Ralph S. Baric, PhD

Professor Department of Epidemiology

T:(919) 966-3895

F:(919) 966-2089


3304 Michael Hooker Research Building

CB #7435

Chapel Hill, NC 27599


Honors and Awards

Harvey Weaver Scholar
1986, National Multiple Sclerosis Society

Established Investigator Award
1994, American Heart Association

Innovation Award for Faculty Research
2011, UNC-CH

Research Interest
  • Infectious Disease
Key Publications

Mechanisms of GII.4 norovirus persistence in human populations. Ralph Baric, Jennifer Cannon, Eric Donaldson, Lisa Lindesmith, Anna LoBue, Jan Vinje, Du-Ping Zheng (2008). PLoS Medicine, 5(2), 0269-0290.

Structural basis for potent cross-neutralizing human monoclonal antibody protection against lethal human and zoonotic severe acute respiratory syndrome coronavirus challenge. Ralph Baric, Davide Corti, Eric Donaldson, Antonio Lanzavecchia, Barry Rockx, Timothy Sheahan, Konrad Stadler (2008). Journal of Virology, 82(7), 3220-3235.

Synthetic reconstruction of zoonotic and early human severe acute respiratory syndrome coronavirus isolates that produce fatal disease in aged mice. et al., Ralph Baric, Mark Cameron, Eric Donaldson, Jack Harkema, Mark Heise, David Kelvin, Raymond Pickles, Barry Rockx, Timothy Sheahan, Amy Sims (2007). Journal of Virology, 81(14), 7410-7423.

Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants. et al., Ralph Baric, Kristopher Curtis, Nancy Davis, Damon Deming, Eric Donaldson, Jack Harkema, Mark Heise, Robert Johnston, Raymond Pickles, Timothy Sheahan, Amy Sims, Mehul Suthar, Ande West, Alan Whitmore, Boyd Yount (2006). PLoS Medicine, 3(12), 2359-2375.

Rewiring the severe acute respiratory syndrome coronavirus (SARS-CoV) transcription circuit: Engineering a recombination-resistant genome. Ralph Baric, Lisa Lindesmith, Rhonda Roberts, Boyd Yount (2006). Proceedings of the National Academy of Sciences of the United States of America, 103(33), 12546-12551.


Postdoc, Microbiology, University of Southern California, 1986

PhD, Microbiology, North Carolina State University, 1982

BS, Zoology, North Carolina State University, 1977