Natalia I. Krupenko, PhD
About
Natalia Krupenko is an Associate Professor with more than 20 years of experience researching the role of folate vitamin in health and disease.
Natalia Krupenko in the Gillings News
- UNC nutrition experts uncover structure of enzyme that could aid in disease treatment, prevention
- Researchers identify natural molecule that binds to and enhances function of ‘tumor-suppressor’ protein
- Newly discovered regulatory link between cells could lead to novel cancer therapies
- Folate — friend or foe?
Honors and Awards
1st Place Poster Award
2012, Advances and Controversies in B-vitamins and Choline Conference, Leipzig, Germany
Key Publications
CerS6 is a Novel Transcriptional Target of p53 Activated by Non-Genotoxic Stress. Fekry B., Jeffries K.A., Esmaeilniakooshkghazi A., Ogretmen B., Krupenko S.A., Krupenko N.I. (2016). J Biol Chem, Jun 14.
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A novel tumor suppressor function of glycine N-methyltransferase is independent of its catalytic activity but requires nuclear localization. DebRoy S., Kramarenko I., Ghose S., Oleinik N.V., Krupenko S.A. and Krupenko N.I. (2013). PLOS One, 8(7).
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A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development. Christensen K.E., Deng L., Leung K.Y., Arning E., Bottiglieri T., Malysheva O.V., Caudill M.A., Krupenko N.I., Greene N.D., Jerome-Majewska L., MacKenzie R.E., Rozen R. (2013). Human Molecular Genetics, 22.
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Folate stress induces apoptosis via p53-dependent de novo ceramide synthesis and up-regulation of ceramide synthase 6. Hoeferlin L.A., Fekry B., Krupenko S., Krupenko N.I. (2013). J Biol Chem, 288(18), 12880-12890.
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Molecular mechanisms underlying the potentially adverse effects of folate. Strickland K.C., Krupenko N.I., Krupenko S.A. (2013). Clin Chem Lab Med, 51(3), 607-616.
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Education
- B.S., Biochemistry, Byelorussian State University, Minsk, USSR, 1980
- Ph.D., Bioorganic Chemistry, Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, Minsk, USSR, 1987
- The Rockefeller Foundation Fellow in Population Sciences, Center for Reproductive Biology Research, Vanderbilt University School of Medicine, 1994
