Danyu Lin

Dennis Gillings Distinguished Professor Department of Biostatistics

T:(919) 843-5134


3101E McGavran-Greenberg Hall

CB #7420

Chapel Hill, NC 27599


Dr. Lin is the Dennis Gillings Distinguished Professor of biostatistics, a member of the Lineberger Comprehensive Cancer Center and a member of the Center for AIDS Research.

Dr. Lin has published over 170 peer-reviewed articles, most of which have appeared in leading statistical and genetic journals. He has made many fundamental contributions to statistical methods for the designs and analysis of biomedical studies, especially in the areas of survival analysis and statistical genetics. Several of his methods have been incorporated into commercial software packages and commonly used in biomedical studies. Dr. Lin has extensive applied research experience in cancer, AIDS, psychiatry and cardiovascular diseases.

Honors and Awards

Keynote address, ICSA Applied Statistics Symposium
2011, International Chinese Statistical Association (ICSA)

Merit Award
2005-2015, NIH

JRSS(B) Discussion Paper

Theory and Methods Discussion Papers
2006, JASA

Highly Cited Researcher in Mathematics
2003, Thomson ISI

Odoroff Memorial Lecturer
2003, University of Rochester

Myrto Lefkopoulou Distinguished Lecturer
2002, Harvard School of Public Health

2000, American Statistical Association

Theory and Methods Discussion Papers
2000, JASA

Mortimer Spiegelman Award
1999, American Public Health Association

1999, Institute of Mathematical Statistics

First Independent Research Award
1992-1997, National Institutes of Health

Teaching Interests

Theory and Methods of Survival Analysis (BIOS 280), 2002, 2004, 2005
Theory and Methods of Survival Analysis (BIOS 780), 2007, 2009, 2010, 2013, 2015
Statistical Methods in Genetic Association Studies (BIOS 740), 2012
Statistical Methods in Genetic Association Studies (BIOS 782), 2014, 2016

Research Activities

Statistical genetics, Genetic epidemiology, Bioinformatics, Survival analysis, Longitudinal data analysis, Designs and analysis of medical studies, Health economics

Service Activities

Associate Editor, Journal of the American Statistical Association – Applications and Case Studies, 2012-present

Associate Editor, Biometrika, 1999-present

Associate Editor, Statistica Sinica, 1999-2009

Associate Editor, Scandinavian Journal of Statistics, 2006-2009

Associate Editor, Biometrics, 1997-2000

Associate Editor, Probability and Statistics Letters, 1998-2001

Organizer/Chair for invited paper sessions of ASA, IMS and Biometric Society meetings Organizing Committee (Chair), First Seattle Symposium in

Biostatistics: Survival Analysis, 1994-95

Biostatistics Study Section, National Institutes of Health, 1997

Reviewer of grant applications for the U.S. National Science Foundation and the Natural Sciences and Engineering Research Council of Canada Program Committee, 4th ICSA Statistical Conference, 1998

IMS Program Committee, Joint Statistical Meetings, 1999

AIDS & Related Research Review Group, National Institutes of Health, 1999

Organizing Committee (Chair), Second Seattle Symposium in Biostatistics: Analysis of Correlated Data, 1999-2000

Visiting Lecturer Program in Statistical Science, Committee of Presidents of the Statistical Societies (COPSS), 2000-present

Mortimer Spiegelman Award Committee, American Public Health Association, 2000-2002 (Chair, 2002)

Social Sciences, Nursing, Epidemiology and Methods (SNEM-5) Study Section, National Institutes of Health, 2001-2003

Site Visit Team, Biostatistics Branch, National Cancer Institute, 2002

Review Panel for SNEM-5 Member Applications, National Institutes of Health, 2002

Program Committee, ENAR 2004 Spring Meetings

Review Panel for BMRD Member Applications, National Institutes of Health, 2004-2006

National Heart, Lung and Blood Institute’s Protocol Review and DSMB Committees for the Cardiovascular Outcomes in Renal Atherosclerotic Lesions Trial, 2004-present

Independent Expert Panel, U.S. Department of Health and Human Services, Health Resources and Services Administration, 2004

National Cancer Institute P01 Cluster Review, 2006th Program Committee (Chair) and Organizing Committee (Co-Chair), ICSA 16 Applied Statistics Symposium, 2006-2007

External Advisory Committee, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 2007

