wilmington, East Carolina University, UNC Charlotte, and North Carolina A & T State University to facilitate studies in water quality research including: detection of legacy and emerging PFAS (such as GenX) in water sources and air; evaluation of technologies for PFAS removal, and assessment of potential adverse health effects related to exposure.

Wanda Bodnar in the Gillings News

Research Activities

Bioanalytical mass spectrometry
Biomarker discovery and validation
Drug metabolism and Pharmacokinetics

Key Publications

Measurement of endogenous versus exogenous formaldehyde-induced DNA-protein crosslinks in animal tissues by stable isotope labeling and ultrasensitive mass spectrometry. Yongquan Lai, Rui Yu, Hadley J. Hartwell, Benjamin C. Moeller, Wanda M. Bodnar, James A. Swenberg (2016). Cancer Research, 76(9), 2652-2661.

The Contribution of Peroxisome Proliferator-Activated Receptor Alpha to the Relationship Between Toxicokinetics and Toxicodynamics of Trichloroethylene. Hongsik S. Yoo, James A. Cichocki, Sungkyoon Kim, Abhishek Venkatratnam, Yasuhiro Iwata, Oksana Kosyk, Wanda Bodnar, Stephen Sweet, Anthony Knap, Terry Wade, Jerry Campbell, Harvey J. Clewell, Stepan B. Melnyk, Weihsueh A. Chiu, Ivan Rusyn (2015). Toxicological Sciences, 147(2), 339-349.

Placental Cadmium Levels Are Associated with Increased Preeclampsia Risk. Jessica E. Laine, Paul Ray, Wanda Bodnar, Peter H. Cable, Kim Boggess, Steven Offenbacher, Rebecca C. Fry (2015). PloS One, 10(9), e0139341.

The Endogenous Exposome. Jun Nakamura, Esra Mutlu, Vyom Sharma, Leonard Collins, Wanda Bodnar, Rui Yu, Yongquan Lai, Benjamin Moeller, Kun Lu, James Swenberg (2014). DNA Repair, 19.

Gut microbiome phenotypes driven by host genetics affect arsenic metabolism. Kun Lu, Ridwan Mahbub, Peter H. Cable, Hongyu Ru, Nicola M. Parry, Wanda M. Bodnar, John S. Wishnok, Miroslav Styblo, James A. Swenberg, James G. Fox, Steven R. Tannenbaum  (2014). Chemical Research in Toxicology, 27(2), 172-174.

Tracing the Biotransformation of Polycyclic Aromatic Hydrocarbons in Contaminated Soil Using Stable Isotope-Assisted Metabolomics. Zhenyu Tian, Joaquim Vila, Miao Yu, Wanda Bodnar, Michael D. Aitken (2018). Environmental Science & Technology Letters, 5(2), 103−109.

Trisaminohexyl isocyanurate, a urinary biomarker of HDI isocyanurate exposure. Zachary Robbins, Wanda Bodnar, Zhenfa Zhang, Avram Gold, Leena A. Nylander-French (2018). J Chromatography B., .(1076), 117-129.

Editor’s Highlight: Collaborative Cross mouse population enables refinements to characterization of the variability in toxicokinetics of trichloroethylene and provides genetic evidence for the role of PPAR pathway in its oxidative metabolism. Abishek Venkatratnam, Shinji Furuya, Oksana Kosyk, Avram Gold, Wanda Bodnar, Kranti Konganti, David W. Threadgill, Kevin M. Gillespie, David L. Aylor, Fred A. Wright, Weihsueh A. Chiu, Ivan Rusyn  (2017). Toxicological Sciences, 158(1), 48-62.

Pharmaceutical occurrence in groundwater and surface waters in forests land-applied with municipal wastewater. Andrew D. McEachran, Damian Shea, Wanda Bodnar, Elizabeth Guthrie Nichols (2016). Environmental Toxicology and Chemistry, 35(4), 898-905.

Placental Cadmium Levels Are Associated with Increased Preeclampsia Risk. Jessica E. Laine, Paul Ray, Wanda Bodnar, Peter H. Cable, Kim Boggess, Steven Offenbacher, Rebecca C. Fry (2015). PloS One, 10(9).

Education