Natalia Krupenko

Natalia I. Krupenko, PhD

Associate Professor
Department of Nutrition
500 Laureate Way
Nutrition Research Institute
University of North Carolina
Kannapolis, NC, 28081


Natalia Krupenko is an Associate Professor with more than 20 years of experience researching the role of folate vitamin in health and disease. 

Natalia Krupenko in the Gillings News

Honors and Awards

1st Place Poster Award
2012, Advances and Controversies in B-vitamins and Choline Conference, Leipzig, Germany

Key Publications

CerS6 is a Novel Transcriptional Target of p53 Activated by Non-Genotoxic Stress. Fekry B., Jeffries K.A., Esmaeilniakooshkghazi A., Ogretmen B., Krupenko S.A., Krupenko N.I. (2016). J Biol Chem, Jun 14.
View publication

A novel tumor suppressor function of glycine N-methyltransferase is independent of its catalytic activity but requires nuclear localization. DebRoy S., Kramarenko I., Ghose S., Oleinik N.V., Krupenko S.A. and Krupenko N.I. (2013). PLOS One, 8(7).
View publication

A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development. Christensen K.E., Deng L., Leung K.Y., Arning E., Bottiglieri T., Malysheva O.V., Caudill M.A., Krupenko N.I., Greene N.D., Jerome-Majewska L., MacKenzie R.E., Rozen R. (2013). Human Molecular Genetics, 22.
View publication

Folate stress induces apoptosis via p53-dependent de novo ceramide synthesis and up-regulation of ceramide synthase 6. Hoeferlin L.A., Fekry B., Krupenko S., Krupenko N.I. (2013). J Biol Chem, 288(18), 12880-12890.
View publication

Molecular mechanisms underlying the potentially adverse effects of folate. Strickland K.C., Krupenko N.I., Krupenko S.A. (2013). Clin Chem Lab Med, 51(3), 607-616.
View publication


  • B.S., Biochemistry, Byelorussian State University, Minsk, USSR, 1980
  • Ph.D., Bioorganic Chemistry, Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, Minsk, USSR, 1987
  • The Rockefeller Foundation Fellow in Population Sciences, Center for Reproductive Biology Research, Vanderbilt University School of Medicine, 1994