Tenure Review Committee, Harvard University, 2010

Staff/Administrative Duties

Biostatistics Search Committee (Chair), 2001 – 2002
Statistical Genetics Search Committee, 2001 – 2003
Graduate Studies Committee, 2001 – present
Seminar Committee, 2001 – present
BIT Committee, 2005-present
Promotion and Tenure Committee, School of Public Health, 2002 – 2006
Faculty Council, University of North Carolina, 2003 – 2008
Research Council, School of Public Health, 2006-present
Search Committee (Cancer Center Biostatistics), 2006-2007
Search Committee (Statistical Genetics), 2006-2007
Biostatistics Self-Study Committee, 2007-2008
Biostatistics Retreat Committee, 2007-2008
Junior Faculty Mentoring committees: Fei Zou (Chair), Hongtu Zhu (Chair), Amy
Herring, Anastasia Ivanova, Michael Wu, Ethan Lange (Genetics), Yun Li
(Genetics), Sun Wei (Chair) Search Committee (Clinical Trials), 2008-2009
Search Committee (Statistical Genetics), 2008-2009 Search Committee (Chair, Infectious Diseases), 2010-2011 Search Committee (Chair, Statistical Genetics), 2013-2014

Key Publications

Efficient estimation of semiparametric transformation models for two-phase cohort studies. D.Y. Lin, Donglin Zeng (2014). Journal of the American Statistical Association, 109(505), 371-383.

Loss-of-function mutations in APOC3, triglycerides, and coronary disease. Goncalo Abecasis, David Altshuler, Diego Ardissino, Rosanna Asselta, Themistocles Assimes, Paul Auer, Christie Ballantyne, Eric Boerwinkle, Erwin Bottinger, Jacy Crosby, David Crosslin, L. Cupples, Franziska Degenhardt, Panos Deloukas, Mark DePristo, Ron Do, Stefano Duga, Raimund Erbel, Jeanette Erdmann, Stefan Escher, Deborah Farlow, Martin Farrall, Caroline Fox, Nora Franceschini, Stacey Gabriel, Domenico Girelli, Anuj Goel, Omri Gottesman, Namrata Gupta, Alistair Hall, George Hindy, Oddgeir Holmen, Youna Hu, Kristian Hveem, Jan-Håkan Jansson, Gail Jarvik, Goo Jun, Hyun Kang, Stavroula Kanoni, Sekar Kathiresan, Werner Koch, Inke Konig, Charles Kooperberg, Jochen Kruppa, Leslie Lange, Wolfgang Lieb, Dan-Yu Lin, Ruth Loos, Yingchang Lu, Lisa Martin, Nicola Martinelli, Nicholas Masca, Ruth McPherson, Thomas Meitinger, Olle Melander, Pier Merlini, Deborah Nickerson, Majid Nikpay, Kari North, Christopher O'Donnell, Oliviero Olivieri, Jose Ordovas, Marju Orho-Melander, Colin Palmer, Gina Peloso, Annette Peters,  (2014). New England Journal of Medicine, 371(1), 22-31.

Meta-analysis of sequencing studies with heterogeneous genetic associations. Dan-Yu Lin, Zheng-Zheng Tang (2014). Genetic Epidemiology, 38(5), 389-401.

Survival analysis with incomplete genetic data. D.Y. Lin (2014). Lifetime Data Analysis, 20(1), 16-22.

Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. Goncalo Abecasis, David Altshuler, Themistocles Assimes, Paul Auer, Christie Ballantyne, Joshua Bis, Chris Bizon, Michael Boehnke, Eric Boerwinkle, Ingrid Borecki, Erwin Bottinger, Christopher Carlson, Y. Chen, Adolfo Correa, Jacy Crosby, David Crosslin, L. Cupples, Ron Do, Qing Duan, Cornelia Duijn, Peter Durda, Deborah Farlow, Mary Feitosa, Jason Flannick, Aaron Folsom, Myriam Fornage, Ervin Fox, Nora Franceschini, Christian Fuchsberger, Stacey Gabriel, Kyle Gaulton, Omri Gottesman, Michael Griswold, Leif Groop, Caroline Hayward, Albert Hofman, Oddgeir Holmen, Youna Hu, Jennifer Huffman, Kristian Hveem, Aaron Isaacs, Rebecca Jackson, Johanna Jakobsdottir, Gail Jarvik, Shuo Jiao, Vilmundur Jr., Goo Jun, Hyun Kang, Sekar Kathiresan, Charles Kooperberg, Ethan Lange, Leslie Lange, Daniel Levy, Yun Li, Kuo-Ping Li, Dan-Yu Lin, Cecilia Lindgren, Adam Locke, Ruth Loos, Yingchang Lu, Thomas Lumley, Alisa Manning, Lisa Martin, Mark McCarthy, Thomas Meitinger, Deborah Nickerson, Kari North, Christopher O'Donnell, Gin (2014). American Journal of Human Genetics, 94(2), 233-245.


PhD, Biostatistics, University of Michigan, Ann Arbor, 1989

MS, Biostatistics, University of Michigan, Ann Arbor, 1986