Courses

 

Three views of courses offered by faculty in Biostatistics (BIOS):


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Official course descriptions taken from the UNC Graduate Record are below.

Additional courses may be added on a semester basis at discretion of the department. See UNC Registrar’s site for courses by semester.

Some titles link to the syllabus for that course. Please note that some syllabi are for past semesters, so dates will not apply to future semesters. The following courses require special arrangements with instructor for both all semesters offered: BIOS 740, 842,850, 992, 993 and 994.


BIOS 392 Undergraduate Internship
1‑3 Credit Hours

Academic credit for approved internship experience.

BIOS 500H Introduction to Biostatistics
3 Credit Hours | Syllabus: http://sph.unc.edu/files/2013/12/700229718_sy_BIOS500H_20139.pdf

Prerequisite, MATH 231 and 232; corequisite, BIOS 511. Access to SAS, Excel required. Permission of instructor for nonmajors. Introductory course in probability, data analysis, and statistical inference designed for BSPH biostatistics students. Topics include sampling, descriptive statistics, probability, confidence intervals, tests of hypotheses, chi-square distribution, 2-way tables, power, sample size, ANOVA, non-parametric tests, correlation, regression, survival analysis.

BIOS 511 Introduction to Statistical Computing and Data Management
Semesters Offered: Fall | 4 Credit Hours | Syllabus: http://sph.unc.edu/files/2013/12/BIOS511_20139.pdf

Required preparation, previous or concurrent course in applied statistics. Permission of instructor for nonmajors. Introduction to use of computers to process and analyze data, concepts and techniques of research data management, and use of statistical programming packages and interpretation. Focus is on use of SAS for data management and reporting.

BIOS 545 Principles of Experimental Analysis
Syllabus: http://sph.unc.edu/files/2013/12/bios545_syllabus_2014.pdf
BIOS 550 Basic Elements of Probability and Statistical Inference I
Semesters Offered: Fall | 4 Credit Hours | Syllabus: http://sph.unc.edu/files/2013/12/BIOS550_20139.pdf

Required preparation, two semesters of calculus (such as MATH 231, 232). Fundamentals of probability; discrete and continuous distributions; functions of random variables; descriptive statistics; fundamentals of statistical inference, including estimation and hypothesis testing.

BIOS 600-001f Principles of Statistical Inference
Semesters Offered: Fall | 3 Credit Hours | Syllabus: http://sph.unc.edu/files/2013/12/BIOS600_20139-2.pdf

Required preparation, knowledge of basic descriptive statistics. Major topics include elementary probability theory, probability distributions, estimation, tests of hypotheses, chi-squared procedures, regression, and correlation.

BIOS 600-971f Principles of Statistical Inference
Semesters Offered: Fall
Online only
| 3 Credit Hours | Syllabus: http://sph.unc.edu/files/2013/12/BIOS600_20139.pdf

Required preparation, knowledge of basic descriptive statistics. Major topics include elementary probability theory, probability distributions, estimation, tests of hypotheses, chi-squared procedures, regression, and correlation.

BIOS 600-002 Principles of Statistical Inference
Semesters Offered: Fall | 3 Credit Hours | Syllabus: http://sph.unc.edu/files/2013/12/BIOS600_002_2139.pdf

Required preparation, knowledge of basic descriptive statistics. Major topics include elementary probability theory, probability distributions, estimation, tests of hypotheses, chi-squared procedures, regression, and correlation.

BIOS 660 Probability and Statistical Inference I
Semesters Offered: Fall | 3 Credit Hours | Syllabus: http://sph.unc.edu/files/2013/12/Bios660_20139.pdf

Required preparation, three semesters of calculus (such as MATH 231, 232, 233). Introduction to probability; discrete and continuous random variables; expectation theory; bivariate and multivariate distribution theory; regression and correlation; linear functions of random variables; theory of sampling; introduction to estimation and hypothesis testing.

BIOS 662 Intermediate Statistical Methods
Semesters Offered: Fall | 4 Credit Hours | Syllabus: http://sph.unc.edu/files/2013/12/BIOS662_-20139.pdf

Pre- or corequisites, BIOS 511 and 550. Principles of study design, descriptive statistics, sampling from finite and infinite populations, inferences about location and scale. Both distribution-free and parametric approaches are considered. Gaussian, binomial, and Poisson models, one-way and two-way contingency tables.

