Nora Franceschini, MD, MPH

Research Associate Professor Department of Epidemiology

T:(919) 966-1305

noraf@unc.edu

137 East Franklin Street, Suite 306

CB #8050

Chapel Hill, NC 27514

USA

Nora Franceschini is a nephrology-trained physician and a cardiovascular disease epidemiologist. Her research focuses on environmental and genetic determinants of hypertension, kidney and cardiovascular diseases in diverse and underrepresented U.S. minority populations who carry a high burden of chronic health conditions. This work includes gene discovery in American Indians, African Americans and Hispanics/Latinos, trans-ethnic genetic studies, and studies to characterize the social/environmental context in which genetic variants contribute to health conditions.

Honors and Awards

UNC Postdoctoral Award for Research Excellence
2006, UNC-CH

GSK Center for Excellence in Pharmacoepidemiology Fellowship Award
2005, UNC-CH

Representative Courses

EPID 799A: Epidemiology of Kidney Disease

Research Activities

Epidemiology of Kidney and Cardiovascular Disease
Genetics of Hypertension and Kidney Traits in Diverse Populations
Genetics of Subclinical Atherosclerosis and Cardiovascular Disease Risk Factors
Gene-Environment Interaction of Heavy Metals on Cardiovascular Disease Outcomes
Genetics of Reproductive Traits

Service Activities

Dr. Franceschini volunteers on the National Kidney Foundation Kidney Health Risk Assessment and Early Evaluation Programs in North Carolina.

Key Publications

Adiposity Patterns and the Risk for ESRD in Postmenopausal Women. Franceschini N, Gouskova NA, Reiner AP, Bostom A, Howard BV, Pettinger M, Umans JG, Brookhart MA, Winkelmayer WC, Eaton CB, Heiss G, Fine JP.  (2015). Clinical journal of the American Society of Nephrology : CJASN, 10(2), 241-50.

Generalization of associations of kidney-related genetic loci to American Indians. Franceschini N, Haack K, Almasy L, Laston S, Lee ET, Best LG, Fabsitz RR, MacCluer JW, Howard BV, Umans JG, Cole SA (2014). Clinical Journal of the American Society of Nephrology, 9(1), 150-158.

Genome-wide association analysis of blood-pressure traits in african-ancestry individuals reveals common associated genes in african and non-african populations. Franceschini N, Fox E, Zhang Z, Edwards TL, Nalls MA, Sung YJ, Tayo BO, Sun YV, Gottesman O, Adeyemo A, Johnson AD, Young JH, Rice K, Duan Q, Chen F, Li Y, Tang H, Fornage M, Keene KL, Andrews JS, Smith JA, Faul JD, Guangfa Z, Guo W, Liu Y, Murray SS, Musani SK, Srinivasan S, Velez Edwards DR, Wang H, Becker LC, Bovet P, Bochud M, Broeckel U, Burnier M, Carty C, Chasman DI, Ehret G, Chen WM, Chen G, Chen W, Ding J, Dreisbach AW, Evans MK, Guo X, Garcia ME, Jensen R, Keller MF, Lettre G, Lotay V, Martin LW, Moore JH, Morrison AC, Mosley TH, Ogunniyi A, Palmas W, Papanicolaou G, Penman A, Polak JF, Ridker PM, Salako B, Singleton AB, Shriner D, Taylor KD, Vasan R, Wiggins K, Williams SM, Yanek LR, Zhao W, Zonderman AB, Becker DM, Berenson G, Boerwinkle E, Bottinger E, Cushman M, Eaton C, Nyberg F, Heiss G, Hirschhron JN, Howard VJ, Karczewsk KJ, Lanktree MB, Liu K, Loos R, Margolis K, Snyder M, Psaty BM, Schork NJ, Weir DR, Rotimi CN, Sale MM, Harris T, Kardia SL, Hunt SC, Arnett D, Redline S, Cooper RS, Risch NJ, Rao DC, Rotter JI, Chakravarti A, Reiner AP, Levy D, Keating BJ, Zhu X.  (2013). American Journal of Human Genetics.

