Liza Makowski, PhD


Liza Makowski 1 174Dr. Liza Makowski, PhD           Contact: 2203 McGavran Greenberg Hall 
Assistant Professor, Nutrition                                 Chapel Hill, NC 27599-7461           
Biosketch   Curriculum Vitae                                            
Research Website                                                               

The Makowski lab studies mechanisms through which metabolic reprogramming of immune cells alters the progression of diseases including obesity, atherosclerosis, and cancer. Our primary interest is to investigate how macrophage biology is influenced by fuel sources, such as glucose or fatty acids. Ultimately, linking immune cell biology and metabolism to novel pathways opens new therapeutic targets to a variety of diseases associated with inflammation and obesity. We have focused on the following themes to build such a program: 1) diet exposure and effects on inflammation; 2) manipulating fuel metabolism in immune cells; 3) examining supporting cells in the microenvironment, called the stroma, in cancer risk and progression; and 4) harnessing metabolomic technology to understand how metabolism may influence cell biology. Findings from these studies should provide targeted strategies through dietary interventions or pharmacologic therapies to translate into novel avenues of prevention and treatment. The list of chronic diseases addressed by our research includes obesity, diabetes, atherosclerosis, and obesity-driven cancers.
Active Projects
Metabolic reprogramming of macrophages and inflammation
Macrophage substrate metabolism- Obesity, inflammation and diabetes
Macrophage substrate metabolism- Atherosclerosis
Obesity, weight loss, HGF/cMET, and breast cancer
Publications:
http://www.experts.scival.com/reachnc/expertPubs.asp?n=Liza+Makowski&u_id=5000805&oe_id=1&o_id=191
Education
2003
Harvard School of Public Health, Boston, MA
PhD, Nutritional Biochemistry
1998
Harvard Medical School, Boston, MA
MSc, Medical Sciences
1994
Boston College, Chestnut Hill, MA
BS, Biology
 
For more information contact:   T: 919.843.4348 | liza.makowski@unc.edu