To provide brief descriptions of BCERP research to community-based audiences, BCERP staff have written lay abstracts of select publications.

Sundaram S, Freemerman AJ, Galanko JA, McNaughton KK, Bendt KM, Darr DB, Troester MA, Makowski, L. Obesity-mediated regulation of HGF/c-Met is associated with reduced basal-like breast cancer latency in parous mice. PLoS ONE. 2014 Oct 29; 9(10): e111394. doi: 10.1371/journal.pone.0111394.

Sundaram S, Le TL, Essaid L, Freemerman AJ, Huang MJ, Galanko JA, McNaughton KK, Bendt KM, Darr DB, Troester MA, Makowski L. Weight loss reversed obesity-induced HGF/c-Met pathway and basal-like breast cancer progression. Front Oncol. 2014 Jul 8; (175)4: doi: 10.3389/fonc.2014.00175.

Sundaram S, Freemerman AJ, Johnson AR, Milner JJ, McNaughton KK, Galanko JA, Bendt KM, Darr DB, Perou CM, Troester MA, Makowski L. Role of HGF in obesity-associated tumorigenesis: C3(1)-TAg mice as a model for human basal-like breast cancer. Breast Cancer Res Treat. 2013 Nov 12. [Epub ahead of print].

Razzaghi H, Troester MA, Gierach GL, Olshan AF, Yankaskas BC, Millikan RC. Mammographic Density and Breast Cancer Risk in White and African American Women. Breast Cancer Res Treat. 2012 Aug 3. [Epub ahead of print].

Pirone JR, D’arcy M, Stewart DA, Hines WC, Johnson M, Gould MN, Paul Y, Jerry DJ, Schneider SS, Troester MA. Age-Associated Gene Expression in Normal Breast Tissue Mirrors Qualitative Age-at-Incidence Patterns for Breast Cancer. Cancer Epidemiol Biomarkers Prev. 2012 Aug 2. [Epub ahead of print].

Fleming JM., Miller TC., Kidacki M, Ginsburg, Stuelten CH., Stewart DA., Troester MA., Vonderhaar, BK. Paracrine Interactions between Primary Human Macrophages and Human Fibroblasts Enhance Murine Mammary Gland Humanization in vivo. Breast Cancer Res. 2012 Jun 25;14(3):R97.

Stewart DA, Yang Y, Makowski L, Troester MA. Basal-like Breast Cancer Cells Induce Phenotypic and Genomic Changes in Macrophages. Mol Cancer Res. 2012 Jun;10(6):727-38.

Román-Pérez E, Casbas-Hernández P, Pirone JR, Rein J, Carey LA, Lubet RA, Mani SA, Amos KD, and Troester MA. Gene Expression in Extratumoral Microenvironment Predicts Clinical Outcome in Breast Cancer Patients. Breast Cancer Res. 2012 Mar 19;14(2):R51.

Sun X, Casbas-Hernandez P, Bigelow C, Makowski L, Jerry DJ, Schneider SS, Troester MA. Normal Breast Tissue of Obese Women is Enriched For Macrophage Markers And Macrophage-Associated Gene Expression. Breast Cancer Res Treat. 2012 Feb;131(3):1003-12.

Sampey BP, Vanhoose AM, Winfield H, Freemerman AJ, Muehlbauer M, Fueger PT, Newgard CB, and Makowski L. Cafeteria-Diet is a Robust Model of Human Metabolic Syndrome with Liver and Adipose Inflammation: Comparison to High Fat Diet. Obesity (Silver Spring). 2011 Jun;19(6):1109-17.

Sampey BP, Lewis TD; Barbier CS, Makowski L, Kaufman DG. Genistein Effects on Stromal Cells Determines Epithelial Proliferation in Endometrial Co-Cultures. Exp Mol Pathol. 2011 Jun;90(3):257-63. Camp, JT, Elloumi, F, Roman-Perez, E, Rein, J, Stewart, DA, Harrell, JC, Perou, CM, Troester, MA. Interactions with fibroblasts are distinct in Basal-like and luminal breast cancers. Mol Cancer Res. 2011 Jan;9(1):3-13.

CONTACT INFORMATION
UNC BCERP Principal Investigator: Melissa Troester
Funding provided by NIEHS Grant # U01 ES019472-01

135 Dauer Drive
CB #7435
Chapel Hill 27599-7435
(919) 966-7408