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Center for Environmental Health and Susceptibility
UNC Center for Environmental Health and Susceptibility

NEW – 2019-2020 Pilot Project Grants Available!

2019-2020 CEHS Pilot Project Application Guidelines
Letter of Intent Due November 30, 2018 – Application due January 22, 2019

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Facilitating Environmental Exposure Research

Creating research collaborations and encouraging new environmental exposure researchers can advance environmental health sciences. The UNC Center for Environmental Health and Susceptibility facilitates these collaborations by funding university infrastructure to support scientific equipment, facilities, and other resources that can be shared among environmental health researchers. By pursuing shared research questions, CEHS can identify emerging issues that advance understanding about how pollutants and other environmental factors affect human biology and may lead to disease.  The Center is funded through a P-30 grant from the National Institutes of Environmental Health Sciences.

Message from the Director

Dr. Melissa Troester
Dr. Melissa Troester, Director
"The Center for Environmental Health and Susceptibility (CEHS) is part of one of the most critical public health efforts in history, investigating environmental exposures and their effects on human health." Read more.

Research Highlight

Reproductive Toxicology, March 2018

Intergenerational response to the endocrine disruptor vinclozolin is influenced by maternal genotype and crossing scheme.

Folami Ideraabdullah, PhD, Assistant Professor
Genetics and Nutritional Research Institute, UNC-CH

In utero exposure to vinclozolin (VIN), an antiandrogenic fungicide, is linked to multigenerational phenotypic and epigenetic effects. Mechanisms remain unclear. We assessed the role of antiandrogenic activity and DNA sequence context by comparing effects of VIN vs. M2 (metabolite with greater antiandrogenic activity) and wild-type C57BL/6 (B6) mice vs. mice carrying mutations at the previously reported VIN-responsive H19/Igf2 locus. Findings demonstrate that maternal effects and crossing scheme play a major role in multigenerational response to in utero exposures.

Link to PubMed article
2018 Mar 10;78:9-19. doi: 10.1016/j.reprotox.2018.03.005. [Epub ahead of print]

 

Outreach Highlight

Preventing Lead Poisoning online module now LIVE

Learn about the main causes of lead exposure and poisoning, testing recommendations for children, and prevention methods.

This training was produced in partnership with the North Carolina Lead Poisoning Prevention Program and the North Carolina Institute for Public Health. This module is one of a series of Healthy Homes training modules under development.

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