Gillings School Directory

Paul Stewart, PhD

Paul Stewart

Paul Stewart, PhD

Department of Biostatistics
  • 3105G McGavran-Greenberg Hall
  • CB #7420
  • Chapel Hill, NC 27599
  • USA

Dr. Paul W. Stewart is a professor in the Department of Biostatistics. 

His expertise and interests in the development and application of statistical strategies and methods for design and analysis of biomedical studies are well-suited for biomedical research, collaboration, and consultation. Dr. Stewart has more than 35 years of experience in research design, statistical computation, interpretive analysis, collaboration with biomedical investigators, leadership of biostatistics core units for clinical studies, and service as chief biostatistician on the Scientific Review Subcommittee of the UNC School of Medicine IRB. For ten years, he directed both the Biostatistics Core of the General Clinical Research Center (GCRC) at UNC and the Biostatistics Core of the UNC Center for AIDS Research (CFAR). He also has experience directing a Collaborative Studies Coordinating Center unit for the NHLBI Multicenter DELTA Program and led biostatistics collaborations in an NHLBI Pediatric Pulmonary Specialized Center of Research. 

Dr. Stewart has 8 years of experience teaching a course on ‘Principles of Statistical Consulting and Collaboration’, and more than 10 years of experience teaching graduate courses in the advanced theory of linear statistical models and linear algebra in the UNC Department of Biostatistics.  

He has extensive experience in statistical consulting and collaboration with the US EPA and the pharmaceutical industry. He represents the Department of Biostatistics on the Conflict of Interest Committee of the UNC Gillings School of Global Public Health. For the journal Pediatric Pulmonology, Dr. Stewart serves as the Associate Editor for Research Design and Biostatistical Analysis. Dr. Stewart is the chief biostatistician on the UNC Scientific Review Committee in the Office of Clinical Trials.  

Honors and Awards

Scientific Achievement Award for Publication

1997, US-EPA

Associate Editor

Pediatric Pulmonology

NIH Training Grant

The Honor Society for Public Health Professionals

Faculty Award

Delta Omega

Teaching Interests

Dr. Stewart has taught:

- BIOS 107 Matrix Theory / Linear Algebra

- BIOS 762 Advanced Linear Models I

- BIOS 841 Principles of Statistical Consulting and Collaboration

- BIOS 842 Practice in Statistical Consulting

- BIOS 992 Master's Thesis

- BIOS 994 Doctoral Disertation

Dr. Stewart's experience in teaching has been in a variety of settings within and apart from the School of Public Health. Much of his experience has occurred in the process of training and supervising a large number of students of biostatistics who have worked with Dr. Stewart on collaborative biomedical research projects as graduate research assistants (GRAs). This activity has involved thousands of hours of direct, practical training and instruction in statistical strategies and methods, statistical computing, research database management, consulting skills, and scientific writing. In addition, Dr. Stewart has directed the thesis research of students of biostatistics and has served as an active member of other thesis committees. Dr. Stewart has also provided tutorials and seminars to groups and clients in the Schools of Medicine, Pharmacy, Dentistry, Nursing, and Public Health and to other groups within and apart from the UNC system.

Research Activities

Linear / non-linear / generalized linear / tree-structured models, Design and analysis of clinical trials and observational studies, Analysis strategies and methods for correlated responses, Analysis of incomplete / censored / coursened data, Causal inference, Pulmonology, Cardio-metabolic research, Pharmacology research, Infectious diseases research, Cancer biology, Ecological and environmental research.  

Service Activities

Referee of submitted articles for the following journals:
American Statistician
Pediatric Pulmonology
Statistics & Computing
Environmental Statistics
Journal of Dental Research
American Journal of Respiratory and Critical Care Medicine

Member of the following professional societies:
American Statistical Association (ASA)
Publication Officer of the ASA Section on Statistical Consulting (2007 and 2008) International Biometric Society
Association of GCRC and CTSA Statisticians (
Founder (2002) and member of the Association of CFAR Statisticians (

Key Publications

A comprehensive assessment of patient reported symptom burden, medical comorbidities, and functional well-being in patients initiating direct acting antiviral therapy for chronic hepatitis C --Results from a large US multi-center observational study. Evon DM, Stewart PW, Amador J, Serper M, Lok AS, Sterling RK, Sarkar S, Golin CE, Reeve BB, Nelson DR, Reau N, Lim JK, Reddy R, Di Bisceglie AM, Fried MW (2018). PLOS ONE, 3(8), 1-18.

Recommendations for planning pilot studies in clinical and translational research. Moore CG, Carter R, Nietert PJ, Stewart PW (2011). Clin Transl Sci, 4(5), 332-337.

Line-segment confidence bands for repeated measures. Stewart PW (1987). Biometrics, 43.

An experimental approach to evaluate the impact of impaired transport function on hepatobiliary drug disposition using Mrp2-deficient TR- rat sandwich-cultured hepatocytes in combination with Bcrp knockdown. Kim Brouwer, Rhiannon Hardwick, Nathan Pfeifer, Paul Stewart, Kyunghee Yang, Wei Yue (2014). Molecular Pharmaceutics, 11(3), 766-775.

Cantharidin for the treatment of molluscum contagiosum: A prospective, double-blinded, placebo-controlled trial. Jacquelyn Dosal, Ja-An Lin, Dean Morrell, Paul Stewart, Christianna Williams (2014). Pediatric Dermatology, 31(4), 440-449.

Correction to "The influence of sex, ethnicity, and CYP2B6 genotype on bupropion metabolism as an index of hepatic CYP2B6 activity in humans" (Drug Metabolism & Disposition (2013) 41 (575-581) DOI: 10.1124/dmd.112. 048108). M.L. Chen, R.L. Hawke, J.H. Hull, K. IIic, A.D. Kashuba, C.M. Lindley, E.G. Schuetz, P.W. Stewart, R.K. Thirumaran (2014). Drug Metabolism and Disposition, 42(7), 1137-.

Monthly haemostatic factor variability in women and men. Patricia Elmer, Abby Ershow, Mark Fung, Henry Ginsberg, Alison Hill, Stephen Holleran, Penny Kris-Etherton, Michael Lefevre, Thomas Pearson, Roberta Reed, Paul Stewart, Russell Tracy (2014). European Journal of Clinical Investigation, 44(3), 309-318.

Staff/Administrative Duties

2020-Present Member SPH Conflict of Interest Committee

1992-2006 Chairman Biostatistics Information Technology

2003-2003 Chairman Committee on Continuation of Business / Emergency Response

1991-1991 Chairman Biostatistics Seminar Committee

1990-1991 Advisor Biostatistics Advisory Committee on Information Technology

1989-1997 Member Biostatistics Seminar Committee

1985-1991 Member Examinations Committee

1982-1992 Member Statistical Computing and Data Management Committee

1985-1986 Member Linear Models Courses Committee (ad hoc)

1994-1995 Member SPH Dean's Computer & Data Processing Advisory Committee

1996-1996 Member SPH Dean's Committee for Review of Information Technology


PhD, Biostatistics, University of North Carolina at Chapel Hill, 1981

MS, Statistics, University of North Carolina at Chapel Hill, 1977

BS, Mathematics, Furman University, 1975

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