Avram Gold, PhD

About

 

Honors and Awards

Fogarty International Fellowship
1986-1987, Université Louis Pasteur, Strasbourg, FR

Research Activities

The Gold laboratory research covers three areas:

-As the synthesis section of the Chemistry and Analytical Core of the Superfund Grant, the laboratory synthesizes natural abundance analytical standards and internal standards labeled with stable isotopes for analyte quantitation by isotope dilution mass spectrometry. We also perform structural analysis, specializing in heteronuclear, multidimensional NMR.

-The Superfund work has led to an interest in characterizing oxidative DNA lesions. The lab was first to characterize 2-iminohydantion, a potentially common, mutagenic lesion.

-The laboratory is working in collaboration with Jason Surratt’s atmospheric chemistry group in probing the mechanisms of formation of secondary organic aerosols. Our role is synthesis of standards, structural determinations and elucidation of photochemical oxidation pathways. This work has established importance of organic epoxides as reactive intermediates.

Key Publications

Ethenoguanines undergo glycosylation by nucleoside 2´-deoxyribosyltransferases at non-natural sites. Wenjie Ye, Debamita Paul, Lina Gao, Jolita Seckute, Ramiah Sangaiah, Karupiah Jayaraj, Zhenfa Zhang, P. Alexandre Kaminski, Steven E. Ealick, Avram Gold, Louise M. Ball (2014). PLOS ONE online.

Light-absorbing oligomer formation in secondary organic aerosol from reactive uptake of isoprene epoxydiols. Lin, Ying-Hsuan; Budisulistiorini, Sri; Chu, Kevin; Siejack, Richard; Zhang, Haofei; Riva, Matthieu; Zhang, Zhenfa; Gold, Avram; Kautzman, Kathryn; Surratt, Jason (2014). Environ. Sci. Technol., 48(.), 12012-12021.

Epoxide as a Precursor to Secondary Organic Aerosol Formation from Isoprene Photooxidation in the Presence of Nitrogen Oxides. Ying-Hsuan Lin, Haofei Zhanga, Havala O. T. Pye, Zhenfa Zhang, Wendy J. Marth, Sarah Park, Maiko Arashiro, Tianqu Cui, Sri Hapsari Budisulistiorini, Kenneth G. Sexton, William Vizuete, Ying Xie, Deborah J. Luecken, Ivan R. Piletic,Edward O. Edney, Libero J. Bartolotti, Avram Gold, Jason D. Surratt (2013). Proc. Natl. Acad. Sci. USA, 110(.), 6718-6723.

Synthesis of Uniformly 13C-Labeled Polycyclic Aromatic Hydrocarbons. Z. Zhang, R. Sangaiah, A Gold, L. M. Ball (2011). Org. Biomol. Chem., 9(.), 5431-5435.

An Iminohydantoin Lesion Induced in DNA by Peracids and Other Epoxidizing Oxidants. WenjieYe, R. Sangaiah, Diana E. Degen, Avram Gold*, K. Jayaraj, Karl M. Koshlap, Gunnar Boysen, Jason Williams, Kenneth B. Tomer, Viorel Mocanu, Nedyalka Dicheva, Carol E. Parker, Roel M. Schaaper and Louise M. Ball (2009). J. Am. Chem. Soc., 131(.), 6114-6123.

Education