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UNC Nutrition Obesity Research Center (NORC)
Metabolomics and Metabolic Molecular Phenotyping Core
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The Metabolomics and Metabolic Molecular Phenotyping Core provides cutting edge nutritional metabolomics services, biochemistry methods and molecular biology techniques for nutrition research.


The goals of our Core are to encourage and facilitate the use of biomarkers for nutritional epidemiological and intervention studies, to provide access to state-of-the-art techniques and equipment to bench scientists, and to provide cost-effective assays for investigators without lab facilities. The Core also provides training for students and postdoctoral fellows. This Core is split between two locations, one at Chapel Hill and one at Kannapolis. This way we are able to provide a wide array of instrumentation and support investigators at either location.

Additionally, metabolomics, the profiling of the many small molecules in blood, urine or tissues, provides an opportunity for investigators to obtain a snapshot of metabolism. The metabolomics lab, located in Kannapolis, NC, is working to make personalized medicine a reality through metabolomics. Metabolomic analyses provide a more comprehensive view of a patient’s metabolism than the limited measurements of glucose and cholesterol that doctors employ today. Using metabolomics, the lab assesses differences in the metabolic profile of individuals that correlate with states of wellness or disease.


Services

Please visit our online site to order and learn more about our services.

  • Aperio ScanScope CS Digital Slide Scanner
  • Aqueous Choline Metabolites
  • Atomic Absorption Spectrometry
  • Choline Metabolites
  • Consultation (Nutritional Biochemistry & Molecular Biology)
  • Cytokines & Adipokines
  • Dimethyl-glycine, Choline, and Betaine
  • Drug Abuse Tests
  • FACS Aria III Training
  • Flow Cytometry
  • Fluorescence Activated Cell Sorting
  • Folate Assay (Food or Tissue)
  • Folate Assay (RBC or Plasma)
  • Inflammation (ELISA or RIA)
  • Lipids & Lipid Proteins
  • Methods Development
  • Nutrients
  • Organic Choline Metabolites
  • Other Assays
  • Oxidative Stress
  • PCR, RT-PCR & qRT-PCR
  • Peptide Hormones
  • Phospholipid Fatty Acids
  • Plasma, Serum, & Lymphocytes Separation
  • Protein Estimation by BCA Method
  • RNA Isolation & Purification
  • TMA (TMAO, choline, betaine, creatinine)
  • Use of the Aria III Fluorescence Activated Cell Sorter
  • Zeiss Axio Imager A1 Fluorescence Microscope with Camera (DIY)

Contact Us

Susan Sumner, PhD Professor, Nutrition 500 Laureate Way Suite 4201 Kannapolis, NC 28081 (704) 250-5066 susan_sumner@unc.edu
  • Director, Metabolomics and Metabolic Molecular Phenotyping Core
Melinda Beck, PhD Associate Chair for Academics and Professor, Nutrition 2303 Michael Hooker Research Center CB# 7461 Chapel Hill, NC 27599 (919) 966-6809 melinda_beck@unc.edu
  • Co-Director, Metabolic Molecular Phenotyping Core-Chapel Hill
Steven Zeisel, MD, PhD Kenan Distinguished Professor, Nutrition and Pediatrics 2115-A Michael Hooker Research Center CB# 7461 Chapel Hill, NC 27599 (919) 843-4731 steven_zeisel@unc.edu
  • Co-Director, Metabolic Molecular Phenotyping Core-Kannapolis
Mirek Styblo, PhD Professor, Nutrition Adjunct Associate Professor, Environmental Sciences and Engineering 2302 Michael Hooker Research Center CB# 7461 Chapel Hill, NC 27599 (919) 966-5721 styblo@med.unc.edu
  • Director, Atomic Absorption Spectrometry Lab
Susan McRitchie Program Manager, Sumner Lab 500 Laureate Way Kannapolis, NC 28081 (704) 250-5067 susan_mcritchie@unc.edu
  • Core Manager, Metabolomics and Metabolic Molecular Phenotyping Core
Steve Orena Lab Manager, Zeisel Lab 500 Laureate Way Suite 2148 Kannapolis, NC 28081 (704) 250-5041 stephen_orena@unc.edu
  • Core Manager, Metabolic Molecular Phenotyping Core-Kannapolis
  • Contact for all questions regarding the Core and/or services in Kannapolis
Qing Shi, MS Research Technician 2215 Michael Hooker Research Center CB# 7461 Chapel Hill, NC 27599 (919) 966-7162 qing_shi@unc.edu
  • Core Manager, Metabolic Molecular Phenotyping Sub-Core-Chapel Hill
  • Contact for all questions regarding the Core and/or services in Chapel Hill