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Gillings School Directory
Wanda Bodnar, PhD
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Wanda Bodnar, PhD

Assistant Professor
Department of Environmental Sciences and Engineering
Director
UNC Biomarker Mass Spectrometry Core Facility
Director, Molecular Analysis Facility Core
UNC Center for Environmental Health and Susceptibility
Co-Leader, Chemistry Core
UNC Superfund Research Program

Assistant professor Wanda Bodnar specializes in the development and application of analytical methods for the quantitative and qualitative analysis of surrogate markers of exposure, disease and drug treatment. Her area of expertise is bioanalytical mass spectrometry and she has over 20 years experience using this technology to analyze small molecules and peptides.

Her laboratory, the Biomarker Mass Spectrometry Core Facility, collaborates with investigators from multiple disciplines to analyze samples of an environmental and/or biological nature with the goal of understanding the relationships between exposures and the development and progression of human diseases.

Ongoing projects include assessment of DNA and protein adducts as markers of oxidative stress, DNA damage, chemical exposure, identification and quantitation of oxidative and phase II metabolites from in vitro and in vivo studies, and quantitation of heavy metals and other elements in diverse matrices.

Research Activities

Bioanalytical mass spectrometry
Peptide characterization
Proteomics
Drug metabolism

Key Publications

Measurement of endogenous versus exogenous formaldehyde-induced DNA-protein crosslinks in animal tissues by stable isotope labeling and ultrasensitive mass spectrometry. Yongquan Lai, Rui Yu, Hadley J. Hartwell, Benjamin C. Moeller, Wanda M. Bodnar, James A. Swenberg (2016). Cancer Research, 76(9), 2652-2661.

The Contribution of Peroxisome Proliferator-Activated Receptor Alpha to the Relationship Between Toxicokinetics and Toxicodynamics of Trichloroethylene. Hongsik S. Yoo, James A. Cichocki, Sungkyoon Kim, Abhishek Venkatratnam, Yasuhiro Iwata, Oksana Kosyk, Wanda Bodnar, Stephen Sweet, Anthony Knap, Terry Wade, Jerry Campbell, Harvey J. Clewell, Stepan B. Melnyk, Weihsueh A. Chiu, Ivan Rusyn (2015). Toxicological Sciences, 147(2), 339-349.

Placental Cadmium Levels Are Associated with Increased Preeclampsia Risk. Jessica E. Laine, Paul Ray, Wanda Bodnar, Peter H. Cable, Kim Boggess, Steven Offenbacher, Rebecca C. Fry (2015). PloS One, 10(9), e0139341.

The Endogenous Exposome. Jun Nakamura, Esra Mutlu, Vyom Sharma, Leonard Collins, Wanda Bodnar, Rui Yu, Yongquan Lai, Benjamin Moeller, Kun Lu, James Swenberg (2014). DNA Repair, 19.

Gut microbiome phenotypes driven by host genetics affect arsenic metabolism. Kun Lu, Ridwan Mahbub, Peter H. Cable, Hongyu Ru, Nicola M. Parry, Wanda M. Bodnar, John S. Wishnok, Miroslav Styblo, James A. Swenberg, James G. Fox, Steven R. Tannenbaum  (2014). Chemical Research in Toxicology, 27(2), 172-174.

Education

PhD, Chemistry, University of Virginia, 1993

BA, Chemistry, Middlebury College, 1989

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