Pulmonary Disease FIRG
Leader: Dr. David Peden, Director of the UNC Center for Environmental Medicine, Asthma and Lung Biology
The Pulmonary Disease FIRG is studying genetic and environmental influences on asthma. Multidisciplinary studies combine cellular, molecular and immunologic biology with respiratory physiology, epidemiology and preclinical studies to identify susceptibility factors for increased risk of environmental asthma.
Recent work indicates that people may vary in the way that environmental air pollutants influence immune response in the lung (for instance, specific genotypes, such as GSTP-null, can modulate immune response to diesel exhaust). Access to these facilities in the UNC Center for Environmental Medicine, Asthma and Lung Biology enables CEHS investigators to extend basic science, mechanistic and other animal findings into humans. This work, in turn, enables examination of gene-environment interactions and the testing of potential interventions in focused, proof-of-concept studies.
Funded by NIEHS Grant # P30 ES010126