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Delivery of biomolecules to the mammalian gut using engineered probiotic Saccharomyces boulardii

February 20, 2020 @ 4:30 pm - 5:30 pm

Flyer for Nathan Crook lectureDr. Nathan Crook’s research focuses on developing new methods for engineering microbes, and applying these methods to improve human health. As a graduate student at UT Austin, he developed several new methods to genetically engineer baker’s yeast, including RNAi screens and continuous directed evolution approaches using retrotransposons. Dr. Crook also developed model-based approaches for yeast engineering, encompassing the strengthening of yeast promoters via nucleosome exclusion and enhancing translation rate via removal of mRNA secondary structure. As a postdoc at Washington University in Saint Louis, he explored the evolutionary trajectories of probiotic E. coli Nissle in the mammalian gut, including genomic mutations and horizontally transferred genes. As a new assistant professor at NC State, Dr. Crook’s lab combines his training in metabolic engineering and gut microbial ecology to engineer probiotic yeast (S. boulardii) to secrete drug molecules in the gut.

For more information, contact Amy Smither.

Details

Date:
February 20, 2020
Time:
4:30 pm - 5:30 pm
Event Categories:
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