Steven Meshnick

 
Professor
Epidemiology

Curriculum Vitae
REACH NC (Collexis) Research Profile

  3301 Michael Hooker Research Center , Department of Epidemiology
Campus Box 7435
Chapel Hill 27599-7435
USA
T: 919-966-7414


meshnick@email.unc.edu


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Education
1972 Columbia College, New York BA, Biological Chemistry
1978 Cornell University, New York MD, Medicine
1979 Rockefeller University, New York PhD, Medical biochemistry
 
 
 
Research activities

Steve Meshnick’s research group has four main areas of interest:

  1. Malaria in pregnancy. Studies are underway using molecular tools to understand how malaria causes poor birth outcomes. Efforts are also being made to develop new ways to protect pregnant women against malaria.
  2. Using molecular tools to improve infectious disease surveillance. High-throughput PCR methods are being applied to understand the epidemiology and evolution of malaria, antimalarial drug resistance and HIV in the Democratic Republic of the Congo. Learn about the Research and Innovation Solutions (RIS) Gillings Innovation Lab.
  3. The molecular epidemiology of drug resistance in Pneumocystis carinii Pneumonia. Markers for drug resistance have been identified and are now being validated in studies in the US and many other countries
  4. The epidemiology and ecology of tick-borne diseases in North Carolina. We are studying the effectiveness of long-lasting insecticide-impregnated uniforms in protecting outdoor workers from tick exposure
 
 
Key publications
Wongsrichanalai C, Pickard A, Wernsdorfer WH, et al. (2002)
Epidemiology of drug-resistant malaria..
Lancet Inf Dis: vol.2, p.209-18.

Alvarez-Martínez, M.J., Moreno, A. Miro, J.M., Eugenia Valls, M., Rivas, P.V., de Lazzari, E., Sued, O., Benito, N., Domingo, P., Ribera, E., Santin, M., Sirera, G., Segura, F., Vidal, F., Rodriguez, F., Riera, M., Cordero, M.E., Arribas, J.R., Jimenz de Anta, M.T., Gatell, J.M., Wilson, P.E., (2008)
Prevalence of Pneumocystis jirovecii DHPS Mutations and Their Influence on P. jirovecii Pneumonia Survival in Spanish HIV-Infected Patients in the Combined Antiretroviral Therapy Era..
Diagn Micro. Inf. Dis.: vol.62, p.34–43.

Taylor, S.M., Juliano, J.J., Trottman, P.A., Griffin, J.B., Landis, S.H., Kitsa, P., Tshefu, A.K., Meshnick, S.R. (2010)
High-throughput pooling and real-time PCR-based strategy for malaria detection..
J. Clin Micro: vol.48, p.512-9.

Juliano, J.J., Gadalla, N., Sutherland, C.J., and Meshnick, S.R (2010)
The Perils of PCR: Misclassification of antimalarial drug trial outcomes.
Trends Parasitol.: vol.26, p.119-24. Rogerson, S.J., Wijesinghe, R., and Meshnick, S.R. (2010)
Immunity as a determinant of treatment outcome in malaria.
Lancet Inf Dis: vol.10, p.51-59.