Environmental Sciences & Engineering
1995 William Smith College BS, Biology
1997 Tulane University MS, Biology
2000 Tulane University PhD, Biology
- Child development
- Environment (water)
- Global health
The lab focuses on understanding how environmental exposures are associated with human disease with a particular focus on genomic and epigenomic perturbations. Using environmental toxicogenomics and systems biology approaches, we aim to identify key molecular pathways that associate environmental exposure with diseases. A current focus in the lab is to study prenatal exposure to various types of metals including arsenic, cadmium, and lead. We aim to understand molecular mechanisms by which such early exposures are associated with long-term health effects in humans. For example, we are examining DNA methylation profiles in humans exposed to metals during the prenatal period. This research will enable the identification of gene and epigenetic biomarkers of metal exposure. The identified genes can serve as targets for study to unravel potential molecular bases for metal-induced disease. Ultimately, we aim to identify mechanisms of metal -induced disease and the basis for inter-individual disease susceptibility.
Smeester L, Rager JE, Bailey KA, Guan X, Smith N, García-Vargas G, Del Razo LM, Drobná Z, Kelkar H, Stíyblo M, Fry RC (2011) Epigenetic changes in individuals with arsenicosis. Chemical Research in Toxicology: vol.24(2):165-7
Benton MA, Rager JE, Smeester L, Fry RC. (2011) Comparative genomic analyses identify common molecular pathways modulated upon exposure to low doses of arsenic and cadmium. BMC Genomics: vol.12, p.2011 Apr 1;12(1):173.
Rager JE, Smeester L, Jaspers I, Sexton KG, Fry RC. (2010) Epigenetic Changes Induced by Air Toxics: Formaldehyde Exposure Alters miRNA Expression Profiles in Human Lung Cells. EHP
Liu Q, Zhang H, Smeester L, Zou F, Kesic M, Jaspers I, Pi J, Fry RC. (2010) The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel. BMC Medical Genomics: vol.3, p.37.
Fry RC, Navasumrit P, Valiathan C, Svensson JP, Hogan BJ, Luo M, Bhattacharya S, Kandjanapa K, Soontararuks S, Nookabkaew S, Mahidol C, Ruchirawat M, Samson LD (2007)
Activation of inflammation/NF-kappaB signaling in infants born to arsenic-exposed mothers. PLoS Genet.: vol.11, p.e207.