Metabolomics and Metabolic Molecular Phenotyping Core

norc-slide1

The Metabolomics and Metabolic Molecular Phenotyping Core provides cutting edge nutritional metabolomics services, biochemistry methods and molecular biology techniques for nutrition research.


The goals of our Core are to encourage and facilitate the use of biomarkers for nutritional epidemiological and intervention studies, to provide access to state-of-the-art techniques and equipment to bench scientists, and to provide cost-effective assays for investigators without lab facilities. The Core also provides training for students and postdoctoral fellows. This Core is split between two locations, one at Chapel Hill and one at Kannapolis. This way we are able to provide a wide array of instrumentation and support investigators at either location.

Additionally, metabolomics, the profiling of the many small molecules in blood, urine or tissues, provides an opportunity for investigators to obtain a snapshot of metabolism. The metabolomics lab, located in Kannapolis, NC, is to working to make personalized medicine a reality through metabolomics. Metabolomic analyses provide a more comprehensive view of a patient’s metabolism than the limited measurements of glucose and cholesterol that doctors employ today. Using metabolomics, the lab assesses differences in the metabolic profile of individuals that correlate with states of wellness or disease.


Services

Please visit our online site to order and learn more about our services.

  • Aperio ScanScope CS Digital Slide Scanner
  • Aqueous Choline Metabolites
  • Atomic Absorption Spectrometry
  • Choline Metabolites
  • Consultation (Nutritional Biochemistry & Molecular Biology)
  • Cytokines & Adipokines
  • Dimethyl-glycine, Choline, and Betaine
  • Drug Abuse Tests
  • FACS Aria III Training
  • Flow Cytometry
  • Fluorescence Activated Cell Sorting
  • Folate Assay (Food or Tissue)
  • Folate Assay (RBC or Plasma)
  • Inflammation (ELISA or RIA)
  • Lipids & Lipid Proteins
  • Methods Development
  • Nutrients
  • Organic Choline Metabolites
  • Other Assays
  • Oxidative Stress
  • PCR, RT-PCR & qRT-PCR
  • Peptide Hormones
  • Phospholipid Fatty Acids
  • Plasma, Serum, & Lymphocytes Separation
  • Protein Estimation by BCA Method
  • RNA Isolation & Purification
  • TMA (TMAO, choline, betaine, creatinine)
  • Use of the Aria III Fluorescence Activated Cell Sorter
  • Zeiss Axio Imager A1 Fluorescence Microscope with Camera (DIY)

Contact Us

Susan Sumner, PhD
Professor, Nutrition
500 Laureate Way
Suite 4201
Kannapolis, NC 28081
(704) 250-5066
susan_sumner@unc.edu

  • Director, Metabolomics and Metabolic Molecular Phenotyping Core

Melinda Beck, PhD
Associate Chair for Academics and Professor, Nutrition
2303 Michael Hooker Research Center
CB# 7461
Chapel Hill, NC 27599
(919) 966-6809
melinda_beck@unc.edu

  • Co-Director, Metabolic Molecular Phenotyping Core-Chapel Hill

Steven Zeisel, MD, PhD
Kenan Distinguished Professor, Nutrition and Pediatrics
2115-A Michael Hooker Research Center
CB# 7461
Chapel Hill, NC 27599
(919) 843-4731
steven_zeisel@unc.edu

  • Co-Director, Metabolic Molecular Phenotyping Core-Kannapolis

Mirek Styblo, PhD
Professor, Nutrition
Adjunct Associate Professor, Environmental Sciences and Engineering
2302 Michael Hooker Research Center
CB# 7461
Chapel Hill, NC 27599
(919) 966-5721
styblo@med.unc.edu

  • Director, Atomic Absorption Spectrometry Lab

Susan McRitchie
Program Manager, Sumner Lab
500 Laureate Way
Kannapolis, NC 28081
(704) 250-5067
susan_mcritchie@unc.edu

  • Core Manager, Metabolomics and Metabolic Molecular Phenotyping Core

Steve Orena
Lab Manager, Zeisel Lab
500 Laureate Way
Suite 2148
Kannapolis, NC 28081
(704) 250-5041
stephen_orena@unc.edu

  • Core Manager, Metabolic Molecular Phenotyping Core-Kannapolis
  • Contact for all questions regarding the Core and/or services in Kannapolis

Qing Shi, MS
Research Technician
2215 Michael Hooker Research Center
CB# 7461
Chapel Hill, NC 27599
(919) 966-7162
qing_shi@unc.edu

  • Core Manager, Metabolic Molecular Phenotyping Sub-Core-Chapel Hill
  • Contact for all questions regarding the Core and/or services in Chapel Hill