David DeMarini

Adjunct Professor Environment Sciences and Engineering

Genetic Toxicologist, Integrated Systems Toxicology Division, U.S. Environmental Protection Agency (US EPA), Research Triangle Park (RTP), NC

Bio:
David M. DeMarini received the B.S. (1972), M.S. (1974), and Ph.D. (1980) in Biological Sciences (genetics) at Illinois State University, Normal, IL, studying under Dr. Herman E. Brockman.  From 1980-1982, he did postdoctoral research at the Biology Division, Oak Ridge National Laboratory, Oak Ridge, TN.  He then was a Research Geneticist at the National Toxicology Program, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC from 1983-1984. 

DeMarini began his current position as a Genetic Toxicologist at the US Environmental Protection Agency (US EPA), Research Triangle Park, NC in 1985.  He is also an Adjunct Professor, Dept. of Environ. Sci. & Engineering, School of Public Health, University of North Carolina, Chapel Hill, NC (1991-present). 

He is a member of the Environmental Mutagenesis and Genomics Society (EMGS) and the Genetics and Environmental Mutagenesis Society (GEMS).  He has served as President of EMGS, GEMS, and of the International Association of Environmental Mutagenesis and Genomics Societies.  He is an Editor of Mutation Research--Reviews (1998-present) and is on the Editorial Board of Environmental and Molecular Mutagenesis (1984-1989, 1993-present) and Genes and Environment (2006-present).  He has organized conferences, symposia, and training courses internationally, and has given invited lectures at more than 140 conferences in 55 countries.  He has served on both (1986 and 2004) Tobacco Smoking and Cancer Monographs of the International Association for Research on Cancer (IARC) with WHO in Lyon, France, as well as the IARC Monographs on Drinking Water/Arsenic, Indoor Air, Vol. 100 Human Carcinogens, Auto and Diesel Exhaust, and Outdoor Air.  He Chaired the IARC Monograph on Drinking Water, Food, and Industrial Chemicals (2011).  He has published >170 articles, 24 book chapters, and received the Alexander Hollaender Award from the EMGS in 2011.  He has mentored 10 graduate students and 10 postdocs through his adjunct professorship at UNC-Chapel Hill.  His research interests are molecular mechanisms of mutagenesis, mutation spectra, complex mixtures, and biomarkers of mutation in humans.


Honors and Awards

Lifetime Achievement Award
2015, Environmental Mutagenesis Society

Alexander Hollaender Award
2011, Environmental Mutagenesis and Genomics Society

Education Award for Dedication to Students and Young Investigators
2002, Environmental Mutagenesis and Genomics Society

Alumni Achievement Award and Alumni Hall of Fame
2000 and 2006, Illinois State University

2 Honorary Mention, 3 Level II, 3 Level III, and 1 Level I Science Technology Achievement Awards
1994, 1997, 2003, 2004, 2005, 2006, 2008, 2011, US Environmental Protection Agency (US EPA)

Representative Courses

TOXC/ENVR 442, Biochemical and Molecular Toxicology - Lecture on "Mutagenesis"

Research Activities

•    Genetic toxicology; environmental mutagenesis
•    Complex mixtures (air, water, soil); human biomarkers
•    Molecular mechanisms of mutagenesis

Key Publications

Progressive increase in disinfection byproducts and mutagenicity from source to tap to swimming pool and spa water: Impact of human inputs. EJ Daiber, DM DeMarini, SA Ravuri, HK Liberatore, AA Cuthbertson, A Thompson-Klemish, JD Byer, JE Schmid, MZ Afifi, ER Blatchley III, SD Richardson (2016). Environ Sci Technol, 50(-), 6652-6662.

Mutagenicity and pollutant emission factors of solid-fuel cookstoves: comparison to other combustion sources. E Mutlu, SH Warren, SM Ebersviller, IM Kooter, JE Schmid, JA Dye, WP Linak, MI Gilmour, JJ Jetter, M Higuchi, DM DeMarini  (2016). Environ Health Perspect, 124(-), 974-982.

Genotoxicity biomarkers of exposure to traffic and near-road atmospheres: a review. DM DeMarini  (2013). Mutagenesis, 28(-), 485-505.

Declaring the existence of human germ-cell mutagens. DM DeMarini  (2012). Environ Mol Mutagen, 53(-), 166-172.

Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research. SD Richardson, MJ Plewa, ED Wagner, R Schoeny, DM DeMarini  (2007). Mutat Res, 636(-), 178-242.

Education

PhD, Biological Sciences, Illinois State University, 1980

MS, Biological Sciences, Illinois State University, 1974

BS, Biological Sciences, Illinois State University, 1972