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Aims:
1. Identify whether obesity interacts with post-pregnancy changes in microenvironment to promote carcinogenesis using mouse models of basal-like breast cancer.
2. Identify changes induced by cell-cell communication between obese microenvironment and basal-like breast cancer using co-cultures.
3. Evaluate whether the phenotypic and gene expression markers induced by parity and obesity in experimental systems are also altered in the microenvironment of basal-like breast tumors in patients.