Elucidating and Reducing Risks from Superfund Chemicals FIRG


Leader: Dr. James Swenberg, CEHS Director, Director of UNC Superfund Research Program, and Professor of Nutrition, UNC Gillings School of Global Public Health
 
CEHS members have a long record of accomplishment in the field of carcinogenesis, and much of this work has been conducted in the context of the Elucidating and Reducing Risks from Superfund Chemicals. The Superfund Research Program or SRP (P42-ES05948) has supported Dr. Swenberg and numerous collaborators for the past fifteen years.  

UNC CEHS and SRP researchers lead the nation in identification and development of ultra-sensitive markers of carcinogen exposure and effect. These efforts rely heavily on the biomarkers sub-core of the Systems Biology Facility Core (SBFC) in CEHS. In addition, the SBFC benefits from the SRP Chemistry and Analytical Core, which provides synthesis of analyte and stable isotope internal standards and characterization of chemical structures with advanced nuclear magnetic resonance (NMR).

Dr. Ivan Rusyn’s laboratory has an active research portfolio with a focus on the mechanisms of action of environmental toxicants and the genetic determinants of susceptibility to toxicant-induced injury. These studies are improving our understanding of the mechanisms of toxicity of butadiene and our ability to assess the risks of butadiene exposure in humans.  Dr. Paul Watkins, who served as the first director of the NC TraCS Institute and now heads the Center for Drug Safety Sciences in the Hamner Research Institutes, has a strong research program to investigate the causes of adverse, hepatotoxic, reactions to xenobiotics.  

Funded by NIEHS Grant # P30 ES010126