BIOS 665 Analysis of Categorical Data
Semesters Offered: Fall | 3 Credit Hours | Syllabus: http://sph.unc.edu/files/2013/12/BIOS665_-2139.pdf

Prerequisites, BIOS 545, 550, and 662. Permission of the instructor for students lacking the prerequisites. Introduction to the analysis of categorized data: rates, ratios, and proportions; relative risk and odds ratio; Cochran-Mantel-Haenszel procedure; survivorship and life table methods; linear models for categorical data. Applications in demography, epidemiology, and medicine.

BIOS 667 Applied Longitudinal Data Analysis
Semesters Offered: Fall | 3 Credit Hours | Syllabus: http://sph.unc.edu/files/2013/12/BIOS667_2139.pdf

Analysis of variance and multiple linear regression course at the level of BIOS 545 or 663 required. Familiarity with matrix algebra recommended. Univariate and multivariate repeated measures ANOVA, GLM for longitudinal data, linear mixed models. Estimation and inference, maximum and restricted maximum likelihood, fixed and random effects.

BIOS 669
Semesters Offered: Spring | Syllabus: http://sph.unc.edu/files/2013/12/BIOS669_20142.pdf
BIOS 670 Demographic Techniques I
Semesters Offered: Fall | 3 Credit Hours | Syllabus: http://sph.unc.edu/files/2013/12/BIOS670_21391.pdf
This course is global.

Source and interpretation of demographic data; rates and ratios, standardization, complete and abridged life tables; estimation and projection of fertility, mortality, migration, and population composition.

BIOS 691 Field Observations in Biostatistics
Semesters Offered: Fall | 1 Credit Hour | Syllabus: http://sph.unc.edu/files/2013/12/BIOS691_20139.pdf

Field visits to, and evaluation of, major nonacademic biostatistical programs in the Research Triangle area. Field fee: $25.

BIOS 692H Honors Research in Biostatistics
3 Credit Hours

Directed research. Written and oral reports required.

BIOS 700 Research Skills in Biostatistics
1 Credit Hour

Prerequisites, BIOS 760, 761 or 758, 762, 763, and 767. Permission of the department for students with passing grade of either doctoral qualifying examination in biostatistics. BIOS 700 will introduce doctoral students in biostatistics to research skills necessary for writing a dissertation and for a career in research.

BIOS 735 Statistical Computing - Basic Principles and Applications
Semesters Offered: Fall | 3 Credit Hours | Syllabus: http://sph.unc.edu/files/2013/12/BIOS735_20139.pdf

Prerequisite, BIOS 661. Required preparation, familiarity with one computer system and either a computer language or computer package. Basic theory and application of computing as a tool in statistical research and practice. Topics include algorithms and data structures, linear and nonlinear systems, function approximation, numerical integration, the EM algorithm, simulation, and document preparation.

BIOS 740 Specialized Methods in Health Statistics
1‑21 Credit Hours

Permission of the instructor. Statistical theory applied to special problem areas of timely importance in the life sciences and public health. Lectures, seminars, and/or laboratory work, according to the nature of the special area under study.

BIOS 752 Design and Analysis of Clinical Trials
3 Credit Hours

Prerequisites, BIOS 600 and 661. This course will introduce the methods used in clinical. Topics include dose-finding trials, allocation to treatments in randomized trials, sample size calculation, interim monitoring, and non-inferiority trials.

BIOS 758 Advanced Statistical Methods in Biometric and Public Health
4 Credit Hours

Prerequisites, BIOS 660 and 661. Introduction to probability theory, statistics, stochastic processes, and martingales. Finite sample methods. Basic statistical estimator properties. Stochastic convergence and central limit theorems. Transformation of variables and variance stabilization. Neyman-Pearson hypothesis testing methodology. Large sample inference methods, likelihood ratio, Rao’s score, and Wald tests. Categorical data and regression models. Resampling plans.

BIOS 760 Advanced Probability and Statistical Inference I
Semesters Offered: Fall | 4 Credit Hours | Syllabus: http://sph.unc.edu/files/2013/12/BIOS760_2139.pdf

Prerequisite, BIOS 661. Permission of the instructor for students lacking the prerequisite. Measure space, sigma-field, measurable functions, integration, conditional probability, distribution functions, characteristic functions, convergence modes, SLLN, CLT, Cramer-Wold device, delta method, U-statistics, martingale central limit theorem, UMVUE, estimating function, MLE, Cramer-Rao lower bound, information bounds, LeCam’s lemmas, consistency, efficiency, EM algorithm.

