1. Identify whether obesity interacts with post-pregnancy changes in microenvironment to promote carcinogenesis using mouse models of basal-like breast cancer.
2. Identify changes induced by cell-cell communication between obese microenvironment and basal-like breast cancer using co-cultures.
3. Evaluate whether the phenotypic and gene expression markers induced by parity and obesity in experimental systems are also altered in the microenvironment of basal-like breast tumors in patients.
Funded by NIEHS Grant # U01 ES019472-01