Leena Nylander-French, PhD
Environmental Sciences & Engineering
1986 The University of Kuopio, Finland BSc, Environmental Hygiene
1987 The University of Kuopio, Finland Chemistry
1987 The University of Kuopio, Finland MSc, Environmental Hygiene
1994 Royal Institute of Technology, Sweden PhD, Occupational & Industrial Hygiene
My research and teaching program is focused on understanding the consequences of human exposure to toxic substances. My laboratory has pioneered quantitative measurement techniques for inhalation and skin exposures as well as for biological monitoring of toxicants to estimate total body dose, which is critical to assess risk to health. We are developing sophisticated mathematical, statistical, and toxicokinetic exposure-modeling tools in an effort to standardize and improve exposure and risk assessment. Currently we are developing both exposure assessment methodologies and in vitro skin tissue models to investigate the role of individual genetic and epigenetic alterations to variations observed in biomarker levels after exposure to xenobiotics and to understand the impact and plausibility of these alterations on development of disease. This research requires a new scientific approach to quantitatively measure exposure to toxicants, determine individual differences, including genetic and epigenetic differences, between exposed subjects, and sophisticated exposure-modeling tools.
ENVR 770 Biological Monitoring in Exposure Assessment Syllabus
ENVR 430 Health Effects of Environmental Agents
- Occupational health
Kang-Sickel, J.-C.C.; Butler, M.A.; Frame, L.; Serdar, B.; Chao, Y.-C.E.; Egeghy, P.; Rappaport, S.M.; Toennis, C.A.; Li, W.; Borisova, T.; French, J.E. and Nylander-French, L.A. (2011)
The utility of naphthyl-keratin adducts as biomarkers for jet-fuel exposure.
Biomarkers: vol.16, p.590-599.
Gaines, L.G.T.; Fent, K.; Flack, S.; Thomasen, J.; Whittaker, S. and Nylander-French, L.A.: (2011)
Factors affecting variability in urinary biomarker 1,6-hexamethylene diamine in workers exposed to 1,6-hexamethylene diisocyanate (HDI).
J Environ Monit: vol.13, p.119-127.
Flack, S.; Ball, L.M. and Nylander-French, L.A. (2010)
Occupational exposure to HDI: progress and challenges in biomarker analysis.
J Chromatog B: vol.878, p.2635–2642.
Kim, D.; Andersen, M.E.; Chao, Y-C.E.; Egeghy, P.P.; Rappaport, S.M. and Nylander-French, L.A. (2007)
PBTK modeling demonstrates contribution of dermal and inhalation exposure components to end-exhaled breath concentrations of naphthalene.
Environ Health Perspect: vol.115, p.894-901.
Nylander-French, L.A. (2000)
A tape-stripping method for measuring dermal exposure to multifunctional acrylates.
Ann Occup Hyg: vol.44, p.645-651.
Chair – Conflict of Interest Committee, Gillings School of Global Public Health; Member – Research Council, Gillings School of Global Public Health; Executive Board Member – Curriculum of Toxicology, University of North Carolina at Chapel Hill