Genetic Epidemiology Research
Overview
Genetic Epidemiology is the study of genetic factors that independently or in combination with environmental factors influences the risk of disease. Genetic epidemiology uses a variety of study designs including family and population approaches to investigate disease risk. Departmental faculty use the methods of genetic epidemiology to investigate genetic susceptibility and gene-environment interaction in relation to cancer, cardiovascular disease, reproductive and pediatric disease, and other health conditions.
Core Faculty
Dr. Christy Avery: Genetic variants associated with complex diseases; Adverse drug reactions; Genome-wide association studies.
Dr. Jeannette Bensen: Breast cancer susceptibility; Racial differences in prostate cancer; Birth defects etiology and prevention; Cancer survivors.
Dr. Kimon Divaris: Genetics of oral and dental traits; dental caries; periodontal disease; gene-environment interactions; genome-wide association studies; gene-centric and pathway analyses; trans-ethnic studies; health disparities; qualitative studies
Dr. Nora Franceschini: Genetics of chronic kidney disease and blood pressure in diverse populations.
Dr. Misa Graff: Genetic variants associated with complex diseases.
Dr. Kari North: Genetic epidemiology of complex traits and obesity; research that takes place at the intersection of human genetics, epidemiology, statistical techniques and interdisciplinary translational research.
Dr. Til Stürmer: Adverse drug reactions; Genome-wide association studies.
Dr. Eric Whitzel: Adverse drug reactions; Genome-wide association studies.
Dr. Kristin Young: Genetic variants associated with complex diseases.
Affiliated genetic epidemiology faculty are involved in a number of diverse research projects, a number of which are listed below. Other genetic and molecular epidemiology projects can be found in faculty and program research profiles.
Selected Research Projects
- Analytic laboratory for development of biomarkers of environmental exposure to arsenic
- Carolina Breast Cancer Study
- Comprehensive Mapping of a Blood Pressure QTL on Chromosome 17
- Dietary Fiber, Gut Microflora, & Epigenetic Events that Prevent Colorectal Cancer
- Environmental arsenic and diabetes mellitus
- Gene Modifiers in CF Liver Disease
- Gene-Environment Interactions and Weight Gain
- Genes Environment and Melanoma Study
- Genetic and Environmental Determinants of Obesity and Cardiovascular Risk across the Lifecourse: The Santiago Longitudinal Cohort Study
- Genetic Epidemiology of Metabolic Diseases of Obesity
- Genome Wide Association Study of Breast Cancer in African Americans
- Genome-Wide Association for Loci Influencing CVD and Other Heart, Lung and Blood Phenotypes
- Genome-Wide Association Study of Early Childhood Caries
- Health Care Access and Prostate Cancer Treatment in North Carolina: HCaP-NC
- Hispanic Community Health Study
- HyperGEN
- Innovative Analysis of Blood Pressure Variation in Gene-Environment Context
- NHGRI Genome Sequencing Program Coordinating Center
- North Carolina Center for Birth Defects Research and Prevention
- Pharmacogenomics of risk factors for cardiac arrhythmias in global populations
- Population Architecture Using Genomics and Epidemiology (PAGE) Phase II – Study Investigators CALiCo II
- Prospective meta-analysis of drug-gene interactions: CHARGE GWAS consortium
- Prostate Cancer Susceptibility: The ICPCG Stdy
- QTL mapping for genes regulating apoptosis capacity
- Racial Differences in Prostate Cancer: Influence of Health Care and Host and Tumor Biology (PCaP)
- Strong Heart Family Study
- The Human Life Course and the Biodemography of Aging
- UNC Health Registry
- Women’s’ Health Initiative SHARE GWAS Analysis Center
