UNC Center for Environmental Health and Susceptibility
Facilitating Environmental Exposure Research
Creating research collaborations and encouraging new environmental exposure researchers can advance environmental health sciences. The UNC Center for Environmental Health and Susceptibility facilitates these collaborations by funding university infrastructure to support scientific equipment, facilities, and other resources that can be shared among environmental health researchers. By pursuing shared research questions, CEHS can identify emerging issues that advance understanding about how pollutants and other environmental factors affect human biology and may lead to disease. The Center is funded through a P-30 grant from the National Institutes of Environmental Health Sciences.
Reproductive Toxicology, March 2018
Intergenerational response to the endocrine disruptor vinclozolin is influenced by maternal genotype and crossing scheme.
Folami Ideraabdullah, PhD, Assistant Professor
Genetics and Nutritional Research Institute, UNC-CH
In utero exposure to vinclozolin (VIN), an antiandrogenic fungicide, is linked to multigenerational phenotypic and epigenetic effects. Mechanisms remain unclear. We assessed the role of antiandrogenic activity and DNA sequence context by comparing effects of VIN vs. M2 (metabolite with greater antiandrogenic activity) and wild-type C57BL/6 (B6) mice vs. mice carrying mutations at the previously reported VIN-responsive H19/Igf2 locus. Findings demonstrate that maternal effects and crossing scheme play a major role in multigenerational response to in utero exposures.
Learn about the main causes of lead exposure and poisoning, testing recommendations for children, and prevention methods.
This training was produced in partnership with the North Carolina Lead Poisoning Prevention Program and the North Carolina Institute for Public Health. This module is one of a series of Healthy Homes training modules under development.