Wanda M Bodnar, PhD

 

Research Assistant Professor
Environmental Sciences and Engineering

Director, Biomarker Mass Spectrometry Facility
Center for Environmental Health and Susceptibility (CEHS)

REACH NC (Collexis) Research Profile

153 Rosenau Hall
CB# 7431
Chapel Hill, NC
27599-7431
USA
T: 919-843-0182

wanda_bodnar@unc.edu

 

Education
1993 University of Virgina, Charlottesville, VA PhD, Chemistry
1989 Middlebury College, Middlebury, VT BA, Chemistry

 

Research interests

  • Cancer
  • Cardiovascular disease
  • Diabetes
  • Environment (general)
  • Infectious diseases
  • Metabolism

 

Research activities

Research Assistant Professor Bodnar’s research activities include the development and application of analytical methods for the quantitative and qualitative analysis of surrogate markers of exposure, disease, and drug treatment. Her expertise is bioanalytical mass spectrometry and she has several years of experience using this technology to analyze both small molecules and larger biomolecules. Her laboratory, the Biomarker Mass Spectrometry Core Facility, routinely collaborates with investigators from multiple disciplines to develop assays and analyze samples of an environmental and/or biological nature. Current projects include quantitative analysis using LC-MS/MS to measure DNA and protein adducts as markers of oxidative stress, DNA damage, or chemical exposure, identification and quantitation of oxidative and phase II metabolites from in vitro and in vivo studies for use as biomarkers, accurate mass analysis for metabolomic profiling and characterization of reaction products and intermediates, and multi-elemental analysis by ICP-MS.

 
Key publications
 

Igor Koturbash, Anne Scherhag, Jessica Sorrentino, Kenneth Sexton, Wanda Bodnar, Volodymyr Tryndyak, John R. Latendresse, James A. Swenberg, Frederick A. Beland, Igor P. Pogribny, Ivan Rusyn (2010) Epigenetic Alterations in Liver of C57BL/6J Mice after Short-Term Inhalational Exposure to 1,3-Butadiene. Environmental Health Perspectives: vol.119 (5), p.635-640.

D. Slade, N. Pelz, W. Bodnar, J. Lampe, and P. Watson (2009) Indazoles: Regioselective Protection and Subsequent Amine Coupling Reactions. Journal of Organic Chemistry: vol.74, p.6331-6334.

P. Cutler, E. Akuffo, W. Bodnar, D. Briggs, J. Davis, C. Debouck, S. Fox, R. Gibson, D. Gormely, J. Holbrook, J. Hunter, E. Kinsey, R. Prinjha, J. Richardson, A. Roses, M. Smith, N. Tsokanas, D. Wille, W. Wu, J. Yates, and I. Gloger (2008) Proteomic identification and early validation of complement 1 inhibitor and pigment epithelium-derived factor: Two novel biomarkers of Alzheimer’s disease in human plasma. Proteomics-Clinical Applications: vol.2(4), p.467-477.

W. M. Bodnar, R. K. Blackburn, J. M. Krise, M. A. Moseley (2003) Exploiting the Complementary Nature of MALDI/MS/MS and LC/ESI/MS/MS for Increased Proteome Coverage. Journal of the American Society for Mass Spectrometry: vol.14(9), p.971-979.

T. G. Kingan, W. M. Bodnar, A. K. Raina, J. Shabanowitz, and D. F. Hunt (1995) The Loss of Female Sex Pheromone after Mating in the Corn Earworm Moth, Helicoverpa zea: Identification of a Male Pheromonstatic Peptide. Proc. Natl. Acad. Sci., USA: vol.92, p.5082-5086.