Long Ping Victor Tse, PhD

About

Tse has been working in the virology field since he was an undergraduate student, from bacteriophages to pathogenic human viruses. His research focuses on the basic virology and vaccinology of negative sense RNA viruses, including influenza, dengue and Coronaviruses. He also engaged in the practical applications of adeno-associated viruses (AAVs), which are the safest vectors for gene therapy applications. 

Tse's major contributions include the development of the next generation AAV capsids that are able to evade neutralizing antibodies, increase transduction efficiency, and target specific tissues. His work on AAV has led to three first-author publications and two patent applications licensed to StrideBio. Tse has performed extensive research on influenza pathogenesis and vaccine development and discovered three independent influenza activation pathways by alternative host and bacterial proteases.

Honors and Awards

Abstract Travel Award of the 32nd Meeting of ASV, State College, PA
2012

Meritorious Abstract Travel Award of the 20th Meeting of ASGCT, Washington DC
2017

Meritorious Abstract Travel Award of the 21st Meeting of ASGCT, Chicago, IL
2018

Teaching Interests

Besides engaging in scientific discoveries, Tse has been actively involved in mentoring undergraduate and graduate students. He has enthusiastically embraced the opportunities to mentor students in research (>10 students/technicians).

Key Publications

Mapping and Engineering Functional Domains of the Assembly Activating Protein of Adeno-Associated Viruses. Tse LV, Moller-Tank S, Meganck RM, Asokan A. (2018). J Virol, 92(14), e00393-18.

Structure-Guided Evolution of Antigenically Distinct Adeno-Associated Virus Variants for Immune Evasion. Tse LV, Klinc KA, Madigan VJ, Castellanos Rivera RM, Wells LF, Havlik LP, Smith JK, Agbandje-McKenna M, Asokan A. (2017). Proc Natl Acad Sci USA, 114(24), E4812-E4821.

Virus Binding and Internalization Assay for Adeno-Associated Virus. Berry GE, Tse LV. (2017). Bio-protocol, 7(2).

Strategies to Circumvent Humoral Immunity to AAV Vectors. Tse LV, Moller-Tank S, Asokan A. (2015). Expert Opin Biol Ther, 15(6), 845-55.

Equine and Canine Influenza H3N8 Viruses Show Minimal Biological Differences Despite Phylogenetic Divergence. Feng KH, Gonzalez G, Deng L, Yu H, Tse LV, Huang L, Huang K, Wasik BR, Zhou B, Wentworth DE, Holmes EC, Chen X, Varki A, Murcia PR, Parrish CR.  (2015). J Virol., 89(13), 6860-73.

Modification of The Hemagglutinin Cleavage Site Allows Indirect Activation of Avian Influenza Virus H9N2 by Bacterial Staphylokinase. Tse LV, Whittaker GR. (2015). Virology, 482(1), 1-8.

A Novel Activation Mechanism of Avian Influenza Virus H9N2 by Furin. Tse LV, Hamilton AM, Friling T, Whittaker GR. (2014). J Virol., 88(3), 1673-83.

Plasmin-Mediated Activation of Pandemic H1N1 Influenza Virus Hemagglutinin Independent of the Viral Neuramindase. Tse LV, Marcano VC, Huang W, Pocwierz MS, Whittaker GR.  (2013). J Virol., 87(9), 5161-9.

Antibody-Based Immuno-Plaque Assay of Influenza A Virus. Tse LV, Whittaker GR. (2013). Bio-protocol, 3(21).

Characterization of a Recombination Canine Coronavirus with a Distinct Receptor-Binding (S1) Domain. Regan AD, Millet JK, Tse LV, Chillag Z, Rinaldi VD, Licitra BN, Dubovi EJ, Town CD, Whittaker GR.  (2012). Virology, 430(2), 90-9.

Target Site Recognition by a Diversity-Generating Retroelement.  Guo H, Tse LV, Nieh AW, Czornyj E, Williams S, Oukil S, Liu VB, Miller JF.  (2011). PLoS Genet, 7(12), 31002414.

Modification to the Hemagglutinin Cleavage Site Control the Virulence of a Neurotropic H1N1 Influenza Virus. Sun X, Tse LV, Ferguson AD, Whittaker GR. (2010). J Virol, 84(17), 8683-90.

Diversity-Generating Retroelement Homing Regenerates Target Sequences for Repeated Rounds of Codon Rewriting and Protein Diversification. Guo H, Tse LV, Barbalat R, Sivaamnuaiphorn S, Xu M, Doulatov S, Miller JF. (2008). Mol Cell, 31(6), 813-23.

Education