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BIOS Seminar: The sps3 experience

February 14 @ 3:30 pm - 4:30 pm

Leslie McClure, PhD, professor and chair of epidemiology and biostatistics at Drexel University’s Dornsife School of Public Health, will present “A Post-Hoc Evaluation of a Sample Size Re-estimation: The SPS3 Experience,”

Methodologically, Dr. McClure is interested in the design and analysis of randomized clinical trials with multiple outcomes, and methodology for re-estimating sample size in on-going randomized trials. She is the principle investigator for the Coordinating Center for the CDC-sponsored Diabetes LEAD (Location, Environmental Attributes, and Disparities) Network, with a primary goal of furthering our understanding of the role of community-level factors and geographic differences in diabetes incidence and prevalence across the US and across demographic groups.

Abstract:

The use of adaptive designs has been increasing in randomized clinical trials. Sample size re-estimation is a type of adaptation in which nuisance parameters are estimated at an interim point in the trial and the sample size re-computed based on these estimates. However, post-hoc evaluations of adaptations, including sample size re-estimations, have not
frequently been performed, leaving questions about the gains that come from utilizing these procedures in practice. In this talk, I describe the statistical impact of implementing a sample size re-estimation in the Secondary Prevention of Small Subcortical Strokes (SPS3) study and describe the effect of the adaptation on the practical aspects of the study.

Details

Date:
February 14
Time:
3:30 pm - 4:30 pm
Event Categories:
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Location

Blue Cross and Blue Shield Auditorium (0001 Michael Hooker Research Center)
Michael Hooker Research Center
Chapel Hill, NC 27516 United States
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Website:
https://sph.unc.edu/iis/mhrc-0001/