Dr. Sergey Krupenko

Sergey A. Krupenko, PhD

Department of Nutrition
500 Laureate Way
Nutrition Research Institute
University of North Carolina
Kannapolis, NC 28081


Dr. Sergey A. Krupenko is a Professor of Nutrition who studies enzymes regulating folate metabolism.  

Sergey Krupenko in the Gillings News

Representative Courses

NUTR 868, Advance Nutrition Biochemistry: Nutrition and Cancer

Key Publications

Rho GTPases RhoA and Rac1 mediate effects of dietary folate on metastatic potential of A549 cancer cells through the control of cofilin phosphorylation. Oleinik NV, Helke KL, Kistner-Griffin E, Krupenko NI, Krupenko SA (2014). J Biol Chem., 289(38), 26383-94.
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JNK1/2 regulate Bid by direct phosphorylation at Thr59 in response to ALDH1L1. Prakasam A, Ghose S, Oleinik NV, Bethard JR, Peterson YK, Krupenko NI, Krupenko SA (2014). Cell Death Dis., 31(5), e1358.
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Epigenetic Silencing of ALDH1L1, a Metabolic Regulator of Cellular Proliferation, in Cancers. Oleinik NV, Krupenko NI, Krupenko SA (2011). Genes Cancer, 2(2), 130-9.
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Conserved catalytic residues of the ALDH1L1 aldehyde dehydrogenase domain control binding and discharging of the coenzyme. Tsybovsky Y, Krupenko SA (2011). J Biol Chem., 286(26), 23357-67.
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ALDH1L1 inhibits cell motility via dephosphorylation of cofilin by PP1 and PP2A. Oleinik NV, Krupenko NI, Krupenko SA (2010). Oncogene, 25(29), 6233-44.
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A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. Cahoy JD, Emery B, Kaushal A, Foo LC, Zamanian JL, Christopherson KS, Xing Y, Lubischer JL, Krieg PA, Krupenko SA, Thompson WJ, Barres BA (2008). J Neurosci., 28(1), 264-78.
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Cooperation between JNK1 and JNK2 in activation of p53 apoptotic pathway. Oleinik NV, Krupenko NI, Krupenko SA (2007). Oncogene, 26(51), 7222-30.
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  • B.S., Biochemistry, Byelorussian State University, Minsk, USSR, 1980
  • Degree of Candidate of Science in Biochemistry (equivalent to Ph.D.), Biochemistry, Institute of Bioorganic Chemistry Byelorussian Academy of Science, Minsk, USSR, 1987