Yuchao Jiang

Yuchao Jiang, PhD

Associate Professor
Department of Biostatistics
Assistant Professor
Department of Genetics
4115D McGavran-Greenberg Hall
CB# 7420
Chapel Hill, NC 27599-7420


Dr. Yuchao Jiang is an assistant professor in the Department of Biostatistics and the Department of Genetics at UNC. He is also a member of the Lineberger Comprehensive Cancer Center.

The Jiang Lab’s primary research interests lie in statistical modeling, method development and data analysis in genetics and genomics. Current research is focused on developing statistical methods and computational algorithms to better utilize and analyze different types of next-generation sequencing data under various setting, with application to data from large-scale cohort studies of human health and disease. Special focus is on single-cell genomics, single-cell transcriptomics, single-cell epigenomics, copy number variation detection, tumor heterogeneity, cancer phylogeny, DNA damage and repair, and circadian rhythm detection.

Honors and Awards

Teaching Innovation Award
2020, Gillings School of Global Public Health, UNC Chapel Hill

Maximizing Investigators’ Research Award
2020, National Institute of General Medical Sciences

Computational Medicine Program Pilot Award
2019, The University of North Carolina at Chapel Hill

Developmental Award
2018, UNC Lineberger Comprehensive Cancer Center

Representative Courses

Introduction to Machine Learning (BIOS 635)

Statistical Methods for Gene Expression Analysis (BIOS 785)

Research Interests:

Computational Biology, Statistical Genetics, Statistical Genomics

Key Publications

SCOPE: a normalization and copy number estimation method for single-cell DNA sequencing. Wang R, Lin D, Jiang Y. (2020). Cell Systems, 10(5), 445-452.

Destin: toolkit for single-cell analysis of chromatin accessibility. Urrutia E., Chen L., Zhou H., and Jiang Y. (2019). Bioinformatics.

CODEX2: full-spectrum copy number variation detection by high-throughput DNA sequencing.  Jiang Y, Wang R, Urrutia E, Anastopoulos IN, Nathanson KL, Zhang NR.  (2018). Genome Biology, 19(1), 202.

Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs. Yimit A., Adebali O., Sancar A., and Jiang Y.  (2019). Nature Communications, 10(1).

SCALE: modeling allele-specific gene expression by single-cell RNA sequencing. Jiang Y, Zhang NR, Li M. (2017). Genome Biology, 18(1), 74.


  • PhD, Genomics and Computational Biology, University of Pennsylvania, Perelman School of Medicine, 2017
  • MA, Statistics, University of Pennsylvania, The Wharton School, 2014
  • BS, Computational Biology, Cornell University, 2012