Leena Nylander-French, PhD, CIH
Dr. Nylander-French's research and teaching program is focused on understanding the consequences of human exposure to toxic substances. Her laboratory has pioneered quantitative measurement techniques for inhalation and skin exposures as well as for biological monitoring of toxicants to estimate total body dose, which is critical to assess risk to health. They are developing sophisticated mathematical, statistical, and toxicokinetic exposure-modeling tools in an effort to standardize and improve exposure and risk assessment. Currently, they are developing both exposure assessment methodologies and in vitro skin tissue models to investigate the role of individual genetic and epigenetic alterations to variations observed in biomarker levels after exposure to xenobiotics and to understand the impact and plausibility of these alterations on development of disease. This research requires a new scientific approach to quantitatively measure exposure to toxicants, determine individual differences, including genetic and epigenetic differences, between exposed subjects, and sophisticated exposure-modeling tools.