Biomarkers Mass Spectrometry sub-core

bms sub core

The Biomarker Mass Spectrometry Sub-Core provides analytical support to CEHS members and other UNC-CH researchers for qualitative and quantitative assessment of biomarkers using liquid chromatography and mass spectrometry instrumentation. The facility also collaborates with Center members to develop new assays for targeted biomarker analysis. Epidemiology and toxicology research relies in part on mass spectrometry because it is a very sensitive and specific analytical technique which generates data that enhances our understanding of molecular mechanisms of environmentally related disease processes and because it provides ultra-sensitive detection of biomarkers of environmental and endogenous exposure. Equipment available to Center members through this facility includes:

  • Agilent 7500cx Inductively Coupled Plasma Mass Spectrometer (ICP-MS) with Agilent 1260 Infinity Bioinert LC
  • AB Sciex 6500 triple quadrupole mass spectrometer with Eksigent nanoLC Ultra 2D chromatography system
  • Thermo Scientific Quantum Classic triple quadrupole mass analyzer with Thermo Accela Ultra Performance Liquid Chromatography (UPLC) separation system
  • Thermo Scientific TSQ Quantum Ultra triple quadrupole mass analyzer with Waters Acquity UPLC separation system
  • Thermo Scientific TSQ Quantum Ultra triple quadrupole mass analyzer with Waters NanoAcquity UPLC separation system
  • Agilent 1200 series [conventional] HPLC for off-line purification of biomarkers from highly complex biological samples
  • Agilent 6520 Accurate Mass Quadrupole Time-of-Flight mass spectrometer (QTOF-MS)

Sub-core director:
Wanda Bodnar, PhD; Department of Environmental Sciences and Engineering
Email: wanda_bodnar@unc.edu Phone: (919) 843- 0182

Research specialists:
Peter Cable, BS
Leonard Collins, BS, MBA