BIOS 762 Advanced Linear Models I
Semesters Offered: Fall | 4 Credit Hours | Syllabus: http://sph.unc.edu/files/2013/12/BIOS779_20139.pdf

Prerequisites, BIOS 661 and 663, MATH 547, and 416 or 577. Theory and methods for continuous responses. Matrix theory, multivariate normal distribution, multivariate quadratic forms, estimability, reparameterization, linear restrictions and splines, estimation theory, weighted least squares, multivariate tests of linear hypotheses, multiple comparisons, confidence regions, prediction intervals, statistical power, mixed models, transformations and diagnostics, growth curve models, dose-response models, missing data.

BIOS 765 Models and Methodology in Categorical Data
3 Credit Hours

Prerequisites, BIOS 661, 663, 665, and 666. Theory of statistical methods for analyzing categorical data by means of linear models; multifactor and multiresponse situations; interpretation of interactions.

BIOS 779 Bayesian Statistics
Semesters Offered: Fall | 4 Credit Hours | Syllabus: http://sph.unc.edu/files/2013/12/BIOS779_20139.pdf

Prerequisite, BIOS 762. Bayes’ theorem, likelihood principle, prior distributions, posterior distributions, and predictive distributions. Bayesian analysis of linear models, generalized linear models, random effects models, spatial models, and survival models. Informative prior elicitation, model comparisons, Bayesian diagnostic methods, and variable subset selection. Markov Chain Monte Carlo computations methods. Clinical trials design and analysis.

BIOS 780 Theory and Methods for Survival Analysis
Semesters Offered: Fall | 3 Credit Hours | Syllabus: http://sph.unc.edu/files/2013/12/BIOS780_20139.pdf

Prerequisites, BIOS 760 and 761. Permission of the instructor for students lacking the prerequisites. Counting process-martingale theory, Kaplan-Meier estimator, weighted log-rank statistics, Cox proportional hazards model, nonproportional hazards models, multivariate failure time data.

BIOS 781 Statistical Methods in Human Genetics
4 Credit Hours

Prerequisites, BIOS 661 and 663. Permission of the instructor for students lacking the prerequisites. An introduction to statistical procedures in human genetics, Hardy-Weinberg equilibrium, linkage analysis (including use of genetic software packages), linkage disequilibrium and allelic association.

BIOS 785 Analysis of Microarray Data
3 Credit Hours

Prerequisites, BIOS 661 and 663. Permission of the instructor for students lacking the prerequisites. Clustering algorithms, classification techniques, statistical techniques for analyzing multivariate data, analysis of high dimensional data, parametric and semiparametric models for DNA microarray data, measurement error models, Bayesian methods, statistical software, sample size determination in microarray studies, applications to cancer.

BIOS 842 Practice in Statistical Consulting
1‑21 Credit Hours

Prerequisites, BIOS 511, 545, 550, and 841. Permission of the instructor. Under supervision of a faculty member, the student interacts with research workers in the health sciences, learning to abstract the statistical aspects of substantive problems, to provide appropriate technical assistance, and to communicate statistical results.

BIOS 843 Seminar in Biostatistics
Semesters Offered: Fall, Spring | 1 Credit Hour | Syllabus: http://sph-dev.sites.unc.edu/files/2014/02/BIOS843-20142.pdf

This seminar course is intended to give students exposure ot cutting edge research topics and hopefully help them in their choice of a thesis topic. It also allows the student to meet and learn from major researchers in the field.

BIOS 844 Leadership in Biostatistics
3 Credit Hours | Syllabus: http://sph.unc.edu/files/2013/12/BIOS844_20139.pdf

Prerequisite, BIOS 841. Using lectures and group exercises, students are taught where and how biostatisticians can offer leadership in both academic and nonacademic public health settings.

BIOS 850 Training in Statistical Teaching in the Health Sciences
1‑21 Credit Hours

Required preparation, a minimum of one year of graduate work in statistics. Principles of statistical pedagogy. Students assist with teaching elementary statistics to students in the health sciences. Students work under the supervision of the faculty, with whom they have regular discussions of methods, content, and evaluation of performance.

BIOS 990 Research in Biostatistics
1‑21 Credit Hours

Individual arrangements may be made by the advanced student to spend part or all of his or her time in supervised investigation of selected problems in statistics.

BIOS 992 Master's Paper
3‑6 Credit Hours
BIOS 994 Doctoral Dissertation
3‑9 Credit Hours