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UNC Nutrition Obesity Research Center (NORC)
Nutritional Genomics
and Microbiome Core

About

Researcher prepares samples for analysis.

Researcher prepares samples for analysis.

The Nutritional Genomics and Microbiome Core is an all-encompassing support system for investigators conducting research on nutrigenetic and microbiome aspects of obesity and obesity-related diseases.

The goal for some obesity research is to identify genetic and environmental factors and interactions that affect an individual’s susceptibility and to identify high-utility targets for prevention and treatment. In the long run, investigators should be able to individualize or personalize diet and health recommendations based on the knowledge gained from prior research conducted on obesity. Thus, there is a great need for studies with strong translational potential. Additionally, the core’s microbiome services provide assistance with experimental design, grant writing, data interpretation, and manuscript development for nutrition/obesity-focused microbiome studies.


Researcher uses the AnaPrep 12 to extract DNA.

Researcher uses the AnaPrep 12 to extract DNA.

Services

The Nutritional Genomics and Microbiome Core offers a variety of services. To learn more about a specific service and/or to submit a service request, visit us on iLab.

  • Basic Lab Analysis
  • DNA/RNA extractions: isolate DNA/RNA from blood, saliva, tissue, or blood spots to analyze SNPs
  • Concentrating DNA samples, PCR runs, gels
  • Data Cleaning/Mining; Interpretation of Results; Tabulation and Graphical Representation of Results
  • One-Carbon Metabolism SNP Chip Microarray: One-Carbon Metabolism SNP Chip Microarray: This is the MEGAEX microarray (illumina) containing over 2 million human SNPs including many related to one-carbon metabolism, (e.g.: PEMT rs12325817, CHDH rs12676 and CHDH rs9001).
  • Variant Identification and Annotation
  • Genome-Wide Linkage Analysis
  • Multipoint Identity by Descent (MIBD) Determination
  • Genome-Wide SNP or Whole Genome Sequence Association Analysis, Genome-Wide Transcriptional Data Analysis
  • Haplotype Inference, Genotype and Phenotype Imputation
  • Nutrigenetics and Nutrigenomics Data Analysis/Consulting
  • Proofreading of Manuscript/Grant Proposals; Imputation; Estimation of Kinships and Pedigrees in Related Samples
  • Grant Development Assistance
  • Initial Grant Review CH Microbiome
  • Calorimetry
  • Microbiome Data Analysis/Consulting NRI Microbiome
  • DNA Extraction and RNA Extraction Microbiome: isolate DNA/RNA from stool samples
  • Microbiome Data Analysis/Consulting

Contact Us

Saroja Voruganti

Dr. Saroja Voruganti

Saroja Voruganti, PhD
Assistant Professor, Nutrition
500 Laureate Way, Suite 3150
Kannapolis, NC 28081
(704) 250-5009
saroja@unc.edu

  • Director, Nutritional Genomics and Microbiome Core (Nutrigenetics)

Ian Carroll

Dr. Ian Carroll

Ian Carroll, PhD
Assistant Professor, Nutrition
111 Mason Farm Road , 7312C MBRB Building
CB# 7032
Chapel Hill, NC 27599
(919) 843-4893
ian_carroll@med.unc.edu

  • Co-Director, Nutritional Genomics and Microbiome Core (Microbiome Analysis)

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