Brian Wells Pence, PhD

Associate Professor Department of Epidemiology

T:(919) 966-7446

bpence@unc.edu

2103C McGavran-Greenberg Hall

CB #7435

Chapel Hill, NC 27599

USA

Dr. Pence’s research focuses on the links between mental health and HIV-related behaviors and health outcomes in the Southeastern US and in Africa. He is PI or co-PI on three current or recent NIH grants, including a randomized clinical trial to assess whether depression treatment integrated into HIV clinical care in the US improves HIV medication adherence; a study to define the epidemiology of depression among HIV patients in Cameroon and pilot-test a nurse-delivered depression treatment intervention; and a study to define the impact of antidepressant treatment on HIV outcomes among HIV patients in the CNICS network of 8 large clinical sites across the US.

With Kathryn Whetten, he recently co-authored the second edition of You’re the First One I’ve Told: The Faces of HIV in the Deep South (Rutgers University Press, 2013). This book presents the life histories of 25 individuals infected with HIV and living in the US Deep South, and highlights in particular the high prevalence and profound influence of traumatic life experiences. In the second edition, the original qualitative findings are substantiated with new quantitative research, primarily drawn from the Coping with HIV/AIDS in the Southeast (CHASE) longitudinal cohort study of over 600 HIV-infected individuals from across the Southeastern US.

Representative Courses

EPID 718, Analytical Methods in Observational Epidemiology, beginning fall 2014

Key Publications

Factors associated with change in sexual transmission risk behavior over 3 years among HIV-infected patients in Tanzania. Dafrosa Itemba, Venance Maro, Brian Pence, Kristen Shirey, Nathan Thielman, Rachel Whetten, Kathryn Whetten, Jia Yao (2013). PLoS ONE, 8(12).

Trauma History and Depression Predict Incomplete Adherence to Antiretroviral Therapies in a Low Income Country. Julie Adams, Bernard Agala, Kyle Hamilton, Amy Hobbie, Dafrosa Itemba, Beatrice Lema, Yombya Madukwa, Venance Maro, Amiri Mrema, Restituta Mvungi, Karen O'Donnell, Jan Ostermann, Brian Pence, Elizabeth Reddy, Wendy Ricky, Ludovic Samora, Kristen Shirey, Nathan Thielman, Rachel Whetten, Kathryn Whetten, Jia Yao, Blandina Zenze (2013). PLoS ONE, 8(10).

Postpartum depression and HIV infection among women in Malawi. Anna Dow, Queen Dube, Brian Pence, Annelies Rie (2014). Journal of Acquired Immune Deficiency Syndromes, 65(3), 359-365.

Providers' attitudes towards treating depression and self-reported depression treatment practices in HIV outpatient care. Julie Adams, Kiana Bess, Bradley Gaynes, Amy Heine, Julie O'donnell, Brian Pence, James Raper, Nathan Thielman, Melissa Watt, Anne Zinski (2013). AIDS Patient Care and STDs, 27(3), 171-180.

Treating depression within the HIV medical home: A guided algorithm for antidepressant management by HIV clinicians. Julie Adams, Bradley Gaynes, Teena McGuinness, Riddhi Modi, Brian Pence, James Willig (2012). AIDS Patient Care and STDs, 26(11), 647-654.

Validity of an interviewer-administered patient health questionnaire-9 to screen for depression in HIV-infected patients in Cameroon. Julius Atashili, Bradley Gaynes, Dmitry Kats, Peter Ndumbe, Alfred Njamnshi, Julie O'Donnell, Brian Pence, Gladys Tayong, Kathryn Whetten, Rachel Whetten (2012). Journal of Affective Disorders, 143(1), 208-213.

Assessing the effect of Measurement-Based Care depression treatment on HIV medication adherence and health outcomes: Rationale and design of the SLAM DUNC Study. Julie Adams, Bradley Gaynes, Amy Heine, Riddhi Modi, Michael Mugavero, Brian Pence, E. Quinlivan, Nathan Thielman, Quinn Williams (2012). Contemporary Clinical Trials, 33(4), 828-838.

Prevalence of psychological trauma and association with current health and functioning in a sample of HIV-infected and HIV-uninfected Tanzanian adults. Julie Adams, Bernard Agala, Dafrosa Itemba, Brian Pence, John Shao, Kristen Shirey, Rachel Whetten, Kathryn Whetten, Jia Yao (2012). PLoS ONE, 7(5).

Falling through the cracks: the gaps between depression prevalence, diagnosis, treatment, and response in HIV care. Bradley Gaynes, Julie O'Donnell, Brian Pence (2012). AIDS (London, England), 26(5), 656-658.

Childhood trauma and health outcomes in HIV-infected patients: An exploration of causal pathways. Tandrea Carter, Jane Leserman, Michael Mugavero, Brian Pence, Rae Proeschold-Bell, James Raper, Susan Reif, Nathan Thielman, Kathryn Whetten (2011). JAIDS Journal of Acquired Immune Deficiency Syndromes.

A comparison of the wellbeing of orphans and abandoned children ages 6-12 in institutional and community-based care settings in 5 less wealthy nations. Lynne Messer, Karen O'Donnell, Jan Ostermann, Brian Pence, Nathan Thielman, Rachel Whetten, Kathryn Whetten (2009). PLoS ONE, 4(12).

Prevalence Estimation and Validation of New Instruments in Psychiatric Research: An Application of Latent Class Analysis and Sensitivity Analysis. Bradley Gaynes, William Miller, Brian Pence (2009). Psychological Assessment, 21(2), 235-239.

The impact of mental health and traumatic life experiences on antiretroviral treatment outcomes for people living with HIV/AIDS. Brian Pence (2009). Journal of Antimicrobial Chemotherapy, 63(4), 636-640.

Relation of lifetime trauma and depressive symptoms to mortality in HIV. Jane Leserman, Michael Mugavero, Brian Pence, Dalene Stangl, Marvin Swartz, Nathan Thielman, Kathryn Whetten (2007). American Journal of Psychiatry, 164(11), 1707-1713.

Psychiatric illness and virologic response in patients initiating highly active antiretroviral therapy. Bradley Gaynes, Joseph Jr., William Miller, Brian Pence (2007). Journal of Acquired Immune Deficiency Syndromes, 44(2), 159-166.

Prevalence of DSM-IV-defined mood, anxiety, and substance use disorders in an HIV clinic in the southeastern United States. Joseph Eron, Bradley Gaynes, William Miller, Brian Pence, Kathryn Whetten (2006). Journal of Acquired Immune Deficiency Syndromes, 42(3), 298-306.

Validation of a brief screening instrument for substance abuse and mental illness in HIV-positive patients. Bradley Gaynes, Joseph Jr., William Miller, Brian Pence, Robert Ryder, Kathryn Whetten (2005). Journal of Acquired Immune Deficiency Syndromes, 40(4), 434-444.

Education

PhD, Epidemiology, University of North Carolina at Chapel Hill, 2005

MPH, Epidemiology, Columbia University, 2000

BA, Economics, Yale University, 1996