Association of adiposity genetic variants with menarche timing in 92,105 women of european descent. Fernandez-Rhodes L, Demerath EW, Cousminer DL, Tao R, Dreyfus JG, Esko T, Smith AV, Gudnason V, Harris TB, Launer L, McArdle PF, Yerges-Armstrong LM, Elks CE, Strachan DP, Kutalik Z, Vollenweider P, Feenstra B, Boyd HA, Metspalu A, Mihailov E, Broer L, Zillikens MC, Oostra B, van Duijn CM, Lunetta KL, Perry JR, Murray A, Koller DL, Lai D, Corre T, Toniolo D, Albrecht E, Stockl D, Grallert H, Gieger C, Hayward C, Polasek O, Rudan I, Wilson JF, He C, Kraft P, Hu FB, Hunter DJ, Hottenga JJ, Willemsen G, Boomsma DI, Byrne EM, Martin NG, Montgomery GW, Warrington NM, Pennell CE, Stolk L, Visser JA, Hofman A, Uitterlinden AG, Rivadeneira F, Lin P, Fisher SL, Bierut LJ, Crisponi L, Porcu E, Mangino M, Zhai G, Spector TD, Buring JE, Rose LM, Ridker PM, Poole C, Hirschhorn JN, Murabito JM, Chasman DI, Widen E, North KE, Ong KK, Franceschini N. (2013). American Journal of Epidemiology, 178(3), 451-460.

Discovery and fine mapping of serum protein loci through transethnic meta-analysis. Franceschini N, van Rooij FJ, Prins BP, Feitosa MF, Karakas M, Eckfeldt JH, Folsom AR, Kopp J, Vaez A, Andrews JS, Baumert J, Boraska V, Broer L, Hayward C, Ngwa JS, Okada Y, Polasek O, Westra HJ, Wang YA, Del Greco MF, Glazer NL, Kapur K, Kema IP, Lopez LM, Schillert A, Smith AV, Winkler CA, Zgaga L, Bandinelli S, Bergmann S, Boban M, Bochud M, Chen YD, Davies G, Dehghan A, Ding J, Doering A, Durda JP, Ferrucci L, Franco OH, Franke L, Gunjaca G, Hofman A, Hsu FC, Kolcic I, Kraja A, Kubo M, Lackner KJ, Launer L, Loehr LR, Li G, Meisinger C, Nakamura Y, Schwienbacher C, Starr JM, Takahashi A, Torlak V, Uitterlinden AG, Vitart V, Waldenberger M, Wild PS, Kirin M, Zeller T, Zemunik T, Zhang Q, Ziegler A, Blankenberg S, Boerwinkle E, Borecki IB, Campbell H, Deary IJ, Frayling TM, Gieger C, Harris TB, Hicks AA, Koenig W, CJ OD, Fox CS, Pramstaller PP, Psaty BM, Reiner AP, Rotter JI, Rudan I, Snieder H, Tanaka T, van Duijn CM, Vollenweider P, Waeber G, Wilson JF, Witteman JC, Wolffenbuttel BH, Wright AF, Wu Q, Liu Y, Jenny NS, North KE, Felix JF, Alizadeh BZ, Cupples LA, Perry JR, Morris AP.  (2012). American Journal of Human Genetics, 91(4), 744-753.

Meta-analysis of genome-wide association studies from the charge consortium identifies common variants associated with carotid intima media thickness and plaque. Bis JC, Kavousi M, Franceschini N, Isaacs A, Abecasis GR, Schminke U, Post WS, Smith AV, Cupples LA, Markus HS, Schmidt R, Huffman JE, Lehtimaki T, Baumert J, Munzel T, Heckbert SR, Dehghan A, North K, Oostra B, Bevan S, Stoegerer EM, Hayward C, Raitakari O, Meisinger C, Schillert A, Sanna S, Volzke H, Cheng YC, Thorsson B, Fox CS, Rice K, Rivadeneira F, Nambi V, Halperin E, Petrovic KE, Peltonen L, Wichmann HE, Schnabel RB, Dorr M, Parsa A, Aspelund T, Demissie S, Kathiresan S, Reilly MP, Taylor K, Uitterlinden A, Couper DJ, Sitzer M, Kahonen M, Illig T, Wild PS, Orru M, Ludemann J, Shuldiner AR, Eiriksdottir G, White CC, Rotter JI, Hofman A, Seissler J, Zeller T, Usala G, Ernst F, Launer LJ, D'Agostino RB, Sr., O'Leary DH, Ballantyne C, Thiery J, Ziegler A, Lakatta EG, Chilukoti RK, Harris TB, Wolf PA, Psaty BM, Polak JF, Li X, Rathmann W, Uda M, Boerwinkle E, Klopp N, Schmidt H, Wilson JF, Viikari J, Koenig W, Blankenberg S, Newman AB, Witteman J, Heiss G, Duijn C, Scuteri A, Homuth G, Mitchell BD, Gudnason V, O'Donnell CJ. (2011). Nature Genetics, 43(10), 940-948.

Education

MPH, Epidemiology, University of North Carolina at Chapel Hill, 2004

Clinical/Research Fellowship, Nephrology, Duke University, 2000

Residency, Internal Medicine, University of Utah, 1998

MD, Medicine, Universidade Federal do Rio Grande do Sul, 1986