Sonia Davis, DrPH

Professor of the Practice Department of Biostatistics

T:(919) 966-8333

Sonia.Davis@unc.edu

137 East Franklin Street, Suite 203

CB #8030

Chapel Hill, NC 27599

USA

Dr. Davis is the data coordinating center principal investigator for two clinical trials: Predicting Response to Standard Pediatric Colitis Therapy (PROTECT), and Medical Optimization and Management of Pregnancies with Overt Type II Diabetes (MOMPOD).

Dr. Davis is currently the principal investigator of the Predicting Response to Standard Pediatric Colitis Therapy (PROTECT) study, and co-investigator on a number of studies, including the neurocognition components of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) and Atherosclerosis Risk in Communities (ARIC) study. She leads the Data and Safety Monitoring Board (DSMB) Independent Data Analysis Center for a phase II/III pharmaceutical program. Sonia is also an associate director in the Biostatistics Core of the North Carolina Translational & Clinical Sciences Institute (NC TraCS), UNC-Chapel Hill's Clinical and Translational Science Award (CTSA).

Dr. Davis maintains a strong academic presence as an active publishing author with more than 70 papers and two book chapters, as well as teaching the UNC Gillings graduate-level "Leadership in Biostatistics" class (BIOS 844), and guest lecturing within and outside of the school. She happily serves the students of the Department of Biostatistics as mentor and master's thesis advisor.

Honors and Awards

Inducted
1990, Delta Omega Public Health Honor Society

Representative Courses

Leadership in Biostatistics (BIOS 844)

Teaching Interests
Guest lecturer in BIOS 752 (Design and Analysis of Clinical Trials), BIOS 841 (Principals of Statistical Consulting) and EPID 733 (Clinical Trials in Epidemiology) at the Gillings School, and in DPET 833 (Experimental Design in Clinical Research) at the UNC Eshelman School of Pharmacy. Topics include:
•    Equivalence and non-inferiority
•    Missing data in clinical trials
•    DMCs/interim analysis

Research Activities

Research interests
Clinical Trials
Evidence-based public health

Research activities
Design of Phase III and Phase IV clinical trials
DSMBs
Analysis methods for clinical trials with missing data
Equivalence and non-inferiority
Multiple comparison strategies
Futility analysis

Service Activities

DSMB member for several ongoing clinical trials
American Statistical Association Biopharmaceutical Section Regulatory-Industry Workshop Steering Committee

Key Publications

Pulmonary Disease and Age at Immigration among Hispanics: Results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Barr RG, Avilés-Santa L, Davis SM, Aldrich T, Gonzalez F, Henderson AG, Kaplan RC, LaVange L, Liu K, Loredo JS, Mendes ES, Ni A, Ries A, Salathe M, Smith LJ (2016). American Journal of Respiratory and Critical Care Medicine, 193(4), 386-395.

Clinical Trials with Missing Data: a Guide for Practitioners: Chapter 5: Mixed models for repeated measures with categorical time effects (MMRM). Davis SM, O’Kelly, M and Ratitch B (2014). Wiley.

Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. Lieberman JA, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, Keefe RSE, Davis SM, Davis CE, Lebowitz BD, Severe J, Hsiao JK (2005). New England Journal of Medicine, 353(12), 1209-1223.

Education

DrPH, Biostatistics, University of North Carolina at Chapel Hill, 1994

MS, Biostatistics, University of North Carolina at Chapel Hill, 1990

BSPH, Biostatistics, University of North Carolina at Chapel Hill, 1988