Rosalind Coleman, MD
Department of Nutrition
2301 Michael Hooker Res
Case Western Reserve School of Medicine
Dr. Coleman’s studies investigate lipid metabolism, particularly triacylglycerol biosynthesis and its critical regulated pathways in liver, muscle, heart, and adipocytes. She is particularly interested in understanding the controls on triacylglycerol synthesis and acyl-CoA partitioning. Using recombinant enzyme isoforms, knockout mice and cell culture models, members of her lab are identifying the regulatory controls on enzymes that commit acyl-CoAs to either beta-oxidation or to storage as complex lipids. These studies will enable us to understand and treat disorders that involve disturbed lipid metabolism, including obesity, diabetes, and heart disease. Dr. Coleman’s recently published studies of knockout mice have provided strong evidence that hepatic insulin resistance is caused by intermediates in the synthesis of triacylglycerol that impair insulin signaling. These studies directly link insulin resistance to the increased synthesis and accumulation of triacylglycerol in liver and muscle. Dr. Coleman was awarded the Osbourne and Mendel Award for her work on the synthesis and metabolism of triacylglycerol, and five of her recent doctoral students have won national awards for their research.