M. Alan Brookhart, PhD

Associate Professor Department of Epidemiology

T:(919) 843-2639


2105F McGavran-Greenberg Hall

CB #7435

Chapel Hill, NC 27599


Dr. Brookhart's research focuses on the development and application of epidemiological methods for observational studies of medications using large health care databases. He is particularly interested in two related areas: 1) understanding the determinants of physician prescribing and patient adherence and 2) detecting and controlling confounding bias in comparative effectiveness studies of medications.

Representative Courses

Epidemiologic Research with Healthcare Databases

Advanced Methods in Pharmacoepidemiology

Key Publications

Risk of death in elderly users of conventional vs. atypical antipsychotic medications. Jerry Avorn, M. Brookhart, Michael Fischer, Helen Mogun, Sebastian Schneeweiss, Daniel Solomon, Philip Wang (2005). New England Journal of Medicine, 353(22), 2335-2341.

Preference-based instrumental variable methods for the estimation of treatment effects: Assessing validity and interpreting results. M. Brookhart, Sebastian Schneeweiss (2007). International Journal of Biostatistics, 3(1).

Adherence to lipid-lowering therapy and the use of preventive health services: An investigation of the healthy user effect. Jerry Avorn, M. Brookhart, Suzanne Cadarette, Colin Dormuth, Amanda Patrick, William Shrank, Daniel Solomon (2007). American Journal of Epidemiology, 166(3), 348-354.

Physician follow-up and provider continuity are associated with long-term medication adherence: A study of the dynamics of statin use. et al., Jerry Avorn, M. Brookhart, Suzanne Cadarette, Claire Canning, Colin Dormuth, Amanda Patrick, Sebastian Schneeweiss, William Shrank, Daniel Solomon, Boris Wijk (2007). Archives of Internal Medicine, 167(8), 847-852.

Comparative mortality risk of anemia management practices in incident hemodialysis patients. Jerry Avorn, Brian Bradbury, M. Brookhart, Jun Liu, Sebastian Schneeweiss, Wolfgang Winkelmayer (2010). JAMA - Journal of the American Medical Association, 303(9), 857-864.