David M. Margolis, MD

 
Professor
Department of Epidemiology
Professor
School of Medicine

David M. Margolis’s website
Curriculum Vitae
David M. Margolis, Microbiology and Immunology Website
David M. Margolis, School of Medicine Website
REACH NC (Collexis) Research Profile

  120 Mason Farm Road , 2060 Genetic Medicine Bldg.
Campus Box 7042
Chapel Hill 27599-7042
USA
T: 919-966-6388


dmargo@med.unc.edu


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Education
1985 Tufts MD, Medicine
1981 Harvard College BA, Biology
 
 
Research interests

  • Clinical trials
  • Infectious diseases
  • Sexually transmitted diseases
 
Research activities

The overall goal of our laboratory is to obtain new insights into the host-virus interaction, particularly in HIV infection, and translate discoveries in molecular biology and virology to the clinic to aid in the treatment of HIV infection. A subpopulation of HIV-infected lymphocytes is able to avoid viral or immune cytolysis and return to the resting state. While this latent reservoir of HIV infection is a significant clinical problem, the molecular mechanisms that underlie it are enigmatic. Current work focuses on the molecular mechanisms that control the latent reservoir of HIV infection within resting T cells. We have found that cellular transcription factors widely distributed in lymphocytes can remodel chromatin and maintain quiescence of the HIV genome in resting CD4+ lymphocytes. Novel reagents allow us to direct modulate HIV expression in T cells obtained from HIV+ patients, and attempt to deplete the latent reservoir of HIV infection in translational clinical experiments. These studies give insight into the basic molecular mechanisms of eukaryotic gene expression, as well as new therapeutic approaches for HIV infection.